SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 12 LEU A 147
GLY A 181
PRO A 183
ILE A 155
VAL A 218
 None
 1.12A 1tmxB-5nhsA:
undetectable		 1tmxB-5nhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 12 VAL A 238
LEU A 217
VAL A 174
GLY A 229
LEU A 246
 None
 1.14A 2cbrA-5nhsA:
undetectable		 2cbrA-5nhsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 12 THR A 268
GLY A  17
MET A 184
VAL A 241
ALA A 220
 None
 1.04A 3t7vA-5nhsA:
undetectable		 3t7vA-5nhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 10 ALA A  34
PRO A  43
ILE A  72
ILE A 287
ASP A 291
 None
 1.20A 4dtaA-5nhsA:
undetectable		 4dtaA-5nhsA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 9 ILE A  20
GLY A 154
LEU A 147
LEU A 159
LEU A 188
 None
 1.11A 5fhzB-5nhsA:
2.4		 5fhzB-5nhsA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 10 ILE A  20
GLY A 154
LEU A 147
LEU A 159
LEU A 188
 None
 1.10A 5fhzC-5nhsA:
3.7		 5fhzC-5nhsA:
10.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 12 GLN A 107
LEU A 108
PRO A 109
ASP A 130
THR A 278
 None
 0.90A 6debB-5nhsA:
25.3		 6debB-5nhsA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 10 SER A  56
LEU A 119
ASP A 130
ILE A 113
PRO A 111
 None
 1.37A 6dlzB-5nhsA:
3.5
6dlzC-5nhsA:
4.1		 6dlzB-5nhsA:
19.51
6dlzC-5nhsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 11 ILE A 113
PRO A 111
SER A  56
LEU A 119
ASP A 130
 None
 1.38A 6dlzA-5nhsA:
3.6
6dlzD-5nhsA:
3.9		 6dlzA-5nhsA:
19.51
6dlzD-5nhsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 10 SER A  56
LEU A 119
ASP A 130
ILE A 113
PRO A 111
 None
 1.37A 6dm1B-5nhsA:
3.7
6dm1C-5nhsA:
4.1		 6dm1B-5nhsA:
19.51
6dm1C-5nhsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nhs BIFUNCTIONAL PROTEIN
FOLD
(Xanthomonas
albilineans) 		5 / 11 ILE A 113
PRO A 111
SER A  56
LEU A 119
ASP A 130
 None
 1.38A 6dm1A-5nhsA:
4.1
6dm1D-5nhsA:
2.8		 6dm1A-5nhsA:
19.51
6dm1D-5nhsA:
19.51