SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ng7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 7 GLY A 104
SER A 107
TRP A  41
ALA A  56
 None
 0.82A 1gxsA-5ng7A:
8.4
1gxsB-5ng7A:
undetectable		 1gxsA-5ng7A:
undetectable
1gxsB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 7 PRO A 127
ASP A 241
HIS A 270
ALA A 243
 None
 0.89A 1gxsA-5ng7A:
8.4
1gxsB-5ng7A:
undetectable		 1gxsA-5ng7A:
undetectable
1gxsB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 5 VAL A  98
GLY A  99
VAL A 122
TRP A 237
 None
 0.97A 1tkqB-5ng7A:
undetectable		 1tkqB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 10 TYR A 148
ALA A 243
ILE A 244
VAL A 149
MET A 133
 None
 1.19A 1xp0A-5ng7A:
undetectable		 1xp0A-5ng7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 6 LEU A 170
ARG A 190
THR A 185
LEU A 184
 None
 1.08A 2dysA-5ng7A:
undetectable
2dysJ-5ng7A:
undetectable		 2dysA-5ng7A:
undetectable
2dysJ-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 12 TYR A 148
ALA A 243
ILE A 244
VAL A 149
MET A 133
 None
 1.06A 2h42B-5ng7A:
undetectable		 2h42B-5ng7A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 6 LEU A 170
ARG A 190
THR A 185
LEU A 184
 None
 1.08A 3abmA-5ng7A:
undetectable
3abmJ-5ng7A:
undetectable		 3abmA-5ng7A:
undetectable
3abmJ-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 6 LEU A 170
ARG A 190
THR A 185
LEU A 184
 None
 1.06A 3asnA-5ng7A:
undetectable
3asnJ-5ng7A:
undetectable		 3asnA-5ng7A:
undetectable
3asnJ-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		6 / 12 TYR A 148
ALA A 243
ILE A 244
VAL A 149
ILE A 218
MET A 133
 None
 1.28A 3b2rA-5ng7A:
undetectable		 3b2rA-5ng7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		6 / 11 TYR A 148
ALA A 243
ILE A 244
VAL A 149
ILE A 218
MET A 133
 None
 1.32A 3b2rB-5ng7A:
undetectable		 3b2rB-5ng7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		3 / 3 TYR A  62
TYR A 209
GLY A  33
 None
 0.75A 3eteB-5ng7A:
undetectable
3eteD-5ng7A:
undetectable
3eteF-5ng7A:
undetectable		 3eteB-5ng7A:
10.28
3eteD-5ng7A:
10.28
3eteF-5ng7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 5 VAL A  55
VAL A  54
ARG A  53
LYS A 120
 None
 1.26A 3rv5A-5ng7A:
undetectable
3rv5B-5ng7A:
undetectable		 3rv5A-5ng7A:
undetectable
3rv5B-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 12 GLY A  99
GLY A 104
GLY A 103
LEU A  30
VAL A  96
 None
 1.01A 4htfB-5ng7A:
2.2		 4htfB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 12 ASP A 101
TYR A 148
PHE A 152
TYR A 209
HIS A 270
 None
 0.60A 4j03A-5ng7A:
33.2		 4j03A-5ng7A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 12 TYR A 148
PHE A 152
TYR A 209
HIS A 270
TRP A 271
 None
 1.08A 4j03A-5ng7A:
33.2		 4j03A-5ng7A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 7 ASP A 101
PRO A  35
ASP A  36
HIS A 270
 None
 1.17A 4k7gB-5ng7A:
undetectable		 4k7gB-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		5 / 12 LEU A  30
LEU A  31
GLY A  99
VAL A  96
ILE A 236
 None
 1.16A 4ok1A-5ng7A:
undetectable		 4ok1A-5ng7A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5ng7 EPOXIDE HYDROLASE
(metagenome) 		4 / 6 LEU A 124
ASN A 125
LEU A 234
ILE A 249
 None
 1.11A 4okxA-5ng7A:
undetectable		 4okxA-5ng7A:
12.80