SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ngy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
6 / 12 TYR A1127
LEU A 629
LEU A 630
ASP A 677
ALA A 678
HIS A 789
None
1.11A 1dedA-5ngyA:
9.0
1dedA-5ngyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 TRP A 479
ARG A 453
THR A 478
None
0.86A 1df7A-5ngyA:
undetectable
1df7A-5ngyA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ILE A1062
HIS A 712
LEU A 734
VAL A 863
None
0.85A 1fslB-5ngyA:
undetectable
1fslB-5ngyA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 TYR A1234
THR A 659
TYR A1230
LEU A1135
None
1.34A 1uw6A-5ngyA:
undetectable
1uw6B-5ngyA:
undetectable
1uw6A-5ngyA:
11.02
1uw6B-5ngyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 TYR A1234
THR A 659
TYR A1230
LEU A1135
None
1.31A 1uw6D-5ngyA:
undetectable
1uw6E-5ngyA:
undetectable
1uw6D-5ngyA:
11.02
1uw6E-5ngyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 TYR A1234
THR A 659
TYR A1230
LEU A1135
None
1.32A 1uw6G-5ngyA:
undetectable
1uw6H-5ngyA:
undetectable
1uw6G-5ngyA:
11.02
1uw6H-5ngyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 TYR A1234
THR A 659
TYR A1230
LEU A1135
None
1.31A 1uw6P-5ngyA:
undetectable
1uw6Q-5ngyA:
undetectable
1uw6P-5ngyA:
11.02
1uw6Q-5ngyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 LEU A1135
TYR A1234
THR A 659
TYR A1230
None
1.32A 1uw6P-5ngyA:
undetectable
1uw6T-5ngyA:
undetectable
1uw6P-5ngyA:
11.02
1uw6T-5ngyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 PRO A 864
VAL A 943
SER A 851
VAL A1024
LEU A1022
None
1.44A 1z9hA-5ngyA:
undetectable
1z9hA-5ngyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 PRO A 864
VAL A 943
SER A 851
VAL A1024
LEU A1022
None
1.44A 1z9hB-5ngyA:
undetectable
1z9hB-5ngyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 PRO A 864
VAL A 943
SER A 851
VAL A1024
LEU A1022
None
1.43A 1z9hC-5ngyA:
undetectable
1z9hC-5ngyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ARG A 918
ARG A 896
TYR A1168
THR A1100
None
1.41A 1zlqB-5ngyA:
undetectable
1zlqB-5ngyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 6 LEU A 972
SER A 891
ASP A 887
GLU A 988
None
1.12A 2j2pE-5ngyA:
undetectable
2j2pF-5ngyA:
undetectable
2j2pE-5ngyA:
11.27
2j2pF-5ngyA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ASP A1225
SER A1221
TYR A1272
SER A1228
None
1.03A 2xz5C-5ngyA:
undetectable
2xz5D-5ngyA:
undetectable
2xz5C-5ngyA:
11.31
2xz5D-5ngyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 ASN A1277
SER A1276
ILE A1210
PHE A 582
GLU A 568
None
1.33A 2zq0A-5ngyA:
3.6
2zq0A-5ngyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_B_ACRB811_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 ASN A1277
SER A1276
ILE A1210
PHE A 582
GLU A 568
None
1.33A 2zq0B-5ngyA:
4.0
2zq0B-5ngyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 MET A 736
GLU A1064
ASN A1068
None
0.95A 3a27A-5ngyA:
undetectable
3a27A-5ngyA:
11.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.44A 3aicA-5ngyA:
57.1
3aicA-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.29A 3aicA-5ngyA:
57.1
3aicA-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.41A 3aicB-5ngyA:
56.3
3aicB-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.28A 3aicB-5ngyA:
56.3
3aicB-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
TYR A1127
GLN A1183
None
0.36A 3aicC-5ngyA:
57.7
3aicC-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.41A 3aicD-5ngyA:
57.8
3aicD-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.44A 3aicE-5ngyA:
57.8
3aicE-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.31A 3aicE-5ngyA:
57.9
3aicE-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.46A 3aicF-5ngyA:
57.1
3aicF-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.37A 3aicF-5ngyA:
57.1
3aicF-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.41A 3aicG-5ngyA:
57.9
