SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		5 / 12 PHE A 298
LEU A 284
ILE A 299
VAL A 146
ALA A 320
 None
 1.16A 2g72B-5nmwA:
undetectable		 2g72B-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 8 ILE A 309
TYR A  95
ASP A 312
ARG A  18
 None
 1.06A 2v57C-5nmwA:
undetectable		 2v57C-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 8 TYR A 240
SER A 238
SER A 249
HIS A 243
 None
 1.15A 2vmyA-5nmwA:
undetectable
2vmyB-5nmwA:
undetectable		 2vmyA-5nmwA:
undetectable
2vmyB-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 6 THR A  15
VAL A 318
VAL A  27
VAL A   4
 None
 0.99A 2z97A-5nmwA:
undetectable		 2z97A-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 4 GLN A 314
PHE A 311
TYR A 303
VAL A 145
 None
FAD  A 500 (-4.6A)
None
None
 1.50A 3keeA-5nmwA:
0.0		 3keeA-5nmwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 8 LEU A 355
GLN A 314
TYR A 362
PHE A 363
 None
 1.07A 3po7A-5nmwA:
12.1		 3po7A-5nmwA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		4 / 6 SER A 139
HIS A 114
THR A 128
ARG A 119
 None
FAD  A 500 (-3.6A)
None
None
 1.40A 3thrB-5nmwA:
undetectable		 3thrB-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		5 / 12 GLY A  13
GLY A  10
LEU A 105
VAL A   6
VAL A  27
 None
FAD  A 500 (-3.3A)
None
None
None
 0.96A 4htfA-5nmwA:
3.0		 4htfA-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		6 / 12 GLY A  13
GLY A  10
LEU A 105
ALA A  16
VAL A  29
VAL A  27
 None
FAD  A 500 (-3.3A)
None
None
None
None
 1.38A 4htfB-5nmwA:
undetectable		 4htfB-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		5 / 12 GLY A  13
GLY A  10
LEU A 105
VAL A   6
VAL A  27
 None
FAD  A 500 (-3.3A)
None
None
None
 0.96A 4htfB-5nmwA:
undetectable		 4htfB-5nmwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		5 / 12 LEU A 188
ILE A 255
GLY A 191
SER A 213
LEU A 234
 None
 1.03A 4lmnA-5nmwA:
undetectable		 4lmnA-5nmwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5nmw FLAVIN-CONTAINING
MONOOXYGENASE
(Zonocerus
variegatus) 		3 / 3 ARG A 335
PRO A 283
ASN A 290
 None
 1.07A 5jwaA-5nmwA:
10.1
5jwaH-5nmwA:
10.0		 5jwaA-5nmwA:
undetectable
5jwaH-5nmwA:
undetectable