SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5njf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 ALA B 227
VAL B 222
TRP B 221
 None
 0.83A 1kqeA-5njfB:
undetectable
1kqeE-5njfB:
undetectable		 1kqeA-5njfB:
2.41
1kqeE-5njfB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 ALA B 227
VAL B 222
TRP B 221
 None
 0.81A 1kqeB-5njfB:
undetectable
1kqeD-5njfB:
undetectable		 1kqeB-5njfB:
2.41
1kqeD-5njfB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 TRP B 221
ALA B 227
VAL B 222
 None
 0.83A 1kqeB-5njfB:
undetectable
1kqeD-5njfB:
undetectable		 1kqeB-5njfB:
2.41
1kqeD-5njfB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 TRP B 221
ALA B 227
VAL B 222
 None
 0.81A 1kqeA-5njfB:
undetectable
1kqeE-5njfB:
undetectable		 1kqeA-5njfB:
2.41
1kqeE-5njfB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 9 THR A 174
ILE A 166
ARG A 180
ILE A 311
ASP A 178
 None
 1.11A 1nb9A-5njfA:
undetectable		 1nb9A-5njfA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 8 VAL A 221
ARG A  53
GLU A 147
ASP A 224
 None
 1.13A 1s3zA-5njfA:
undetectable
1s3zB-5njfA:
undetectable		 1s3zA-5njfA:
19.87
1s3zB-5njfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 6 LEU A 185
ALA A 157
LEU A 159
VAL A 155
 None
 1.04A 1sn5A-5njfA:
undetectable		 1sn5A-5njfA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 6 LEU A  25
PHE A  22
ALA A  23
LEU A  38
 None
 1.01A 1ukbA-5njfA:
undetectable		 1ukbA-5njfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 ARG B 271
TYR B 270
LYS B 336
 None
 0.73A 1uujB-5njfB:
undetectable		 1uujB-5njfB:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 7 PHE A  40
LEU A 167
ILE A  24
ASP A  20
 None
 0.92A 1yc2E-5njfA:
undetectable		 1yc2E-5njfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 8 ASP A 298
GLY A 268
PHE A 281
TYR A 332
 None
 0.95A 2aouA-5njfA:
undetectable		 2aouA-5njfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 5 TYR B 205
SER B 190
TYR B 207
ARG B 229
 None
 1.48A 2kqeA-5njfB:
undetectable		 2kqeA-5njfB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		3 / 3 PRO A 361
ASN A 338
ARG A 275
 None
 1.06A 2qeuB-5njfA:
undetectable		 2qeuB-5njfA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 6 LEU B 328
LEU B 329
ILE B 318
ARG B 316
 None
 1.04A 2rlfA-5njfB:
undetectable
2rlfB-5njfB:
undetectable		 2rlfA-5njfB:
8.55
2rlfB-5njfB:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 10 THR B 410
SER B 389
ALA A 425
GLY A 479
ALA A 245
 None
 1.35A 2xh9B-5njfB:
2.3		 2xh9B-5njfB:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 7 TYR B  71
SER B  33
ILE B  68
SER B 175
 None
 1.25A 2xz5A-5njfB:
undetectable
2xz5B-5njfB:
undetectable		 2xz5A-5njfB:
18.57
2xz5B-5njfB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		5 / 12 LEU B 376
ARG B 390
PHE B 257
GLY B 258
ASN B 434
 None
 1.42A 2zznB-5njfB:
undetectable		 2zznB-5njfB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5njf METALLOPROTEASE TLDD
METALLOPROTEASE PMBA
(Escherichia
coli;
Escherichia
coli) 		3 / 3 MET A 360
GLU B  59
ASN B 164
 None
 1.07A 3a27A-5njfA:
undetectable		 3a27A-5njfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 4 ARG B  15
ASP B  63
GLY B  45
THR B 185
 None
 1.50A 3k4vB-5njfB:
undetectable		 3k4vB-5njfB:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 5 HIS B 187
SER B 214
ASP B 125
THR B 185
 None
 1.38A 3okxA-5njfB:
undetectable		 3okxA-5njfB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 5 HIS B 187
SER B 214
ASP B 125
THR B 185
 None
 1.36A 3okxB-5njfB:
undetectable		 3okxB-5njfB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 8 GLY A  65
ILE A 166
TYR A  39
ASP A  37
 None
 0.78A 3pwwA-5njfA:
undetectable		 3pwwA-5njfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 GLN B 450
GLU B 408
LYS B 238
 None
 0.65A 3su9A-5njfB:
undetectable		 3su9A-5njfB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		3 / 3 TYR B 388
MET B 242
LEU B 371
 None
 0.68A 3vw1D-5njfB:
undetectable		 3vw1D-5njfB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 6 THR A 347
ASN A 349
GLY A 350
ASP A 335
 None
 1.16A 3w9tE-5njfA:
undetectable		 3w9tE-5njfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 9 GLY A 204
GLY A 205
PHE A 212
SER A 202
GLY A 203
 None
 0.99A 3ztvA-5njfA:
undetectable		 3ztvA-5njfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 12 LEU A   3
GLY A 315