3aicG-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.26A 3aicG-5ngyA:
57.9
3aicG-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
9 / 12 LEU A 629
ARG A 675
ASP A 677
ALA A 678
ASN A 681
HIS A 789
ASP A 790
ASP A1118
GLN A1183
None
0.43A 3aicH-5ngyA:
57.8
3aicH-5ngyA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 LEU A 630
TRP A 717
TYR A1127
None
0.28A 3aicH-5ngyA:
57.8
3aicH-5ngyA:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 GLY A 938
GLY A 902
GLY A 920
None
0.38A 3bogD-5ngyA:
undetectable
3bogD-5ngyA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 TYR A 853
GLU A1064
ASP A 677
None
0.85A 3bxoA-5ngyA:
undetectable
3bxoA-5ngyA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 GLY A1012
GLY A1020
SER A1019
ILE A1010
ASN A 948
None
1.07A 3cjtG-5ngyA:
undetectable
3cjtG-5ngyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 9 GLY A1114
ALA A1119
ASP A1118
GLY A 631
THR A1130
None
1.05A 3gguB-5ngyA:
undetectable
3gguB-5ngyA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 ASP A 721
ASP A 680
TYR A 626
GLN A 606
None
1.19A 3l2vA-5ngyA:
undetectable
3l2vA-5ngyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 9 PHE A1102
VAL A1175
ILE A1087
ALA A1158
ALA A1164
None
1.26A 3mdtA-5ngyA:
undetectable
3mdtA-5ngyA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 LEU A 352
GLY A 328
ILE A 344
GLY A 341
ILE A 314
None
0.96A 3nu3A-5ngyA:
undetectable
3nu3A-5ngyA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 ALA A 430
ALA A 431
LEU A1287
LEU A1308
TYR A 434
None
1.02A 3p2kD-5ngyA:
undetectable
3p2kD-5ngyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ASP A 721
ASP A 680
TYR A 626
GLN A 606
None
1.03A 3s3mA-5ngyA:
undetectable
3s3mA-5ngyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ASP A 721
ASP A 680
TYR A 626
GLN A 606
None
0.96A 3s3nA-5ngyA:
undetectable
3s3nA-5ngyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 ASP A 721
ASP A 680
TYR A 626
GLN A 606
None
0.97A 3s3oA-5ngyA:
undetectable
3s3oA-5ngyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 GLY A 562
THR A 564
ASN A 560
None
0.71A 3v4tD-5ngyA:
undetectable
3v4tD-5ngyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 TYR A 867
SER A1067
THR A 883
TYR A 831
ASN A 832
None
1.45A 4dajC-5ngyA:
undetectable
4dajC-5ngyA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 ASP A 623
PRO A 604
ASP A 721
SER A 718
None
0.91A 4k7gB-5ngyA:
undetectable
4k7gB-5ngyA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ASP A1289
SER A1332
SER A1317
TYR A1336
None
1.04A 4lv9A-5ngyA:
1.8
4lv9B-5ngyA:
undetectable
4lv9A-5ngyA:
17.31
4lv9B-5ngyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 TYR A1336
ASP A1289
SER A1332
SER A1317
None
1.05A 4lv9A-5ngyA:
1.8
4lv9B-5ngyA:
undetectable
4lv9A-5ngyA:
17.31
4lv9B-5ngyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 4 ASN A1125
GLY A1126
ASP A 680
ASP A1178
None
1.40A 4n49A-5ngyA:
undetectable
4n49A-5ngyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 ASN A1284
ILE A1214
ILE A1213
VAL A1195
None
0.85A 4ojbA-5ngyA:
undetectable
4ojbA-5ngyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 LEU A 893
LEU A 973
THR A 858
ILE A 939
VAL A 941
None
1.12A 4ok1A-5ngyA:
undetectable
4ok1A-5ngyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 6 ASN A1284
ILE A1214
ILE A1213
VAL A1195
None
0.94A 4olmA-5ngyA:
undetectable
4olmA-5ngyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 5 ASP A 685
LEU A 686
ARG A1132
THR A1255
None
1.47A 4p3qA-5ngyA:
undetectable
4p3qA-5ngyA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
6 / 12 GLY A 631
ASP A 633
ASN A1274
ILE A 581
ILE A1278
ILE A 565
None
CA  A1501 (-2.3A)
None
None
None
None
1.46A 4q5mA-5ngyA:
undetectable
4q5mA-5ngyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 PHE A1248
TYR A 693
GLY A1232
ILE A1265
None
1.00A 4qoiA-5ngyA:
undetectable
4qoiB-5ngyA:
1.9
