SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 752
ALA A 724
LEU A 712
ILE A 824
PRO A 825
 None
 1.05A 1drfA-5nn8A:
undetectable		 1drfA-5nn8A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 937
LEU A 901
VAL A 845
ALA A 880
ILE A 823
 CSO  A 938 ( 3.9A)
None
None
None
None
 1.00A 1epbA-5nn8A:
undetectable		 1epbA-5nn8A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 9 PHE A 767
SER A 800
GLY A 770
ARG A 819
LEU A 751
 None
 1.48A 1jb0A-5nn8A:
undetectable		 1jb0A-5nn8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 TYR A 292
ASP A 518
HIS A 612
TRP A 613
 None
ACR  A1015 (-3.1A)
None
ACR  A1015 (-4.8A)
 1.22A 1pk2A-5nn8A:
undetectable		 1pk2A-5nn8A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 11 VAL A 588
THR A 593
PRO A 365
ILE A 517
ALA A 610
 None
 1.12A 2admB-5nn8A:
undetectable		 2admB-5nn8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 SER A 135
PHE A 218
LEU A 169
LEU A 232
 None
 0.83A 2bfpD-5nn8A:
undetectable		 2bfpD-5nn8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.43A 2c7vC-5nn8A:
undetectable		 2c7vC-5nn8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_D_MTXD1272_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 10 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.43A 2c7vD-5nn8A:
1.2		 2c7vD-5nn8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 VAL A 740
LEU A 745
PHE A 767
THR A 753
 EDO  A1023 (-3.6A)
None
None
None
 1.14A 2f78A-5nn8A:
undetectable		 2f78A-5nn8A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 VAL A 740
LEU A 745
PHE A 767
THR A 753
 EDO  A1023 (-3.6A)
None
None
None
 1.12A 2f78B-5nn8A:
undetectable		 2f78B-5nn8A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 ARG A 527
THR A 551
THR A 333
ASP A 243
 None
 1.13A 2okcB-5nn8A:
undetectable		 2okcB-5nn8A:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ASP A 404
ILE A 441
TRP A 481
ASP A 518
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.25A 2qmjA-5nn8A:
51.4		 2qmjA-5nn8A:
44.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 11 LEU A 239
LEU A 232
VAL A 220
LEU A 167
VAL A 171
 None
 1.08A 2uxoB-5nn8A:
undetectable		 2uxoB-5nn8A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 282
ASP A 404
ASP A 518
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.54A 2x2iA-5nn8A:
37.0		 2x2iA-5nn8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 TRP A 516
MET A 519
ARG A 600
TRP A 613
 None
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
 0.44A 2x2iA-5nn8A:
37.0		 2x2iA-5nn8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.62A 2x2iB-5nn8A:
32.3		 2x2iB-5nn8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.53A 2x2iC-5nn8A:
36.9		 2x2iC-5nn8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.57A 2x2iD-5nn8A:
32.2		 2x2iD-5nn8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.37A 2x9gA-5nn8A:
undetectable		 2x9gA-5nn8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.39A 2x9gB-5nn8A:
1.5		 2x9gB-5nn8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.37A 2x9gC-5nn8A:
undetectable		 2x9gC-5nn8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 PHE A 240
PRO A  94
ASP A 163
PHE A 159
PRO A 238
 None
 1.37A 2x9gD-5nn8A:
1.4		 2x9gD-5nn8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 THR A 711
PHE A 878
MET A 943
ILE A 824
HIS A 708
 None
 1.40A 2ydoA-5nn8A:
undetectable		 2ydoA-5nn8A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TYR A 685
MET A 391
THR A 392
LEU A 398
 NAG  A1007 (-4.2A)
None
None
None
 1.15A 3ag2J-5nn8A:
undetectable		 3ag2J-5nn8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 ASP A 645
ILE A 598
VAL A 400
THR A 384
 None
 1.08A 3eigA-5nn8A:
undetectable		 3eigA-5nn8A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ALA A 853
ILE A 885
VAL A 886
ILE A 877
PRO A 825
 None
 0.81A 3ekwB-5nn8A:
undetectable		 3ekwB-5nn8A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 4 PRO A 285
THR A 286
GLY A 549
THR A 551
 None
 1.01A 3ib1A-5nn8A:
undetectable		 3ib1A-5nn8A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 GLU A 795
TYR A 773
PHE A 767
SER A 800
 None
