SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ng5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 6 LEU E 348
ALA E 305
LEU E 307
THR E  47
 None
 1.20A 1tyrA-5ng5E:
undetectable		 1tyrA-5ng5E:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 6 LEU E 246
GLN E 207
ILE E 212
PHE E 280
 None
 0.93A 2jn3A-5ng5E:
undetectable		 2jn3A-5ng5E:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 LYS E 175
ARG E  69
VAL E  68
 None
 1.11A 2r2vC-5ng5E:
undetectable
2r2vD-5ng5E:
undetectable		 2r2vC-5ng5E:
7.49
2r2vD-5ng5E:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 6 ASP E 222
LEU E 226
LEU E  56
THR E  54
 None
 1.06A 3rozA-5ng5E:
undetectable		 3rozA-5ng5E:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 6 LEU E 348
ALA E 305
LEU E 307
THR E  47
 None
 1.19A 4d7bB-5ng5E:
undetectable		 4d7bB-5ng5E:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 GLN E 341
THR E  53
THR E  54
 None
 0.60A 4fu9A-5ng5E:
undetectable		 4fu9A-5ng5E:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 GLN E 341
THR E  53
THR E  54
 None
 0.61A 4fufA-5ng5E:
undetectable		 4fufA-5ng5E:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 8 ILE E 361
LEU E 353
ILE E 306
LEU E 364
 None
 0.92A 5ieoA-5ng5E:
undetectable		 5ieoA-5ng5E:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.65A 5qgzA-5ng5E:
undetectable		 5qgzA-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.67A 5qh0A-5ng5E:
undetectable		 5qh0A-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.66A 5qh2A-5ng5E:
undetectable		 5qh2A-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.67A 5qh3A-5ng5E:
undetectable		 5qh3A-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.66A 5qh6A-5ng5E:
undetectable		 5qh6A-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.65A 5qhaA-5ng5E:
undetectable		 5qhaA-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		3 / 3 VAL E 326
VAL E 332
GLN E 372
 None
 0.67A 5qhhA-5ng5E:
undetectable		 5qhhA-5ng5E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA
(Escherichia
coli) 		4 / 4 LYS E 346
LEU E 307
ALA E 342
LEU E 348
 None
 1.28A 6gnrB-5ng5E:
undetectable		 6gnrB-5ng5E:
18.24