4qoiA-5ngyA:
10.00
4qoiB-5ngyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 SER A 757
ASP A 756
GLN A 743
LYS A 763
None
0.85A 4umjA-5ngyA:
undetectable
4umjA-5ngyA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 11 ASN A 720
SER A 718
ASP A 680
ILE A 612
THR A 603
None
1.41A 4urnA-5ngyA:
undetectable
4urnA-5ngyA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 11 ASN A 720
SER A 718
ASP A 680
ILE A 612
THR A 603
None
1.42A 4urnB-5ngyA:
undetectable
4urnB-5ngyA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 7 ALA A1338
ARG A1370
GLY A1385
THR A1363
None
0.80A 5btdA-5ngyA:
undetectable
5btdB-5ngyA:
undetectable
5btdC-5ngyA:
undetectable
5btdA-5ngyA:
17.87
5btdB-5ngyA:
12.22
5btdC-5ngyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 6 ALA A1338
ARG A1370
GLY A1385
THR A1363
None
0.78A 5btgA-5ngyA:
undetectable
5btgB-5ngyA:
undetectable
5btgC-5ngyA:
undetectable
5btgA-5ngyA:
17.87
5btgB-5ngyA:
12.22
5btgC-5ngyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 5 ALA A1056
PRO A 864
GLY A 869
LEU A 893
None
1.01A 5eslA-5ngyA:
undetectable
5eslA-5ngyA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 ILE A 786
LEU A 744
VAL A 943
LEU A1022
TYR A 885
None
0.95A 5ienA-5ngyA:
undetectable
5ienA-5ngyA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 5 ILE A1087
ILE A1173
HIS A1163
VAL A1175
None
0.89A 5jmnA-5ngyA:
undetectable
5jmnA-5ngyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ARG A 918
ARG A 896
TYR A1168
THR A1100
None
1.38A 5l8dA-5ngyA:
undetectable
5l8dA-5ngyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 SER A1332
TYR A1331
TYR A1330
None
0.65A 5lakA-5ngyA:
undetectable
5lakI-5ngyA:
undetectable
5lakA-5ngyA:
13.44
5lakI-5ngyA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 SER A1332
TYR A1331
TYR A1330
None
0.62A 5lakC-5ngyA:
undetectable
5lakJ-5ngyA:
undetectable
5lakC-5ngyA:
13.44
5lakJ-5ngyA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ARG A 918
ARG A 896
TYR A1168
THR A1100
None
1.38A 5mwuA-5ngyA:
undetectable
5mwuA-5ngyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
6 / 12 ILE A1087
PHE A1066
GLN A1103
ILE A1159
ALA A1158
VAL A1175
None
1.18A 5n0sB-5ngyA:
undetectable
5n0sB-5ngyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 ILE A1087
PHE A1066
GLN A1103
ALA A1158
VAL A1175
None
1.27A 5n0xB-5ngyA:
undetectable
5n0xB-5ngyA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 4 ARG A 787
ILE A 786
TYR A 853
ILE A 889
None
1.47A 5odhG-5ngyA:
undetectable
5odhG-5ngyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
3 / 3 VAL A 302
TYR A 294
GLN A 293
None
0.75A 5qgrA-5ngyA:
undetectable
5qgrA-5ngyA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
6 / 12 TYR A1127
TYR A 626
LEU A 629
ASP A 677
HIS A 789
ASP A 790
None
0.81A 6ag0A-5ngyA:
11.0
6ag0A-5ngyA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 TYR A 626
LEU A 629
ASP A 677
HIS A 789
ASP A 790
None
0.82A 6ag0C-5ngyA:
11.0
6ag0C-5ngyA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 GLY A1029
SER A 901
LYS A 921
GLN A 937
ASP A1032
None
1.37A 6bxlA-5ngyA:
undetectable
6bxlA-5ngyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
5 / 12 GLY A1029
SER A 901
LYS A 921
GLN A 937
ASP A1032
None
1.35A 6bxlB-5ngyA:
undetectable
6bxlB-5ngyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 4 LEU A 629
ASP A1182
GLN A1183
VAL A 812
None
CA  A1501 (-3.3A)
None
None
1.48A 6bzoF-5ngyA:
undetectable
6bzoF-5ngyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ARG A 787
GLU A 792
ARG A 865
GLN A1103
None
1.22A 6fbvD-5ngyA:
undetectable
6fbvD-5ngyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum)
4 / 8 ASP A 204
TYR A 180
GLY A 215
VAL A 218
None
GLC  A1507 (-3.8A)
None
None
0.98A 6giqL-5ngyA:
undetectable
6giqP-5ngyA:
undetectable
6giqT-5ngyA:
undetectable
6giqL-5ngyA:
17.24
6giqP-5ngyA:
10.84
6giqT-5ngyA:
4.32