SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		3 / 3 ALA A 438
VAL A 440
TRP A 439
 None
 0.72A 1bdwA-5nh1A:
undetectable
1bdwB-5nh1A:
undetectable		 1bdwA-5nh1A:
7.83
1bdwB-5nh1A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3002_1
(SERUM ALBUMIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 9 LEU A 447
LEU A 469
ARG A 465
LEU A 388
SER A 382
 None
 1.21A 1hk1A-5nh1A:
0.1		 1hk1A-5nh1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		4 / 8 LEU A 447
LEU A 469
LEU A 388
SER A 382
 None
 1.05A 1hk2A-5nh1A:
undetectable		 1hk2A-5nh1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 VAL A 352
LEU A 356
LEU A 479
LEU A 312
LEU A 475
 None
 1.04A 1mx1F-5nh1A:
undetectable		 1mx1F-5nh1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		4 / 7 GLY A 350
ALA A 332
ALA A 328
VAL A 342
 None
 0.70A 3a2qA-5nh1A:
undetectable		 3a2qA-5nh1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		4 / 5 SER A 382
LEU A 442
GLY A 446
GLU A 444
 None
 1.18A 3aiaA-5nh1A:
undetectable
3aiaB-5nh1A:
undetectable		 3aiaA-5nh1A:
23.01
3aiaB-5nh1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 LEU A 393
LEU A 313
LEU A 312
HIS A 386
LEU A 389
 None
 1.17A 3erdA-5nh1A:
undetectable		 3erdA-5nh1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 LEU A 479
LEU A 320
LEU A 353
ALA A 328
ALA A 332
 None
 1.09A 3vw7A-5nh1A:
undetectable		 3vw7A-5nh1A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 SER A 472
LEU A 441
HIS A 386
LEU A 326
LEU A 374
 None
 1.42A 4o8fB-5nh1A:
undetectable		 4o8fB-5nh1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 11 LEU A 367
ALA A 368
LEU A 363
MET A 362
LEU A 358
 None
 1.17A 5dxgB-5nh1A:
undetectable		 5dxgB-5nh1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		4 / 8 HIS A 386
GLN A 323
LEU A 389
LEU A 320
 None
 1.16A 5hs6A-5nh1A:
undetectable		 5hs6A-5nh1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0B-5nh1A:
undetectable		 6ew0B-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0D-5nh1A:
undetectable		 6ew0D-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0F-5nh1A:
undetectable		 6ew0F-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0G-5nh1A:
undetectable		 6ew0G-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0H-5nh1A:
undetectable		 6ew0H-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5nh1 GASDERMIN-D
(Homo
sapiens) 		5 / 12 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0I-5nh1A:
undetectable		 6ew0I-5nh1A:
15.71