GLY A 348
LEU A 175
GLY A 173
 None
 1.04A 4blvA-5njfA:
undetectable		 4blvA-5njfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		5 / 10 ALA B 263
ILE B 264
ILE B 319
LEU B 285
ILE B 284
 None
 1.18A 4dtaA-5njfB:
undetectable		 4dtaA-5njfB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.30A 4qvlV-5njfA:
undetectable
4qvlb-5njfA:
undetectable		 4qvlV-5njfA:
19.24
4qvlb-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.30A 4qvlH-5njfA:
undetectable
4qvlN-5njfA:
undetectable		 4qvlH-5njfA:
19.24
4qvlN-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.32A 4qvwV-5njfA:
undetectable
4qvwb-5njfA:
undetectable		 4qvwV-5njfA:
19.24
4qvwb-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.33A 4qvwH-5njfA:
undetectable
4qvwN-5njfA:
undetectable		 4qvwH-5njfA:
19.24
4qvwN-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.34A 4qw1V-5njfA:
undetectable
4qw1b-5njfA:
undetectable		 4qw1V-5njfA:
19.24
4qw1b-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.34A 4qw1H-5njfA:
undetectable
4qw1N-5njfA:
undetectable		 4qw1H-5njfA:
19.24
4qw1N-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.35A 4qwuV-5njfA:
undetectable
4qwub-5njfA:
undetectable		 4qwuV-5njfA:
19.24
4qwub-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 10 VAL A 396
GLY A 392
PHE A 405
GLY B 378
MET B 377
 None
 1.38A 4xpbA-5njfA:
undetectable		 4xpbA-5njfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 6 LEU A 185
ALA A 157
LEU A 159
VAL A 155
 None
 1.28A 5a6iA-5njfA:
undetectable		 5a6iA-5njfA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.32A 5bxnV-5njfA:
undetectable
5bxnb-5njfA:
undetectable		 5bxnV-5njfA:
19.19
5bxnb-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.32A 5bxnH-5njfA:
undetectable
5bxnN-5njfA:
undetectable		 5bxnH-5njfA:
19.19
5bxnN-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 PHE A 391
THR A 434
VAL A 472
VAL A 251
LEU A 427
 None
 1.46A 5jkwA-5njfA:
undetectable		 5jkwA-5njfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5njf METALLOPROTEASE TLDD
METALLOPROTEASE PMBA
(Escherichia
coli;
Escherichia
coli) 		3 / 3 GLN A  64
THR B  82
ASP A  63
 None
 0.92A 5k9dA-5njfA:
undetectable		 5k9dA-5njfA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.35A 5l66V-5njfA:
undetectable
5l66b-5njfA:
undetectable		 5l66V-5njfA:
19.24
5l66b-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5njf METALLOPROTEASE PMBA
METALLOPROTEASE TLDD
(Escherichia
coli) 		5 / 11 THR A 426
LYS B 238
GLY A 246
ALA B 448
THR B 241
 None
 1.35A 5l66H-5njfA:
undetectable
5l66N-5njfA:
undetectable		 5l66H-5njfA:
19.24
5l66N-5njfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 8 THR B 290
THR B 325
ARG B 316
GLN B 326
 None
 1.06A 5tzoA-5njfB:
undetectable		 5tzoA-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 8 THR B 290
THR B 325
ARG B 316
GLN B 326
 None
 1.10A 5tzoB-5njfB:
undetectable		 5tzoB-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5njf METALLOPROTEASE PMBA
(Escherichia
coli) 		4 / 8 THR B 290
THR B 325
ARG B 316
GLN B 326
 None
 1.09A 5tzoC-5njfB:
undetectable		 5tzoC-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 4 VAL A 250
LEU A 260
ASN A 474
ASP A 473
 None
 1.28A 5vcyA-5njfA:
undetectable		 5vcyA-5njfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5njf METALLOPROTEASE TLDD
METALLOPROTEASE PMBA
(Escherichia
coli;
Escherichia
coli) 		5 / 12 VAL A 250
GLY A 478
ILE B 447
ALA B 412
ALA A 245
 None
 1.12A 5x7fA-5njfA:
undetectable		 5x7fA-5njfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 5 MET A 302
TYR A 367
GLY A 466
GLY A 255
 None
 1.01A 5x7pA-5njfA:
undetectable		 5x7pA-5njfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 6 MET A 302
TYR A 367
GLY A 466
GLY A 255
 None
 0.98A 5x7pB-5njfA:
undetectable		 5x7pB-5njfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 4 VAL A 168
GLY A 315
ASP A 312
ASP A 178
 None
 1.49A 6cjkC-5njfA:
undetectable		 6cjkC-5njfA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 5 ARG A 207
ARG A 305
GLY A 307
ASN A 365
 None
 1.33A 6dwjB-5njfA:
undetectable
6dwjD-5njfA:
undetectable		 6dwjB-5njfA:
23.64
6dwjD-5njfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5njf METALLOPROTEASE TLDD
(Escherichia
coli) 		4 / 5 ARG A 306
ARG A 305
GLY A 464
ASN A 365
 None
 1.01A 6dwjB-5njfA:
undetectable
6dwjD-5njfA:
undetectable		 6dwjB-5njfA:
23.64
6dwjD-5njfA:
23.64