SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5njj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 112
LEU A  95
GLY A  94
VAL A 158
ALA A 157
 None
 1.15A 4foxD-5njjA:
undetectable		 4foxD-5njjA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 112
LEU A  95
GLY A  94
VAL A 158
ALA A 157
 None
 1.23A 4fqsA-5njjA:
undetectable		 4fqsA-5njjA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 112
LEU A  95
GLY A  94
VAL A 158
ALA A 157
 None
 1.24A 4fqsB-5njjA:
undetectable		 4fqsB-5njjA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		3 / 4 ARG A  33
GLY A  31
GLU A  30
 None
 0.63A 4z2dB-5njjA:
undetectable
4z2dC-5njjA:
undetectable		 4z2dB-5njjA:
10.85
4z2dC-5njjA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		5 / 12 GLN A 109
VAL A  90
PHE A  39
HIS A  46
VAL A  62
 None
 1.23A 5ergB-5njjA:
undetectable		 5ergB-5njjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 140
CYH A 141
LEU A  65
HIS A  46
 None
 1.37A 5hrqC-5njjA:
undetectable
5hrqD-5njjA:
undetectable
5hrqL-5njjA:
undetectable		 5hrqC-5njjA:
undetectable
5hrqD-5njjA:
undetectable
5hrqL-5njjA:
undetectable