SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 7 LEU D  91
SER D  88
ASP D  86
PHE D  94
 None
 1.11A 1ismB-5nkzD:
undetectable		 1ismB-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5nkz PEROXIN 22
(Ogataea
angusta) 		3 / 3 ASN D  95
ALA D  68
ASN D  72
 None
 0.77A 1n4fA-5nkzD:
undetectable		 1n4fA-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5nkz PEROXIN 22
(Ogataea
angusta) 		3 / 3 ASN D 130
LEU D 131
HIS D  82
 None
 0.77A 2q6fB-5nkzD:
undetectable		 2q6fB-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 7 ASN D 124
LEU D 143
ASP D 144
SER D 121
 None
 1.37A 3lslA-5nkzD:
2.7
3lslD-5nkzD:
2.8		 3lslA-5nkzD:
undetectable
3lslD-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 7 SER D 121
ASN D 124
LEU D 143
ASP D 144
 None
 1.34A 3lslA-5nkzD:
2.7
3lslD-5nkzD:
2.8		 3lslA-5nkzD:
undetectable
3lslD-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 7 GLU D  89
VAL D  85
PHE D  94
LEU D  71
 None
 0.81A 3qeoB-5nkzD:
undetectable		 3qeoB-5nkzD:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		4 / 6 TYR A 169
PHE A  56
PRO A  55
LEU A 144
 None
 1.27A 3tgvB-5nkzA:
undetectable		 3tgvB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		4 / 6 TYR A 169
PHE A  56
PRO A  55
LEU A 144
 None
 1.37A 3tgvD-5nkzA:
undetectable		 3tgvD-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 5 HIS D 114
SER D 111
THR D 108
GLU D 139
 None
 1.40A 3tm4A-5nkzD:
undetectable		 3tm4A-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5nkz PEROXIN 22
(Ogataea
angusta) 		4 / 5 HIS D 114
SER D 111
THR D 108
GLU D 139
 None
 1.40A 3tm4B-5nkzD:
undetectable		 3tm4B-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		5 / 12 VAL A  15
TYR A  71
ILE A  65
GLN A 134
LEU A 137
 None
 1.23A 4o5fA-5nkzA:
undetectable
4o5fB-5nkzA:
undetectable		 4o5fA-5nkzA:
undetectable
4o5fB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		5 / 12 GLN A 134
LEU A 137
VAL A  15
TYR A  71
ILE A  65
 None
 1.24A 4o5fA-5nkzA:
undetectable
4o5fB-5nkzA:
undetectable		 4o5fA-5nkzA:
undetectable
4o5fB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nkz PEROXIN 22
(Ogataea
angusta) 		5 / 9 ILE D 123
LEU D  81
VAL D 115
LEU D 119
ILE D 104
 None
 1.28A 4r38C-5nkzD:
undetectable		 4r38C-5nkzD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		5 / 12 VAL A  15
TYR A  71
ILE A  65
GLN A 134
LEU A 137
 None
 1.26A 5b8hA-5nkzA:
undetectable
5b8hB-5nkzA:
undetectable		 5b8hA-5nkzA:
undetectable
5b8hB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		5 / 12 GLN A 134
LEU A 137
VAL A  15
TYR A  71
ILE A  65
 None
 1.23A 5b8hA-5nkzA:
undetectable
5b8hB-5nkzA:
undetectable		 5b8hA-5nkzA:
undetectable
5b8hB-5nkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		4 / 5 LEU A  63
LEU A 123
PHE A  80
LEU A 143
 None
 1.03A 5gtrA-5nkzA:
undetectable		 5gtrA-5nkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Ogataea
angusta) 		4 / 5 ILE A  26
SER A  24
ALA A  14
LEU A  34
 None
 0.97A 6dwnA-5nkzA:
undetectable		 6dwnA-5nkzA:
19.78