SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ALA A  27
VAL A  22
TRP A  21
 None
 0.82A 1kqeA-5nl7A:
undetectable
1kqeE-5nl7A:
undetectable		 1kqeA-5nl7A:
undetectable
1kqeE-5nl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ALA A  27
VAL A  22
TRP A  21
 None
 0.80A 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable		 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 TRP A  21
ALA A  27
VAL A  22
 None
 0.82A 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable		 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 TRP A  21
ALA A  27
VAL A  22
 None
 0.81A 1kqeA-5nl7A:
undetectable
1kqeE-5nl7A:
undetectable		 1kqeA-5nl7A:
undetectable
1kqeE-5nl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 PHE A  80
LEU A  78
ALA A  77
LEU A 107
LEU A  49
 None
 1.19A 1og5A-5nl7A:
undetectable		 1og5A-5nl7A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 10 PHE A 228
LEU A 162
VAL A 158
PHE A 153
VAL A 221
 None
 1.42A 1q23E-5nl7A:
undetectable		 1q23E-5nl7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 ALA A 191
ILE A 197
GLY A 196
LEU A 224
ALA A 223
 None
 1.21A 3kw2A-5nl7A:
undetectable		 3kw2A-5nl7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 ALA A 191
ILE A 197
GLY A 196
LEU A 224
ALA A 223
 None
 1.22A 3kw2B-5nl7A:
undetectable		 3kw2B-5nl7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 PHE A  40
VAL A 108
ILE A 112
GLU A  45
ILE A  58
 None
 1.19A 4a97B-5nl7A:
undetectable
4a97C-5nl7A:
undetectable		 4a97B-5nl7A:
13.99
4a97C-5nl7A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 LEU A  49
VAL A  22
PHE A  40
THR A 104
GLY A 106
 None
 1.35A 6brdA-5nl7A:
undetectable		 6brdA-5nl7A:
22.35