SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 LEU A 183
SER A 175
ASN A  72
 None
SNN  A 176 ( 3.4A)
CIT  A 502 (-3.8A)
 0.82A 1bx4A-5nijA:
3.0		 1bx4A-5nijA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 TRP A  71
VAL A 383
TRP A 485
 CIT  A 502 ( 4.9A)
None
CIT  A 502 (-4.0A)
 1.16A 1c4dA-5nijA:
undetectable
1c4dB-5nijA:
undetectable		 1c4dA-5nijA:
undetectable
1c4dB-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 GLN A 475
ILE A 393
HIS A 452
 None
 0.75A 1fm9A-5nijA:
undetectable		 1fm9A-5nijA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 7 LEU A  85
MET A 328
LEU A 324
GLU A 287
 None
 1.05A 1linA-5nijA:
undetectable		 1linA-5nijA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 SER A 221
GLY A 179
VAL A 182
ILE A 450
HIS A  75
 None
None
None
None
SNN  A 176 ( 3.3A)
 1.16A 1vhwA-5nijA:
undetectable
1vhwD-5nijA:
undetectable		 1vhwA-5nijA:
14.57
1vhwD-5nijA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 SER A 221
GLY A 179
VAL A 182
ILE A 450
HIS A  75
 None
None
None
None
SNN  A 176 ( 3.3A)
 1.20A 1vhwC-5nijA:
undetectable
1vhwE-5nijA:
undetectable		 1vhwC-5nijA:
14.57
1vhwE-5nijA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 HIS A  75
SER A 221
GLY A 179
VAL A 182
ILE A 450
 SNN  A 176 ( 3.3A)
None
None
None
None
 1.21A 1vhwA-5nijA:
undetectable
1vhwD-5nijA:
undetectable		 1vhwA-5nijA:
14.57
1vhwD-5nijA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 HIS A  75
SER A 221
GLY A 179
VAL A 182
ILE A 450
 SNN  A 176 ( 3.3A)
None
None
None
None
 1.16A 1vhwC-5nijA:
undetectable
1vhwE-5nijA:
undetectable		 1vhwC-5nijA:
14.57
1vhwE-5nijA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
 None
 1.17A 1xdkB-5nijA:
undetectable		 1xdkB-5nijA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 PHE A 214
LEU A 191
ILE A 224
PHE A 225
GLY A  66
 None
None
None
None
SNN  A 176 ( 3.7A)
 1.21A 2lbdA-5nijA:
undetectable		 2lbdA-5nijA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A  65
ASP A 358
GLY A 249
LEU A 270
ASP A  78
 None
CIT  A 502 (-3.6A)
None
None
None
 1.26A 2nv4B-5nijA:
undetectable		 2nv4B-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 ASP A 141
PHE A 144
LEU A 148
 None
 0.34A 2zi9A-5nijA:
undetectable		 2zi9A-5nijA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 GLU A 220
GLY A 249
ALA A  65
ASP A 358
GLY A 184
 None
None
None
CIT  A 502 (-3.6A)
SNN  A 176 ( 3.5A)
 0.84A 3jzjA-5nijA:
undetectable		 3jzjA-5nijA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 10 VAL A  64
ALA A  61
TYR A 174
ILE A 172
ILE A  79
 None
None
SNN  A 176 ( 4.4A)
None
None
 1.21A 3retA-5nijA:
undetectable
3retB-5nijA:
undetectable		 3retA-5nijA:
15.84
3retB-5nijA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.98A 3t3zA-5nijA:
undetectable		 3t3zA-5nijA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.97A 3t3zB-5nijA:
undetectable		 3t3zB-5nijA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.90A 3t3zD-5nijA:
undetectable		 3t3zD-5nijA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 9 TYR A 307
GLY A 308
HIS A 310
GLU A 245
ARG A 350
 None
None
SO4  A 501 (-4.0A)
None
None
 1.50A 4dprA-5nijA:
undetectable		 4dprA-5nijA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 HIS A 121
ILE A 117
ASP A  78
GLY A 268
ALA A  82
 None
 1.25A 4fqsA-5nijA:
undetectable		 4fqsA-5nijA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 LEU A 431
LEU A 196
TRP A 428
TYR A 192
MET A 453
 None
 1.45A 4hwkD-5nijA:
undetectable		 4hwkD-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A 218
ALA A 193
ILE A 224
GLY A  66
GLN A 447
 SNN  A 176 ( 4.2A)
None
None
SNN  A 176 ( 3.7A)
SNN  A 176 (-3.0A)
 1.24A 4r38B-5nijA:
undetectable		 4r38B-5nijA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 VAL A 125
PHE A 173
ILE A  79
SER A 175
ASN A 118
 None
None
None
SNN  A 176 ( 3.4A)
None
 1.41A 5hgcA-5nijA:
undetectable		 5hgcA-5nijA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 LYS A 210
GLN A 285
ASN A 323
 None
 1.04A 5l2tA-5nijA:
undetectable		 5l2tA-5nijA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 5 LEU A  85
PHE A 171
LEU A  91
TRP A 275
 None
 1.39A 5m10A-5nijA:
undetectable		 5m10A-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 TYR A 327
ASP A 325
ASP A 322
 None
 0.62A 5x6yA-5nijA:
2.9		 5x6yA-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 9 VAL A 383
TYR A 366
GLU A 378
GLY A 372
PRO A 370
 None
 1.30A 5zniA-5nijA:
2.0		 5zniA-5nijA:
18.89