SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 10 HIS A 102
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.42A 1xidA-5nhbA:
40.7		 1xidA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 10 TRP A  50
HIS A 102
PHE A 146
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.35A 1xidA-5nhbA:
40.7		 1xidA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.31A 1xihA-5nhbA:
40.6		 1xihA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
HIS A 272
ASP A 308
ASP A 297
 None
None
None
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
FE2  A 501 (-3.0A)
 1.34A 1xihA-5nhbA:
40.6		 1xihA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
PHE A 146
VAL A 187
TRP A 189
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.47A 1xihA-5nhbA:
40.6		 1xihA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 12 TRP A  50
HIS A 102
THR A 142
PHE A 146
VAL A 187
TRP A 189
LYS A 235
HIS A 272
ASP A 308
 None
None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
 0.82A 1xihA-5nhbA:
40.6		 1xihA-5nhbA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 11 ALA A 155
GLU A 193
PHE A 188
ILE A 175
THR A 157
 None
 1.21A 2w3aA-5nhbA:
undetectable		 2w3aA-5nhbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		3 / 3 GLU A 193
GLN A 170
ARG A 166
 None
 0.95A 2w3bB-5nhbA:
undetectable		 2w3bB-5nhbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.38A 2xinA-5nhbA:
40.4		 2xinA-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 233
GLU A 269
HIS A 272
ASP A 310
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 ( 3.9A)
 1.40A 2xinA-5nhbA:
40.4		 2xinA-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.57A 2xinA-5nhbA:
40.4		 2xinA-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
HIS A 272
ASP A 308
ASP A 297
 None
None
None
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
FE2  A 501 (-3.0A)
 1.12A 2xinB-5nhbA:
40.3		 2xinB-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		8 / 12 HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 310
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 ( 3.9A)
 1.44A 2xinB-5nhbA:
40.3		 2xinB-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.18A 2xinB-5nhbA:
40.3		 2xinB-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.53A 2xinB-5nhbA:
40.3		 2xinB-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.65A 2xinB-5nhbA:
40.3		 2xinB-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 308
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
FE2  A 501 (-3.0A)
 1.26A 2xinC-5nhbA:
40.4		 2xinC-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		8 / 12 HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 310
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 ( 3.9A)
 1.46A 2xinC-5nhbA:
40.4		 2xinC-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 THR A 142
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.31A 2xinC-5nhbA:
40.4		 2xinC-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.62A 2xinC-5nhbA:
40.4		 2xinC-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 308
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
FE2  A 501 (-3.0A)
 1.27A 2xinD-5nhbA:
40.4		 2xinD-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		8 / 12 HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 310
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 502 ( 3.9A)
 1.43A 2xinD-5nhbA:
40.4		 2xinD-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.17A 2xinD-5nhbA:
40.4		 2xinD-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.64A 2xinD-5nhbA:
40.4		 2xinD-5nhbA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		3 / 3 GLU A 117
ASP A 176
TYR A 220
 None
 0.81A 2yvlB-5nhbA:
undetectable		 2yvlB-5nhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 10 VAL A 164
ALA A 155
ILE A 175
ILE A 168
THR A 157
 None
 1.25A 3hbbD-5nhbA:
undetectable		 3hbbD-5nhbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		3 / 3 GLU A 269
GLU A 233
TRP A  50
 FE2  A 502 ( 2.3A)
FE2  A 501 (-2.2A)
None
 1.23A 3hrdA-5nhbA:
undetectable
3hrdE-5nhbA:
undetectable
3hrdF-5nhbA:
undetectable		 3hrdA-5nhbA:
21.10
3hrdE-5nhbA:
21.10
3hrdF-5nhbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 5 ILE A 252
HIS A 278
GLU A 283
HIS A 282
 None
 1.02A 3ljgA-5nhbA:
undetectable		 3ljgA-5nhbA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 LEU A 350
PHE A   6
ILE A  90
ALA A  86
 None
 1.04A 3mdrA-5nhbA:
undetectable		 3mdrA-5nhbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 7 ALA A 143
TYR A 151
ARG A 192
ALA A 155
 None
 1.10A 3twpA-5nhbA:
undetectable		 3twpA-5nhbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.29A 3ximA-5nhbA:
40.4		 3ximA-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 269
ASP A 297
ASP A 310
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 501 (-3.0A)
FE2  A 502 ( 3.9A)
 1.26A 3ximA-5nhbA:
40.4		 3ximA-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.57A 3ximA-5nhbA:
40.4		 3ximA-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.33A 3ximB-5nhbA:
40.4		 3ximB-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 310
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.30A 3ximB-5nhbA:
