SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5njl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		4 / 5 LEU A 165
ALA A 132
LEU A 130
SER A 127
 None
None
None
SO4  A 420 (-3.4A)
 1.10A 1tt6B-5njlA:
undetectable		 1tt6B-5njlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		4 / 6 LEU A 232
LEU A  50
ILE A  65
HIS A 108
 None
None
None
SO4  A 402 (-3.9A)
 0.93A 1yajF-5njlA:
undetectable		 1yajF-5njlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		5 / 12 ILE A  83
ILE A  68
ILE A  79
LEU A  89
VAL A  44
 None
None
SO4  A 410 (-3.6A)
None
None
 1.18A 3fpjB-5njlA:
undetectable		 3fpjB-5njlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		5 / 12 ALA A 156
LEU A 165
VAL A 213
ILE A 216
LEU A 192
 None
 0.98A 3h0aA-5njlA:
undetectable		 3h0aA-5njlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		4 / 8 LEU A 169
VAL A 151
TYR A 149
LEU A 219
 None
 1.10A 4pwdC-5njlA:
undetectable		 4pwdC-5njlA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)
(Clostridioides
difficile) 		4 / 5 ASP A 229
THR A 104
GLN A 231
GLU A  67
 SO4  A 405 (-3.5A)
None
None
None
 1.08A 5k9dA-5njlA:
undetectable		 5k9dA-5njlA:
22.25