SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 LEU A 443
VAL A 438
GLY A 437
VAL A 343
 None
 0.82A 1t88A-5nkpA:
undetectable		 1t88A-5nkpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 10 ARG A 339
THR A 386
TYR A 449
ARG A 528
TYR A 577
 CL  A 602 (-4.2A)
CL  A 602 (-3.8A)
None
None
None
 1.02A 1v3eA-5nkpA:
12.7		 1v3eA-5nkpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 TYR A 444
VAL A 439
VAL A 509
GLY A 490
 None
 1.10A 3kmoB-5nkpA:
undetectable		 3kmoB-5nkpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A 413
VAL A 411
TRP A 470
 None
 0.84A 3l8lA-5nkpA:
undetectable
3l8lB-5nkpA:
undetectable		 3l8lA-5nkpA:
9.71
3l8lB-5nkpA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 GLN A 309
PHE A 355
ARG A 431
GLY A 354
SER A 385
 None
None
None
None
CL  A 602 (-2.9A)
 1.29A 3sueD-5nkpA:
undetectable		 3sueD-5nkpA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 6 PHE A 355
ARG A 339
LEU A 359
SER A 385
 None
CL  A 602 (-4.2A)
None
CL  A 602 (-2.9A)
 1.39A 3vlnA-5nkpA:
undetectable		 3vlnA-5nkpA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 VAL A 302
TYR A 540
CYH A 533
ILE A 583
 None
 0.89A 4afgD-5nkpA:
undetectable
4afgE-5nkpA:
undetectable		 4afgD-5nkpA:
19.93
4afgE-5nkpA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 GLY A 543
ALA A 530
ASN A 550
SER A 572
GLN A 329
 None
None
CL  A 603 ( 4.4A)
None
None
 1.23A 4rtpA-5nkpA:
undetectable		 4rtpA-5nkpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 GLY A 579
TYR A 540
TYR A 577
SER A 576
ALA A 340
 None
 1.43A 4ymgA-5nkpA:
undetectable		 4ymgA-5nkpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A 445
TYR A 444
PRO A 465
 None
 0.67A 4zdyA-5nkpA:
undetectable		 4zdyA-5nkpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A 494
TYR A 493
PRO A 512
 None
 0.63A 4zdyA-5nkpA:
undetectable		 4zdyA-5nkpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 GLY A 401
TYR A 397
ALA A 390
GLY A 388
 None
 0.86A 5albL-5nkpA:
undetectable		 5albL-5nkpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 9 GLN A 309
GLY A 307
SER A 316
GLU A 318
ALA A 351
 None
 1.28A 5entC-5nkpA:
undetectable		 5entC-5nkpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 443
LYS A 442
ASN A 393
LEU A 395
ALA A 413
 None
 1.40A 5kbwA-5nkpA:
undetectable		 5kbwA-5nkpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 TYR A 463
ALA A 413
TYR A 397
 None
 0.62A 5uunB-5nkpA:
undetectable		 5uunB-5nkpA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 4 VAL A 439
LYS A 442
VAL A 460
ASN A 515
 None
 1.32A 5vc3A-5nkpA:
2.4		 5vc3A-5nkpA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 VAL A 446
VAL A 399
GLY A 437
TYR A 444
 None
 0.88A 5x80C-5nkpA:
undetectable
5x80D-5nkpA:
undetectable		 5x80C-5nkpA:
19.73
5x80D-5nkpA:
19.73