SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 TRP A  92
HIS A  93
LEU A  94
LEU A  97
 None
 1.31A 1hz4A-5nlaA:
undetectable		 1hz4A-5nlaA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 5 LEU A 185
VAL A 235
CYH A 234
ALA A 198
 None
 1.12A 1mz9D-5nlaA:
undetectable		 1mz9D-5nlaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 LEU A 185
VAL A 235
CYH A 234
ALA A 198
 None
 1.23A 1mz9E-5nlaA:
undetectable		 1mz9E-5nlaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 TRP A 135
GLU A 144
ARG A 153
VAL A 192
 None
 1.40A 1rs6A-5nlaA:
undetectable
1rs6B-5nlaA:
undetectable		 1rs6A-5nlaA:
21.37
1rs6B-5nlaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 SER A 168
LEU A  89
LEU A  70
MET A  67
HIS A 107
 None
 1.40A 1zgyA-5nlaA:
undetectable		 1zgyA-5nlaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		3 / 3 LEU A 171
MET A 173
MET A  67
 None
 0.56A 2vavF-5nlaA:
undetectable		 2vavF-5nlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 ARG A 302
GLN A 305
TYR A 258
THR A 272
 None
 1.26A 2vxaF-5nlaA:
undetectable
2vxaG-5nlaA:
undetectable
2vxaI-5nlaA:
undetectable		 2vxaF-5nlaA:
11.75
2vxaG-5nlaA:
11.75
2vxaI-5nlaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 LEU A 261
SER A 265
ASN A 264
THR A 272
 None
 1.00A 3lm8B-5nlaA:
undetectable
3lm8D-5nlaA:
undetectable		 3lm8B-5nlaA:
18.93
3lm8D-5nlaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 LEU A 155
TYR A 109
GLY A 161
SER A 134
LEU A  70
 None
 1.39A 3okxA-5nlaA:
undetectable		 3okxA-5nlaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 THR A 136
SER A 134
PHE A 129
LEU A  70
PHE A 172
 None
 1.48A 3u9fE-5nlaA:
undetectable		 3u9fE-5nlaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 SER A 168
LEU A  89
LEU A  70
MET A  67
HIS A 107
 None
 1.45A 3vn2A-5nlaA:
undetectable		 3vn2A-5nlaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 5 ARG A 239
GLY A 187
ALA A 188
GLY A 183
 None
 0.79A 4u9uB-5nlaA:
undetectable		 4u9uB-5nlaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 TRP A 135
GLU A 144
ARG A 153
VAL A 192
 None
 1.41A 4uchA-5nlaA:
undetectable
4uchB-5nlaA:
undetectable		 4uchA-5nlaA:
19.41
4uchB-5nlaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 ALA A 167
PRO A  86
LEU A  75
HIS A 107
 None
 1.45A 5eskA-5nlaA:
undetectable		 5eskA-5nlaA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 ILE A 205
GLY A 213
ASN A 214
ILE A  99
 None
 0.94A 5j4nB-5nlaA:
undetectable		 5j4nB-5nlaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		4 / 5 ARG A  64
TRP A  63
ALA A  65
PRO A  69
 None
 1.48A 5syiA-5nlaA:
0.1		 5syiA-5nlaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN
(Sinorhizobium
meliloti) 		3 / 3 GLU A 209
LEU A 212
ARG A  48
 None
 0.81A 6d8fA-5nlaA:
undetectable		 6d8fA-5nlaA:
19.82