SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALX_A_DVAA6_0
(GRAMICIDIN A)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 4 ALA A 126
VAL A 243
TRP A 109
TRP A  42
 None
 1.34A 1alxA-5nfqA:
undetectable
1alxB-5nfqA:
undetectable		 1alxA-5nfqA:
3.64
1alxB-5nfqA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		5 / 11 LEU A 260
VAL A 243
ILE A 125
LEU A 234
LEU A 113
 None
None
None
EDO  A 410 ( 4.9A)
EDO  A 410 ( 4.3A)
 1.07A 1mrqA-5nfqA:
undetectable		 1mrqA-5nfqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 5 ILE A 214
ARG A 155
LEU A 138
PRO A 217
 PGE  A 412 (-4.6A)
None
None
None
 1.46A 1s8fA-5nfqA:
2.9
1s8fB-5nfqA:
2.8		 1s8fA-5nfqA:
undetectable
1s8fB-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		3 / 3 PHE A 203
ARG A  64
ASN A 198
 None
 0.87A 1xzxX-5nfqA:
undetectable		 1xzxX-5nfqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 7 ALA A  88
ASP A  89
GLY A  82
ILE A  81
 None
PEG  A 402 (-3.8A)
PGE  A 413 (-3.4A)
None
 0.92A 2fxdB-5nfqA:
undetectable		 2fxdB-5nfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		3 / 3 ASP A  83
ASP A  89
ASP A  78
 None
PEG  A 402 (-3.8A)
None
 0.76A 2igtA-5nfqA:
2.1		 2igtA-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 5 ALA A 132
ALA A 112
ALA A 123
VAL A 243
 None
 0.94A 2nyrB-5nfqA:
undetectable		 2nyrB-5nfqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 7 TYR A 209
ASP A 179
ALA A 251
TYR A 150
 None
 0.88A 3rodD-5nfqA:
undetectable		 3rodD-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 6 SER A  50
ASP A  51
ARG A  52
GLU A 292
 None
 1.24A 4eysA-5nfqA:
undetectable		 4eysA-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		6 / 12 ASP A 102
PHE A 154
LEU A 172
TYR A 209
LEU A 252
HIS A 277
 PGE  A 412 ( 4.5A)
None
None
None
None
None
 1.24A 4j03A-5nfqA:
30.3		 4j03A-5nfqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		6 / 12 ASP A 102
TYR A 150
PHE A 154
TYR A 209
LEU A 252
HIS A 277
 PGE  A 412 ( 4.5A)
None
None
None
None
None
 0.49A 4j03A-5nfqA:
30.3		 4j03A-5nfqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 7 VAL A 243
ILE A 125
LEU A 234
LEU A 113
 None
None
EDO  A 410 ( 4.9A)
EDO  A 410 ( 4.3A)
 0.79A 4l1wA-5nfqA:
undetectable		 4l1wA-5nfqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		5 / 12 LEU A 237
PRO A 266
ILE A  98
LEU A 242
GLY A 100
 None
 1.26A 4l9qA-5nfqA:
undetectable		 4l9qA-5nfqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		5 / 12 LEU A 237
PRO A 266
ILE A  98
LEU A 242
GLY A 100
 None
 1.20A 4l9qB-5nfqA:
undetectable		 4l9qB-5nfqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 6 THR A  97
GLU A 121
THR A 268
LEU A 295
 None
 1.15A 4pgfA-5nfqA:
4.7		 4pgfA-5nfqA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		5 / 12 LEU A 260
VAL A 243
ILE A 125
LEU A 234
LEU A 113
 None
None
None
EDO  A 410 ( 4.9A)
EDO  A 410 ( 4.3A)
 0.96A 4yvpB-5nfqA:
undetectable		 4yvpB-5nfqA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 7 GLN A  60
GLY A 104
ILE A  98
TRP A  42
 None
 1.10A 5vlmC-5nfqA:
undetectable		 5vlmC-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 5 GLN A  60
ASP A  59
SER A  38
ARG A  64
 None
 1.29A 5w4zA-5nfqA:
undetectable		 5w4zA-5nfqA:
25.00