 0.86A 3jz0B-5nn8A:
undetectable		 3jz0B-5nn8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 SER A 599
ARG A 608
GLY A 605
GLU A 196
 None
 1.04A 3k9fA-5nn8A:
undetectable
3k9fB-5nn8A:
undetectable
3k9fD-5nn8A:
undetectable		 3k9fA-5nn8A:
18.22
3k9fB-5nn8A:
18.22
3k9fD-5nn8A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 404
ILE A 441
TRP A 481
TRP A 516
ASP A 518
MET A 519
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.50A 3l4wA-5nn8A:
51.1		 3l4wA-5nn8A:
44.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 PHE A 240
PHE A 129
TYR A 133
THR A 158
 None
 1.23A 3lb3A-5nn8A:
undetectable		 3lb3A-5nn8A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 PHE A 240
PHE A 129
TYR A 133
THR A 158
 None
 1.18A 3lb3B-5nn8A:
0.0		 3lb3B-5nn8A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 GLY A 514
TRP A 402
VAL A 400
 None
 0.60A 3n62B-5nn8A:
undetectable		 3n62B-5nn8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 GLY A 514
TRP A 402
VAL A 400
 None
 0.62A 3n65B-5nn8A:
undetectable		 3n65B-5nn8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 GLY A 514
TRP A 402
VAL A 400
 None
 0.58A 3n66B-5nn8A:
undetectable		 3n66B-5nn8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 PHE A 667
ILE A 823
LEU A 826
THR A 777
 None
 1.22A 3nxuA-5nn8A:
undetectable		 3nxuA-5nn8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 9 PHE A 767
SER A 800
GLY A 770
ARG A 819
LEU A 751
 None
 1.48A 3pcqA-5nn8A:
undetectable		 3pcqA-5nn8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 282
ASP A 404
ILE A 441
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.40A 3phaA-5nn8A:
36.1		 3phaA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
ASP A 404
ILE A 441
TRP A 481
ASP A 518
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.40A 3phaA-5nn8A:
36.1		 3phaA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 282
ASP A 404
ILE A 441
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.38A 3phaB-5nn8A:
44.0		 3phaB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ASP A 404
ILE A 441
TRP A 481
ASP A 518
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.43A 3phaB-5nn8A:
44.0		 3phaB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 282
ASP A 404
ILE A 441
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.34A 3phaC-5nn8A:
42.8		 3phaC-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ASP A 404
TRP A 481
ASP A 518
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.35A 3phaC-5nn8A:
42.8		 3phaC-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 282
ASP A 404
ILE A 441
MET A 519
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.42A 3phaD-5nn8A:
42.9		 3phaD-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ASP A 404
TRP A 481
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.35A 3phaD-5nn8A:
42.9		 3phaD-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.47A 3pocA-5nn8A:
42.7		 3pocA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 481
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.67A 3pocA-5nn8A:
42.7		 3pocA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.02A 3pocA-5nn8A:
42.7		 3pocA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.49A 3pocB-5nn8A:
45.4		 3pocB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 481
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.62A 3pocB-5nn8A:
45.4		 3pocB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.03A 3pocB-5nn8A:
45.4		 3pocB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 VAL A 211
THR A 234
THR A 235
LEU A 169
VAL A 171
 None
None
NAG  A1004 ( 4.2A)
None
None
 0.85A 3sp9B-5nn8A:
undetectable		 3sp9B-5nn8A:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
ASP A 404
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.43A 3topA-5nn8A:
48.4		 3topA-5nn8A:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 PRO A 285
ASP A 404
ILE A 441
ASP A 518
PHE A 649
HIS A 674
 None
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.28A 3topA-5nn8A:
48.4		 3topA-5nn8A:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
ASP A 404
