SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 5 LEU A1824
GLY A1842
PRO A1811
VAL A1810
 None
 0.90A 2aojA-5nnlA:
undetectable		 2aojA-5nnlA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 5 ASP A1696
SER A1672
LEU A1739
GLY A1737
 None
 1.05A 2j2pA-5nnlA:
undetectable
2j2pB-5nnlA:
undetectable		 2j2pA-5nnlA:
18.87
2j2pB-5nnlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 6 ASP A1696
SER A1672
LEU A1739
GLY A1737
 None
 1.01A 2j2pA-5nnlA:
undetectable
2j2pC-5nnlA:
undetectable		 2j2pA-5nnlA:
18.87
2j2pC-5nnlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 6 ASP A1696
SER A1672
LEU A1739
GLY A1737
 None
 1.04A 2j2pD-5nnlA:
undetectable
2j2pF-5nnlA:
undetectable		 2j2pD-5nnlA:
18.87
2j2pF-5nnlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ILE A1647
ALA A1532
GLY A1737
SER A1552
ARG A1547
 None
 1.05A 2okcA-5nnlA:
undetectable		 2okcA-5nnlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ILE A1647
ALA A1532
GLY A1737
SER A1552
ARG A1547
 None
 1.04A 2okcB-5nnlA:
undetectable		 2okcB-5nnlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ALA A1767
VAL A1778
ILE A1522
LEU A1524
PRO A1525
 None
 1.23A 2qk8A-5nnlA:
undetectable		 2qk8A-5nnlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ALA A1767
VAL A1778
LYS A1779
ILE A1802
LEU A1524
 None
 1.21A 2qk8A-5nnlA:
undetectable		 2qk8A-5nnlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		3 / 3 LEU A1702
VAL A1768
ARG A1772
 None
 0.86A 3b0wB-5nnlA:
undetectable		 3b0wB-5nnlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 PHE A1790
ILE A1530
VAL A1633
LEU A1661
ILE A1618
 None
 1.28A 3em0B-5nnlA:
undetectable		 3em0B-5nnlA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 8 ALA A1531
ILE A1530
ASN A1529
PRO A1786
 None
 0.91A 3fxrA-5nnlA:
undetectable		 3fxrA-5nnlA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ASP A1696
ALA A1531
ASN A1529
ILE A1658
PHE A1617
 None
 1.14A 3w37A-5nnlA:
undetectable		 3w37A-5nnlA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ASP A1696
ALA A1531
ASN A1529
ILE A1658
PHE A1617
 None
 1.13A 3welA-5nnlA:
5.9		 3welA-5nnlA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 5 SER A1566
LYS A1567
LEU A1537
ASP A1544
 None
 1.17A 4ifxA-5nnlA:
undetectable		 4ifxA-5nnlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 5 SER A1566
LYS A1567
LEU A1537
ASP A1544
 None
 1.16A 4ig1A-5nnlA:
undetectable		 4ig1A-5nnlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 5 SER A1566
LYS A1567
LEU A1537
ASP A1544
 None
 1.16A 4xdtA-5nnlA:
undetectable		 4xdtA-5nnlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 12 TYR A1557
ILE A1736
PRO A1740
VAL A1810
LEU A1824
 None
 1.18A 5ienA-5nnlA:
undetectable		 5ienA-5nnlA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 10 TYR A1557
ILE A1736
PRO A1740
VAL A1810
LEU A1824
 None
 1.17A 5ienB-5nnlA:
undetectable		 5ienB-5nnlA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 6 ILE A1562
VAL A1548
VAL A1534
SER A1552
 None
 0.99A 5jwaH-5nnlA:
2.3		 5jwaH-5nnlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		4 / 8 THR A1549
ASP A1759
VAL A1828
GLY A1842
 None
 0.96A 5nzyA-5nnlA:
undetectable		 5nzyA-5nnlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 11 ALA A1758
SER A1552
ILE A1528
ASN A1529
GLN A1795
 None
 1.25A 5y80A-5nnlA:
undetectable		 5y80A-5nnlA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 9 VAL A1588
ARG A1586
ALA A1580
VAL A1579
SER A1576
 None
 1.45A 6c2mA-5nnlA:
undetectable		 6c2mA-5nnlA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN
(Chaetomium
thermophilum) 		5 / 9 VAL A1548
LEU A1594
ALA A1580
VAL A1579
SER A1576
 None
 1.28A 6c2mB-5nnlA:
undetectable		 6c2mB-5nnlA:
11.70