SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 THR A  72
PRO A 248
THR A  70
 None
 0.88A 1dscC-5nnbA:
undetectable		 1dscC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 THR A  70
THR A  72
PRO A 248
 None
 0.88A 1fjaC-5nnbA:
undetectable		 1fjaC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 THR A  70
THR A  72
PRO A 248
 None
 0.88A 1fjaD-5nnbA:
undetectable		 1fjaD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 7 SER A 165
THR A 189
VAL A 190
ALA A 206
 None
 0.98A 1fo4B-5nnbA:
undetectable		 1fo4B-5nnbA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 11 ASP A 117
SER A 165
ASN A 157
ARG A 159
GLY A 197
 None
 1.49A 1jr1A-5nnbA:
undetectable		 1jr1A-5nnbA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 10 GLY A 217
LEU A 249
TYR A 216
THR A 187
GLY A 186
 None
 1.47A 1kvlA-5nnbA:
undetectable		 1kvlA-5nnbA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 ILE A 235
LEU A  11
VAL A   8
LEU A   7
 None
 0.82A 2w98B-5nnbA:
undetectable		 2w98B-5nnbA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  79
ILE A  32
HIS A 207
ASP A  75
 92K  A 302 (-3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-4.0A)
MN  A 301 ( 1.8A)
 1.11A 2xadA-5nnbA:
undetectable		 2xadA-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  69
ILE A  32
HIS A  79
ASP A  75
 MN  A 301 ( 3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-3.2A)
MN  A 301 ( 1.8A)
 1.05A 2xadB-5nnbA:
undetectable		 2xadB-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  79
ILE A  32
HIS A 207
ASP A  75
 92K  A 302 (-3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-4.0A)
MN  A 301 ( 1.8A)
 1.11A 2xadC-5nnbA:
undetectable		 2xadC-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 THR A  72
PRO A 248
THR A  70
 None
 0.78A 316dC-5nnbA:
undetectable		 316dC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 12 ASP A  92
SER A  78
PHE A  99
SER A 247
HIS A  69
 None
None
None
None
MN  A 301 ( 3.2A)
 1.18A 3d91A-5nnbA:
undetectable		 3d91A-5nnbA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 5 PRO A  35
THR A 189
VAL A 190
GLY A 191
 None
None
None
92K  A 302 ( 4.3A)
 1.08A 3elzA-5nnbA:
undetectable		 3elzA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 12 CYH A 108
THR A 145
THR A 189
ILE A 125
ILE A 124
 None
 1.35A 3gwxA-5nnbA:
undetectable		 3gwxA-5nnbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 4 LEU A 221
MET A 254
ILE A  94
ASP A 138
 None
 1.42A 3hecA-5nnbA:
undetectable		 3hecA-5nnbA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 12 ALA A 206
LEU A 176
HIS A 211
ALA A 236
LEU A 221
 None
 1.33A 3tm4A-5nnbA:
undetectable		 3tm4A-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 12 ALA A 206
LEU A 176
HIS A 211
ALA A 236
LEU A 221
 None
 1.32A 3tm4B-5nnbA:
undetectable		 3tm4B-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 11 VAL A 251
ALA A 236
GLY A  71
SER A 247
ASP A  20
 None
 1.28A 4mm9A-5nnbA:
undetectable		 4mm9A-5nnbA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 GLN A 196
HIS A 164
ARG A 159
 None
 0.69A 4qyqA-5nnbA:
undetectable		 4qyqA-5nnbA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		3 / 3 GLN A 196
HIS A 164
ARG A 159
 None
 0.65A 4qyqB-5nnbA:
undetectable		 4qyqB-5nnbA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 GLN A 196
ASP A 117
HIS A 164
ARG A 159
 None
 1.14A 4qyqC-5nnbA:
undetectable		 4qyqC-5nnbA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		5 / 9 LEU A 176
ARG A 180
LEU A 120
ILE A 106
ALA A 126
 None
 1.23A 4z69A-5nnbA:
undetectable		 4z69A-5nnbA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 5 GLY A 162
ASP A 161
ARG A 159
MET A 143
 None
 1.46A 5gwkA-5nnbA:
undetectable		 5gwkA-5nnbA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 GLN A 196
ASP A 117
HIS A 164
ARG A 159
 None
 1.14A 5hpwC-5nnbA:
undetectable		 5hpwC-5nnbA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.63A 5ncdA-5nnbA:
undetectable
5ncdD-5nnbA:
undetectable		 5ncdA-5nnbA:
undetectable
5ncdD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.61A 5ncdB-5nnbA:
undetectable
5ncdC-5nnbA:
undetectable		 5ncdB-5nnbA:
undetectable
5ncdC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.77A 5nekB-5nnbA:
undetectable		 5nekB-5nnbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.69A 5nekD-5nnbA:
undetectable		 5nekD-5nnbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.70A 5nelA-5nnbA:
undetectable
5nelD-5nnbA:
undetectable		 5nelA-5nnbA:
undetectable
5nelD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.29A 5nnaA-5nnbA:
43.5		 5nnaA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.43A 5nnaA-5nnbA:
43.5		 5nnaA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.32A 5nnaB-5nnbA:
43.8		 5nnaB-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.40A 5nnaB-5nnbA:
43.8		 5nnaB-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.33A 5nnaC-5nnbA:
43.4		 5nnaC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.42A 5nnaC-5nnbA:
43.4		 5nnaC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.28A 5nnaD-5nnbA:
42.9		 5nnaD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.46A 5nnaD-5nnbA:
42.9		 5nnaD-5nnbA:
undetectable