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.43A 3topB-5nn8A:
48.4		 3topB-5nn8A:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.90A 3u5kA-5nn8A:
undetectable		 3u5kA-5nn8A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.91A 3u5kB-5nn8A:
undetectable		 3u5kB-5nn8A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.93A 3u5kC-5nn8A:
undetectable		 3u5kC-5nn8A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.81A 3u5kD-5nn8A:
undetectable		 3u5kD-5nn8A:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		11 / 12 ASP A 282
ALA A 284
ASP A 404
ILE A 441
TRP A 516
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.29A 3w37A-5nn8A:
47.7		 3w37A-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
ALA A 284
ASP A 404
ILE A 441
TRP A 516
ASP A 518
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.29A 3welA-5nn8A:
47.9		 3welA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 TRP A 376
TRP A 481
MET A 519
TRP A 613
 ACR  A1015 ( 4.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
 0.66A 3welA-5nn8A:
47.9		 3welA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ALA A 284
ASP A 404
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.30A 3wemA-5nn8A:
47.3		 3wemA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 ASP A 282
ALA A 284
ASP A 404
ILE A 441
MET A 519
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.45A 3wemA-5nn8A:
47.3		 3wemA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TRP A 376
TRP A 481
TRP A 516
TRP A 613
 ACR  A1015 ( 4.6A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.8A)
 0.86A 3wemA-5nn8A:
47.3		 3wemA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 12 ASP A 282
ALA A 284
ASP A 404
ILE A 441
MET A 519
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.46A 3wenA-5nn8A:
47.4		 3wenA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
ALA A 284
ASP A 404
TRP A 516
ASP A 518
MET A 519
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.33A 3wenA-5nn8A:
47.4		 3wenA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 282
ALA A 284
ASP A 404
ILE A 441
ASP A 616
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.41A 3weoA-5nn8A:
53.3		 3weoA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ALA A 284
ASP A 404
TRP A 516
ASP A 518
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.28A 3weoA-5nn8A:
53.3		 3weoA-5nn8A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 6 TRP A 376
ILE A 441
TRP A 481
MET A 519
TRP A 613
 ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
 0.72A 3weoA-5nn8A:
53.3		 3weoA-5nn8A:
37.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.90A 4a9jA-5nn8A:
undetectable		 4a9jA-5nn8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.82A 4a9jB-5nn8A:
undetectable		 4a9jB-5nn8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 VAL A 939
LEU A 941
LEU A 901
ILE A 885
 CSO  A 938 ( 2.8A)
None
None
None
 0.85A 4a9jC-5nn8A:
undetectable		 4a9jC-5nn8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		8 / 12 ASP A 404
LEU A 405
ILE A 441
ASP A 518
ARG A 600
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.61A 4b9zA-5nn8A:
37.4		 4b9zA-5nn8A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 611
TYR A 354
LEU A 355
HIS A 295
LEU A 577
 None
 1.17A 4emaA-5nn8A:
undetectable		 4emaA-5nn8A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 518
ASP A 282
ASP A 645
GLU A 262
HIS A 612
 ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
None
 1.37A 4feuA-5nn8A:
2.5
4feuB-5nn8A:
2.0		 4feuA-5nn8A:
14.51
4feuB-5nn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 11 HIS A 612
ASP A 518
ASP A 282
ASP A 645
GLU A 262
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
 1.46A 4fevE-5nn8A:
undetectable		 4fevE-5nn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 PHE A 490
TYR A 575
ILE A 557
PRO A 488
 None
 1.17A 4g5jA-5nn8A:
undetectable		 4g5jA-5nn8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 10 HIS A 612
ASP A 518
ASP A 282
ASP A 645
GLU A 262
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
 1.42A 4gkhG-5nn8A:
2.0
4gkhH-5nn8A:
undetectable		 4gkhG-5nn8A:
14.51
4gkhH-5nn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 10 HIS A 612
ASP A 518
ASP A 282
ASP A 645
GLU A 262
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
 1.41A 4gkhK-5nn8A:
1.9
4gkhL-5nn8A:
0.7		 4gkhK-5nn8A:
14.51
4gkhL-5nn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 11 HIS A 612
ASP A 518
ASP A 282
ASP A 645
GLU A 262
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
 1.43A 4gkiC-5nn8A:
undetectable
4gkiD-5nn8A:
undetectable		 4gkiC-5nn8A:
14.51
4gkiD-5nn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 PRO A 808
ASN A 815
HIS A 817
 None
 1.03A 4ma3H-5nn8A:
undetectable
4ma3L-5nn8A:
undetectable		 4ma3H-5nn8A:
14.00
4ma3L-5nn8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 638
GLY A 607
THR A 578
GLY A 359
VAL A 358
 None
 0.93A 4o33A-5nn8A:
undetectable		 4o33A-5nn8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 638
GLY A 607
THR A 578
GLY A 359
VAL A 358
 None
 0.96A 4o3fA-5nn8A:
undetectable		 4o3fA-5nn8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 ARG A 837
THR A 834
ASP A 399
TYR A 703
 None
GOL  A1038 (-3.3A)
None
None
 1.48A 4oltB-5nn8A:
undetectable		 4oltB-5nn8A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 ARG A 837
THR A 834
ASP A 399
TYR A 703
 None
GOL  A1038 (-3.3A)
None
None
 1.49A 4qwpA-5nn8A:
undetectable		 4qwpA-5nn8A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 259
ALA A 261
PHE A 311
ALA A 604
VAL A 358
 None
 1.21A 4ryaA-5nn8A:
undetectable		 4ryaA-5nn8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 VAL A 310
LEU A 248
VAL A 220
THR A 234
 None
 1.00A 5e4dA-5nn8A:
undetectable
5e4dB-5nn8A:
undetectable		 5e4dA-5nn8A:
13.48
5e4dB-5nn8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 ILE A 517
HIS A 584
LEU A 587
ALA A 586
 None
 0.92A 5hrqE-5nn8A:
undetectable
5hrqF-5nn8A:
undetectable
5hrqJ-5nn8A:
undetectable		 5hrqE-5nn8A:
3.47
5hrqF-5nn8A:
2.97
5hrqJ-5nn8A:
2.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 516
ASP A 518
MET A 519
PHE A 525
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
None
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.58A 5iefA-5nn8A:
50.0		 5iefA-5nn8A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 4 ARG A 600
TRP A 613
ASP A 645
ARG A 672
 ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
None
ACR  A1015 ( 4.8A)
 0.18A 5iefA-5nn8A:
50.0		 5iefA-5nn8A:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 598
GLY A 611
ASP A 645
SER A 627
ILE A 631
 None
 1.21A 5igwA-5nn8A:
undetectable		 5igwA-5nn8A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 9 PHE A 767
SER A 800
GLY A 770
ARG A 819
LEU A 751
 None
 1.45A 5l8rA-5nn8A:
undetectable		 5l8rA-5nn8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 TYR A 766
PHE A 731
THR A 737
GLY A 765
 None
None
None
EDO  A1023 ( 4.5A)
 1.05A 5mraA-5nn8A:
undetectable
5mraB-5nn8A:
undetectable		 5mraA-5nn8A:
10.93
5mraB-5nn8A:
10.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 4 HIS A 432
GLY A 435
ARG A 437
THR A 834
 GOL  A1038 (-3.6A)
GOL  A1038 ( 4.0A)
GOL  A1038 (-3.5A)
GOL  A1038 (-3.3A)
 0.13A 5nn4A-5nn8A:
66.7		 5nn4A-5nn8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		12 / 12 TRP A 376
ASP A 404
LEU A 405
ILE A 441
TRP A 481
TRP A 516
ASP A 518
MET A 519
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.63A 5nn6A-5nn8A:
60.6		 5nn6A-5nn8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 LEU A 587
VAL A 597
TRP A 499
ALA A 610
GLY A 611
 None
 0.94A 5tzoB-5nn8A:
undetectable		 5tzoB-5nn8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 GLY A 147
ARG A 168
VAL A 171
ASP A 170
 None
None
None
EDO  A1029 (-3.5A)
 0.91A 5vlmA-5nn8A:
undetectable		 5vlmA-5nn8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 ILE A 446
TYR A 575
TRP A 499
VAL A 442
 None
 0.98A 5vlmF-5nn8A:
undetectable		 5vlmF-5nn8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 GLY A 514
TRP A 402
VAL A 400
 None
 0.60A 5vuoB-5nn8A:
undetectable		 5vuoB-5nn8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TYR A 685
MET A 391
THR A 392
LEU A 398
 NAG  A1007 (-4.2A)
None
