SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.17A 1gtfJ-5niiA:
undetectable
1gtfK-5niiA:
undetectable		 1gtfJ-5niiA:
undetectable
1gtfK-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 ALA A 284
THR A 256
ILE A 105
GLY A 249
THR A 268
 None
None
None
None
NA  A 402 (-3.5A)
 1.15A 1utdE-5niiA:
undetectable
1utdF-5niiA:
undetectable		 1utdE-5niiA:
undetectable
1utdF-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 ALA A 284
THR A 256
ILE A 105
GLY A 249
THR A 268
 None
None
None
None
NA  A 402 (-3.5A)
 1.15A 1utdH-5niiA:
undetectable
1utdI-5niiA:
undetectable		 1utdH-5niiA:
undetectable
1utdI-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 9 LEU A 210
GLU A 202
ILE A 198
GLY A 215
SER A 208
 None
 1.14A 2qmmA-5niiA:
2.4		 2qmmA-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		6 / 11 LEU A 210
GLU A 202
ILE A 198
GLY A 215
SER A 208
LEU A 207
 None
 1.24A 2qmmA-5niiA:
2.4
2qmmB-5niiA:
2.2		 2qmmA-5niiA:
undetectable
2qmmB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 7 ALA A  14
ALA A  18
THR A  22
LEU A   6
 FAD  A 401 (-3.3A)
None
None
None
 0.95A 2wx2A-5niiA:
undetectable		 2wx2A-5niiA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 8 ALA A  14
ALA A  18
THR A  22
LEU A   6
 FAD  A 401 (-3.3A)
None
None
None
 1.01A 2wx2B-5niiA:
undetectable		 2wx2B-5niiA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 8 ALA A  14
ALA A  18
THR A  22
LEU A   6
 FAD  A 401 (-3.3A)
None
None
None
 0.90A 3khmA-5niiA:
undetectable		 3khmA-5niiA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 223
ALA A 220
GLU A 218
ARG A 196
ILE A 225
 None
 1.18A 3olsB-5niiA:
undetectable		 3olsB-5niiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  64
LEU A  16
THR A  29
 GOL  A 405 (-4.3A)
None
None
 0.82A 3oxcA-5niiA:
undetectable		 3oxcA-5niiA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 9 PRO A 115
LEU A 201
LEU A 207
ILE A 225
MET A 227
 None
 1.49A 4c66A-5niiA:
undetectable		 4c66A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ALA A 264
GLY A  10
GLY A  15
ILE A  92
THR A  93
 None
FAD  A 401 (-3.3A)
None
None
None
 1.03A 4n49A-5niiA:
undetectable		 4n49A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 148
ALA A 226
GLU A 229
SER A 177
ILE A 178
 None
 1.09A 4pb1A-5niiA:
undetectable		 4pb1A-5niiA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 148
ALA A 226
GLU A 229
SER A 177
ILE A 178
 None
 1.07A 4pd9A-5niiA:
undetectable		 4pd9A-5niiA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 8 ALA A 264
GLY A 281
ALA A  18
GLY A  15
 None
 0.69A 4zjzA-5niiA:
undetectable		 4zjzA-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.15A 5eevA-5niiA:
undetectable
5eevB-5niiA:
undetectable		 5eevA-5niiA:
undetectable
5eevB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5eewA-5niiA:
undetectable
5eewB-5niiA:
undetectable		 5eewA-5niiA:
undetectable
5eewB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.15A 5eexA-5niiA:
undetectable
5eexB-5niiA:
undetectable		 5eexA-5niiA:
undetectable
5eexB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5eeyA-5niiA:
undetectable
5eeyB-5niiA:
undetectable		 5eeyA-5niiA:
undetectable
5eeyB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5eezA-5niiA:
undetectable
5eezB-5niiA:
undetectable		 5eezA-5niiA:
undetectable
5eezB-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5ef0A-5niiA:
undetectable
5ef0B-5niiA:
undetectable		 5ef0A-5niiA:
undetectable
5ef0B-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.15A 5ef1A-5niiA:
undetectable
5ef1B-5niiA:
undetectable		 5ef1A-5niiA:
undetectable
5ef1B-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5ef2A-5niiA:
undetectable
5ef2B-5niiA:
undetectable		 5ef2A-5niiA:
undetectable
5ef2B-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 GLY A 249
THR A 268
ALA A 284
THR A 256
ILE A 105
 None
NA  A 402 (-3.5A)
None
None
None
 1.16A 5ef3A-5niiA:
undetectable
5ef3B-5niiA:
undetectable		 5ef3A-5niiA:
undetectable
5ef3B-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 105
GLY A  10
ALA A  72
ILE A  92
PHE A  90
 None
FAD  A 401 (-3.3A)
None
None
None
 1.08A 5ih0A-5niiA:
undetectable		 5ih0A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 7 LEU A 201
THR A 171
ASP A 194
LEU A 207
 None
 1.06A 5jq7B-5niiA:
undetectable		 5jq7B-5niiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		4 / 7 ASP A 135
PHE A 138
GLY A 127
GLY A 125
 GOL  A 409 (-3.5A)
None
None
None
 0.97A 5n9xA-5niiA:
3.0		 5n9xA-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 ALA A 277
ALA A 264
ALA A  14
GLY A 270
GLY A 269
 FAD  A 401 ( 3.7A)
None
FAD  A 401 (-3.3A)
NA  A 402 (-4.7A)
NA  A 402 (-4.1A)
 0.94A 6hwdK-5niiA:
undetectable
6hwdL-5niiA:
undetectable		 6hwdK-5niiA:
24.71
6hwdL-5niiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5nii THIOREDOXIN
REDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 ALA A 277
ALA A 264
ALA A  14
GLY A 270
GLY A 269
 FAD  A 401 ( 3.7A)
None
FAD  A 401 (-3.3A)
NA  A 402 (-4.7A)
NA  A 402 (-4.1A)
 0.94A 6hwdY-5niiA:
undetectable
6hwdZ-5niiA:
undetectable		 6hwdY-5niiA:
24.71
6hwdZ-5niiA:
23.86