40.4		 3ximB-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.56A 3ximB-5nhbA:
40.4		 3ximB-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.21A 3ximC-5nhbA:
40.2		 3ximC-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.34A 3ximC-5nhbA:
40.2		 3ximC-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 310
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.24A 3ximC-5nhbA:
40.2		 3ximC-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.50A 3ximC-5nhbA:
40.2		 3ximC-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.28A 3ximD-5nhbA:
40.3		 3ximD-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 297
ASP A 310
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 501 (-3.0A)
FE2  A 502 ( 3.9A)
 1.23A 3ximD-5nhbA:
40.3		 3ximD-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.54A 3ximD-5nhbA:
40.3		 3ximD-5nhbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 10 HIS A  51
ASP A 310
ASP A 308
PRO A 236
HIS A 272
 None
FE2  A 502 ( 3.9A)
FE2  A 502 (-3.2A)
None
FE2  A 502 (-3.6A)
 1.40A 4bz6A-5nhbA:
undetectable		 4bz6A-5nhbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 HIS A  51
ASP A 310
ASP A 308
PRO A 236
HIS A 272
 None
FE2  A 502 ( 3.9A)
FE2  A 502 (-3.2A)
None
FE2  A 502 (-3.6A)
 1.40A 4bz6A-5nhbA:
undetectable
4bz6B-5nhbA:
undetectable		 4bz6A-5nhbA:
20.70
4bz6B-5nhbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 10 HIS A  51
ASP A 310
ASP A 308
PRO A 236
HIS A 272
 None
FE2  A 502 ( 3.9A)
FE2  A 502 (-3.2A)
None
FE2  A 502 (-3.6A)
 1.42A 4bz6D-5nhbA:
undetectable		 4bz6D-5nhbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
VAL A 187
ASN A 267
GLU A 269
ASP A 297
ASP A 310
 None
None
None
None
FE2  A 502 ( 2.3A)
FE2  A 501 (-3.0A)
FE2  A 502 ( 3.9A)
 1.33A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.44A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
ASN A 267
GLU A 269
HIS A 272
ASP A 297
ASP A 308
 None
None
None
None
None
FE2  A 502 ( 4.1A)
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
 0.47A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 10 LEU A 255
GLY A 291
ALA A 290
ASP A 289
ILE A 268
ILE A 252
 None
 1.38A 4ll3B-5nhbA:
undetectable		 4ll3B-5nhbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 10 LEU A 255
GLY A 291
ALA A 290
ASP A 289
ILE A 268
ILE A 252
 None
 1.40A 4ll3A-5nhbA:
undetectable		 4ll3A-5nhbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 ASP A 103
ASN A 173
ALA A 177
ASP A 105
 None
 1.00A 4mdaA-5nhbA:
undetectable		 4mdaA-5nhbA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 337
GLY A 335
ASN A 185
ILE A 326
ASN A 338
 None
 1.32A 4pooA-5nhbA:
undetectable		 4pooA-5nhbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.30A 4xiaA-5nhbA:
40.1		 4xiaA-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
HIS A 272
ASP A 308
ASP A 297
 None
None
None
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
FE2  A 501 (-3.0A)
 1.32A 4xiaA-5nhbA:
40.1		 4xiaA-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		10 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.49A 4xiaA-5nhbA:
40.1		 4xiaA-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		8 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
HIS A 272
ASP A 308
 None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 (-3.6A)
FE2  A 502 (-3.2A)
 0.82A 4xiaA-5nhbA:
40.1		 4xiaA-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.29A 4xiaB-5nhbA:
40.0		 4xiaB-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.36A 4xiaB-5nhbA:
40.0		 4xiaB-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.49A 4xiaB-5nhbA:
40.0		 4xiaB-5nhbA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 10 PHE A 339
ALA A 363
ASP A 362
TYR A  28
GLY A 360
 None
 1.19A 4xp1A-5nhbA:
undetectable		 4xp1A-5nhbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 PHE A  25
LYS A  13
TYR A  28
ALA A  30
 None
 1.15A 4yshB-5nhbA:
undetectable		 4yshB-5nhbA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 8 TRP A 189
GLU A 233
ASP A 310
TRP A  50
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 3.9A)
None
 1.00A 5kf8A-5nhbA:
undetectable		 5kf8A-5nhbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 5 TRP A 189
GLU A 233
ASP A 310
TRP A  50
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 3.9A)
None
 1.01A 5kgjA-5nhbA:
0.7		 5kgjA-5nhbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 8 TRP A 189
GLU A 233
ASP A 310
TRP A  50
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 3.9A)
None
 0.97A 5kgpA-5nhbA:
1.0		 5kgpA-5nhbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 8 TRP A 189
GLU A 233
ASP A 310
TRP A  50
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 3.9A)
None
 0.99A 5kgpB-5nhbA:
undetectable		 5kgpB-5nhbA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 9 HIS A 102
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.37A 5nhaA-5nhbA:
66.4		 5nhaA-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 9 TRP A  50
HIS A 102
TRP A 140
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.20A 5nhaA-5nhbA:
66.4		 5nhaA-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 9 HIS A 102