None
None
 1.13A 5wauJ-5nn8A:
undetectable		 5wauJ-5nn8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TYR A 685
MET A 391
THR A 392
LEU A 398
 NAG  A1007 (-4.2A)
None
None
None
 1.12A 5x19J-5nn8A:
undetectable		 5x19J-5nn8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TYR A 685
MET A 391
THR A 392
LEU A 398
 NAG  A1007 (-4.2A)
None
None
None
 1.17A 5x1bW-5nn8A:
undetectable		 5x1bW-5nn8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 TYR A 685
MET A 391
THR A 392
LEU A 398
 NAG  A1007 (-4.2A)
None
None
None
 1.14A 5x1fW-5nn8A:
undetectable		 5x1fW-5nn8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		7 / 10 TRP A 516
ASP A 518
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.43A 5x7pA-5nn8A:
33.0		 5x7pA-5nn8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 10 PHE A 767
SER A 800
GLY A 770
ARG A 819
LEU A 751
 None
 1.47A 5zjiA-5nn8A:
undetectable
5zjiJ-5nn8A:
undetectable		 5zjiA-5nn8A:
6.65
5zjiJ-5nn8A:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 GLN A 553
VAL A 547
LEU A 476
PRO A 522
 None
 1.29A 6brdB-5nn8A:
undetectable		 6brdB-5nn8A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 282
ILE A 441
MET A 519
ARG A 600
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.3A)
 1.05A 6c9xA-5nn8A:
36.2		 6c9xA-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
TRP A 376
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.69A 6c9xA-5nn8A:
36.2		 6c9xA-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 TRP A 376
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.06A 6c9xA-5nn8A:
36.2		 6c9xA-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 282
ILE A 441
MET A 519
ARG A 600
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.3A)
 1.06A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 282
TRP A 376
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.70A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 TRP A 376
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.06A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 0.86A 6c9zA-5nn8A:
34.9		 6c9zA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.35A 6c9zA-5nn8A:
34.9		 6c9zA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.99A 6c9zA-5nn8A:
34.9		 6c9zA-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 282
ILE A 441
MET A 519
ARG A 600
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.3A)
 1.00A 6c9zB-5nn8A:
36.1		 6c9zB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 282
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.41A 6c9zB-5nn8A:
36.1		 6c9zB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.98A 6c9zB-5nn8A:
36.1		 6c9zB-5nn8A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.45A 6ca1A-5nn8A:
42.7		 6ca1A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 TRP A 376
ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.69A 6ca1A-5nn8A:
42.7		 6ca1A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.97A 6ca1A-5nn8A:
42.7		 6ca1A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.47A 6ca1B-5nn8A:
41.7		 6ca1B-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 TRP A 376
ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.64A 6ca1B-5nn8A:
41.7		 6ca1B-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 TRP A 376
ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.96A 6ca1B-5nn8A:
41.7		 6ca1B-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		9 / 12 ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.41A 6ca3A-5nn8A:
36.2		 6ca3A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.44A 6ca3A-5nn8A:
36.2		 6ca3A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.89A 6ca3A-5nn8A:
36.2		 6ca3A-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
 1.44A 6ca3B-5nn8A:
34.9		 6ca3B-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		10 / 12 ASP A 404
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.61A 6ca3B-5nn8A:
34.9		 6ca3B-5nn8A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens) 		6 / 12 ASP A 404
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.20A 6ca3B-5nn8A:
34.9		 6ca3B-5nn8A:
8.49