SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 VAL A 190
GLY A 189
ASN A 167
VAL A 161
PHE A 195
 None
 1.49A 1a27A-5nfrA:
10.4		 1a27A-5nfrA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 TYR A 294
GLY A 172
GLY A 144
THR A 252
ILE A 298
 None
 1.21A 2akeA-5nfrA:
undetectable		 2akeA-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 TYR A 294
GLY A 172
GLY A 144
THR A 252
ILE A 298
 None
 1.19A 2azxA-5nfrA:
undetectable		 2azxA-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 TYR A 294
GLY A 172
GLY A 144
THR A 252
ILE A 298
 None
 1.22A 2azxB-5nfrA:
undetectable		 2azxB-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 TYR A 294
GLY A 172
GLY A 144
THR A 252
ILE A 298
 None
 1.22A 2dr2A-5nfrA:
undetectable		 2dr2A-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 THR A 185
PRO A 180
TYR A 151
 None
 0.97A 2dxrA-5nfrA:
undetectable		 2dxrA-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 9 ILE A  73
ALA A 102
VAL A 105
CYH A 109
 None
 1.03A 2vufB-5nfrA:
undetectable		 2vufB-5nfrA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 CYH A 140
THR A 252
ILE A 274
ALA A 279
ILE A 139
 None
 1.16A 3ddyA-5nfrA:
undetectable		 3ddyA-5nfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 PHE A 251
THR A 148
ALA A 234
ILE A 236
LEU A  19
 None
 1.36A 3lcvB-5nfrA:
2.9		 3lcvB-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ASP A 122
GLY A 173
GLY A 175
GLY A 144
ASP A 147
 None
 0.90A 3uboA-5nfrA:
5.9		 3uboA-5nfrA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 GLY A  78
GLY A  10
ILE A  12
LEU A   6
 None
 0.78A 4mwzB-5nfrA:
undetectable		 4mwzB-5nfrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5nfr MALATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 8 PHE A 230
THR A  76
GLN A  11
ILE A  15
GLY A  13
 None
 1.32A 5nzxA-5nfrA:
undetectable		 5nzxA-5nfrA:
15.16