SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5nl1 TALIN-1
(Mus
musculus) 		4 / 7 LYS A 535
LEU A 593
GLU A 538
LEU A 522
 None
 0.99A 1sn0B-5nl1A:
undetectable
1sn0D-5nl1A:
undetectable		 1sn0B-5nl1A:
22.90
1sn0D-5nl1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5nl1 TALIN-1
(Mus
musculus) 		5 / 12 SER A 582
SER A 581
SER A 502
ALA A 626
THR A 561
 None
 1.31A 2nniA-5nl1A:
2.6		 2nniA-5nl1A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nl1 TALIN-1
(Mus
musculus) 		5 / 5 LEU A 593
LYS A 592
ALA A 595
LEU A 598
LEU A 609
 None
 1.35A 5vkqA-5nl1A:
4.0
5vkqD-5nl1A:
4.0		 5vkqA-5nl1A:
undetectable
5vkqD-5nl1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nl1 TALIN-1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.34A 5vkqA-5nl1A:
4.0
5vkqB-5nl1A:
4.0		 5vkqA-5nl1A:
undetectable
5vkqB-5nl1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nl1 TALIN-1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.34A 5vkqB-5nl1A:
4.0
5vkqC-5nl1A:
4.0		 5vkqB-5nl1A:
undetectable
5vkqC-5nl1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nl1 TALIN-1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.34A 5vkqC-5nl1A:
4.0
5vkqD-5nl1A:
4.0		 5vkqC-5nl1A:
undetectable
5vkqD-5nl1A:
undetectable