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.40A 5nhaB-5nhbA:
66.4		 5nhaB-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 9 HIS A 102
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.38A 5nhaB-5nhbA:
66.4		 5nhaB-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 9 TRP A  50
HIS A 102
TRP A 140
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.20A 5nhaB-5nhbA:
66.4		 5nhaB-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 9 HIS A 102
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.38A 5nhaC-5nhbA:
66.3		 5nhaC-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 9 TRP A  50
HIS A 102
TRP A 140
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.20A 5nhaC-5nhbA:
66.3		 5nhaC-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 9 HIS A 102
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.39A 5nhaD-5nhbA:
66.4		 5nhaD-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 9 HIS A 102
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.39A 5nhaD-5nhbA:
66.4		 5nhaD-5nhbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		9 / 9 TRP A  50
HIS A 102
TRP A 140
TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 297
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 501 ( 3.2A)
 0.19A 5nhaD-5nhbA:
66.4		 5nhaD-5nhbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 ALA A 183
ALA A 363
ALA A 365
MET A  91
THR A 334
 None
 0.84A 5tl8A-5nhbA:
undetectable		 5tl8A-5nhbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.48A 5ximA-5nhbA:
40.4		 5ximA-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 HIS A 102
THR A 142
GLU A 269
ASP A 310
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
FE2  A 501 (-3.0A)
 1.48A 5ximA-5nhbA:
40.4		 5ximA-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.27A 5ximA-5nhbA:
40.4		 5ximA-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 310
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.27A 5ximA-5nhbA:
40.4		 5ximA-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.51A 5ximA-5nhbA:
40.4		 5ximA-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 HIS A 102
THR A 142
GLU A 269
ASP A 310
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
FE2  A 501 (-3.0A)
 1.50A 5ximB-5nhbA:
40.4		 5ximB-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.31A 5ximB-5nhbA:
40.4		 5ximB-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 269
ASP A 310
 None
None
None
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.41A 5ximB-5nhbA:
40.4		 5ximB-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.58A 5ximB-5nhbA:
40.4		 5ximB-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 HIS A 102
THR A 142
GLU A 269
ASP A 310
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
FE2  A 501 (-3.0A)
 1.40A 5ximC-5nhbA:
40.3		 5ximC-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		7 / 12 HIS A 102
THR A 142
TRP A 189
LYS A 235
GLU A 269
HIS A 272
ASP A 297
 None
None
None
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.19A 5ximC-5nhbA:
40.3		 5ximC-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		6 / 12 HIS A 102
THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 310
 None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.29A 5ximC-5nhbA:
40.3		 5ximC-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		12 / 12 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.52A 5ximC-5nhbA:
40.3		 5ximC-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 297
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
 1.34A 5ximD-5nhbA:
40.4		 5ximD-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 THR A 142
VAL A 187
GLU A 233
GLU A 269
ASP A 310
 None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 ( 3.9A)
 1.23A 5ximD-5nhbA:
40.4		 5ximD-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		11 / 12 TRP A  50
THR A 142
VAL A 187
TRP A 189
GLU A 233
LYS A 235
GLU A 269
HIS A 272
ASP A 297
ASP A 308
ASP A 340
 None
None
None
None
FE2  A 501 (-2.2A)
FE2  A 502 ( 4.1A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
FE2  A 501 ( 3.2A)
 0.53A 5ximD-5nhbA:
40.4		 5ximD-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		5 / 12 TRP A 189
GLU A 233
GLU A 269
HIS A 272
ASP A 340
 None
FE2  A 501 (-2.2A)
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.22A 5ximD-5nhbA:
40.4		 5ximD-5nhbA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 TYR A 151
ALA A 165
ARG A 166
ASP A 103
 None
 1.11A 6hu9m-5nhbA:
undetectable
6hu9q-5nhbA:
undetectable		 6hu9m-5nhbA:
20.90
6hu9q-5nhbA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.41A 6mn5A-5nhbA:
undetectable		 6mn5A-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.43A 6mn5C-5nhbA:
undetectable		 6mn5C-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 6 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.41A 6mn5D-5nhbA:
undetectable		 6mn5D-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_F_LLLF301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nhb XYLOSE ISOMERASE
(Piromyces
sp.
E2) 		4 / 5 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.28A 6mn5F-5nhbA:
0.0		 6mn5F-5nhbA:
12.37