SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
5 / 12 ALA A 329
ASN A 304
SER A 303
TYR A 242
TYR A 160
None
1.46A 1xvaB-5nj6A:
undetectable
1xvaB-5nj6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
4 / 5 VAL A 322
SER A  65
VAL A  68
SER A 320
None
1.21A 2j9cA-5nj6A:
undetectable
2j9cB-5nj6A:
undetectable
2j9cC-5nj6A:
undetectable
2j9cA-5nj6A:
13.50
2j9cB-5nj6A:
13.50
2j9cC-5nj6A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
4 / 7 TYR A 242
GLN A 214
TYR A 160
ILE A 202
None
1.25A 2ph9A-5nj6A:
undetectable
2ph9B-5nj6A:
undetectable
2ph9A-5nj6A:
17.50
2ph9B-5nj6A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
5 / 10 ALA A2035
ALA A2034
ALA A2039
VAL A2015
ILE A2016
None
1.10A 3falA-5nj6A:
undetectable
3falA-5nj6A:
19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
6 / 12 TYR A 156
TYR A 160
LEU A 209
HIS A 227
LEU A 307
TYR A 326
None
1.33A 3vw7A-5nj6A:
33.1
3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
6 / 12 TYR A 156
TYR A 160
LEU A 209
LEU A 230
LEU A 307
TYR A 326
None
1.39A 3vw7A-5nj6A:
33.1
3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
6 / 12 TYR A 160
LEU A 209
HIS A 227
LEU A 306
LEU A 307
TYR A 326
None
1.21A 3vw7A-5nj6A:
33.1
3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
5 / 12 TYR A 160
PHE A 243
LEU A 306
LEU A 307
TYR A 311
None
1.09A 3vw7A-5nj6A:
33.1
3vw7A-5nj6A:
34.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
5 / 12 ILE A2016
ALA A2074
GLN A2070
THR A2096
LEU A2013
None
1.38A 4qzuA-5nj6A:
undetectable
4qzuA-5nj6A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
3 / 3 ALA A 157
TYR A 160
PRO A 208
None
0.66A 4zdyA-5nj6A:
undetectable
4zdyA-5nj6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
4 / 6 TYR A 156
ASP A 228
HIS A 227
TYR A  82
None
1.16A 5ih0A-5nj6A:
undetectable
5ih0A-5nj6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo
sapiens)
4 / 7 LEU A 166
TRP A 199
ALA A 120
LEU A 119
None
1.04A 5nwvA-5nj6A:
undetectable
5nwvA-5nj6A:
5.95