SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ngv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens) 		6 / 12 TYR L  38
PHE L 102
ASN H  35
VAL H  37
ALA H  97
TRP H 105
 None
 0.56A 1h8sA-5ngvL:
17.9		 1h8sA-5ngvL:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  95
TYR L  38
PRO L  46
TYR L  89
 None
 0.71A 2oldA-5ngvH:
15.3
2oldB-5ngvH:
15.3		 2oldA-5ngvH:
19.74
2oldB-5ngvH:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  38
PRO L  46
TYR L  89
TYR H  95
 None
 0.66A 2oldA-5ngvL:
20.7
2oldB-5ngvL:
20.7		 2oldA-5ngvL:
45.93
2oldB-5ngvL:
45.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
(Homo
sapiens) 		3 / 3 LYS H  12
LYS H  19
VAL H  18
 None
 1.10A 3brfA-5ngvH:
undetectable		 3brfA-5ngvH:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens) 		5 / 10 VAL L  29
GLY L  30
VAL L 101
ASN L  71
GLY L  24
 None
 1.29A 3km6A-5ngvL:
undetectable		 3km6A-5ngvL:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens) 		5 / 9 VAL L  29
GLY L  30
VAL L 101
ASN L  71
GLY L  24
 None
 1.31A 3kmoA-5ngvL:
undetectable		 3kmoA-5ngvL:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
(Homo
sapiens) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 104
 PCA  H   1 ( 3.4A)
None
None
None
 0.32A 4m7kH-5ngvH:
22.3		 4m7kH-5ngvH:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens) 		4 / 8 TYR L  38
GLY L  91
GLY L 100
PHE L 102
 None
 0.18A 5albL-5ngvL:
20.3		 5albL-5ngvL:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens) 		4 / 8 TYR L  38
GLY L  91
GLY L 100
PHE L 102
 None
 0.27A 5alcL-5ngvL:
20.3		 5alcL-5ngvL:
37.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
(Homo
sapiens) 		4 / 5 TYR H  60
GLN H  65
GLY H  99
ILE H  51
 None
 1.30A 6debB-5ngvH:
undetectable		 6debB-5ngvH:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
(Homo
sapiens) 		4 / 5 ARG H  72
ALA H  79
TYR H  80
ILE H  76
 None
 1.38A 6f6sA-5ngvH:
undetectable
6f6sB-5ngvH:
undetectable		 6f6sA-5ngvH:
18.18
6f6sB-5ngvH:
22.61