SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 6 LEU A 591
LEU A 381
LEU A 511
LEU A 435
 None
 0.86A 1errA-5nfuA:
undetectable		 1errA-5nfuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 7 ILE A 532
LEU A 541
MET A 377
LEU A 381
 None
 1.02A 2dyrN-5nfuA:
undetectable
2dyrW-5nfuA:
undetectable		 2dyrN-5nfuA:
undetectable
2dyrW-5nfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 6 ILE A 532
ARG A 579
PRO A 389
SER A 387
 None
 1.13A 2qd3B-5nfuA:
undetectable		 2qd3B-5nfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 5 ILE A 542
TYR A 552
ILE A 532
HIS A 524
 None
 1.07A 3eteB-5nfuA:
undetectable
3eteC-5nfuA:
undetectable		 3eteB-5nfuA:
10.32
3eteC-5nfuA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_D_HCZD800_1
(GLUTAMATE RECEPTOR 2)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 9 ILE A 476
PRO A 469
SER A 466
SER A 450
LEU A 442
 None
 1.22A 3ijxB-5nfuA:
0.0
3ijxD-5nfuA:
undetectable		 3ijxB-5nfuA:
14.40
3ijxD-5nfuA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ILE A 532
ILE A 521
ALA A 520
THR A 517
LEU A 590
 None
 1.24A 3s79A-5nfuA:
undetectable		 3s79A-5nfuA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 10 SER A 387
ARG A 581
ALA A 577
LEU A 580
ALA A 493
 None
 1.21A 4fe1A-5nfuA:
undetectable
4fe1J-5nfuA:
undetectable		 4fe1A-5nfuA:
8.89
4fe1J-5nfuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 10 ILE A 532
ILE A 521
ALA A 520
THR A 517
LEU A 590
 None
 1.18A 4kq8A-5nfuA:
undetectable		 4kq8A-5nfuA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 7 SER A 387
ARG A 581
ALA A 577
LEU A 580
 None
 0.63A 4xk8A-5nfuA:
undetectable		 4xk8A-5nfuA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ILE A 532
ILE A 521
ALA A 520
THR A 517
LEU A 590
 None
 1.23A 5jkvA-5nfuA:
undetectable		 5jkvA-5nfuA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 7 ILE A 532
LEU A 541
MET A 377
LEU A 381
 None
 0.82A 5xdqA-5nfuA:
undetectable
5xdqJ-5nfuA:
undetectable		 5xdqA-5nfuA:
undetectable
5xdqJ-5nfuA:
undetectable