SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		3 / 3 VAL A  36
VAL A  17
TRP A  31
 None
 0.96A 1w5uA-5nh0A:
undetectable
1w5uB-5nh0A:
undetectable		 1w5uA-5nh0A:
undetectable
1w5uB-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		3 / 3 VAL A  17
TRP A  31
VAL A  36
 None
 0.99A 2izqC-5nh0A:
undetectable
2izqD-5nh0A:
undetectable		 2izqC-5nh0A:
undetectable
2izqD-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		4 / 7 PRO A  39
GLY A 174
VAL A 181
SER A  84
 None
 0.93A 4a3uB-5nh0A:
undetectable		 4a3uB-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		4 / 4 THR A  25
LEU A  27
HIS A  41
GLY A 142
 8X8  A 301 ( 4.5A)
None
8X8  A 301 (-3.5A)
8X8  A 301 (-3.4A)
 0.33A 5gwyA-5nh0A:
20.9		 5gwyA-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		4 / 6 VAL A  18
HIS A  69
LEU A  74
CYH A  16
 None
 1.08A 5hrqB-5nh0A:
undetectable
5hrqI-5nh0A:
undetectable
5hrqJ-5nh0A:
undetectable		 5hrqB-5nh0A:
undetectable
5hrqI-5nh0A:
undetectable
5hrqJ-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		5 / 11 GLN A 267
ASN A 231
VAL A 204
SER A 201
ASP A 202
 None
None
None
None
DMS  A 302 (-3.8A)
 1.47A 5jh7D-5nh0A:
undetectable		 5jh7D-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		4 / 8 TRP A 233
GLN A 267
ALA A 236
HIS A 270
 None
 1.05A 5km8A-5nh0A:
undetectable
5km8B-5nh0A:
undetectable		 5km8A-5nh0A:
18.57
5km8B-5nh0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5nh0 REPLICASE
POLYPROTEIN 1AB
(Human
coronavirus
NL63) 		5 / 12 PHE A 185
GLU A 194
GLY A 170
SER A 169
ARG A 130
 None
None
None
None
DMS  A 303 (-3.5A)
 1.15A 5w7pA-5nh0A:
undetectable		 5w7pA-5nh0A:
undetectable