SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 ALA A  48
LEU A  38
LEU A  78
SER A  73
LEU A  15
 None
 1.04A 1qzfA-5nhxA:
undetectable		 1qzfA-5nhxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 ALA A  48
LEU A  38
LEU A  78
SER A  73
LEU A  15
 None
 1.04A 1qzfB-5nhxA:
undetectable		 1qzfB-5nhxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 ALA A  48
LEU A  38
LEU A  78
SER A  73
LEU A  15
 None
 1.04A 1qzfC-5nhxA:
undetectable		 1qzfC-5nhxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 ALA A  48
LEU A  38
LEU A  78
SER A  73
LEU A  15
 None
 1.04A 1qzfD-5nhxA:
undetectable		 1qzfD-5nhxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 ALA A  48
LEU A  38
LEU A  78
SER A  73
LEU A  15
 None
 1.04A 1qzfE-5nhxA:
undetectable		 1qzfE-5nhxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		4 / 8 LEU A  34
VAL A  50
VAL A 127
LEU A  10
 None
 1.10A 3v81C-5nhxA:
undetectable		 3v81C-5nhxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		4 / 8 LEU A  34
VAL A  50
VAL A 127
LEU A  10
 None
 1.12A 4pwdC-5nhxA:
undetectable		 4pwdC-5nhxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		3 / 3 ARG A  56
ARG A 121
ARG A 110
 None
 1.00A 5vcgA-5nhxA:
undetectable		 5vcgA-5nhxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5nhx OUTER MEMBRANE
PROTEIN A
(Klebsiella
pneumoniae) 		5 / 12 PHE A  16
PHE A   8
ALA A  21
ILE A  83
LEU A  31
 None
 1.17A 6aybA-5nhxA:
undetectable		 6aybA-5nhxA:
12.64