SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 LEU A  49
PRO A   9
ILE A 134
LEU A 131
 None
 1.09A 1ya4B-5nnoA:
0.6		 1ya4B-5nnoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 LEU A  49
PRO A   9
ILE A 134
LEU A 131
 None
 1.09A 1ya4C-5nnoA:
undetectable		 1ya4C-5nnoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 TRP A 249
THR A 258
TYR A 129
 None
92N  A 602 (-3.8A)
92N  A 602 (-4.0A)
 1.25A 2a3aA-5nnoA:
undetectable		 2a3aA-5nnoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 TRP A 249
THR A 258
TYR A 129
 None
92N  A 602 (-3.8A)
92N  A 602 (-4.0A)
 1.29A 2a3bA-5nnoA:
undetectable		 2a3bA-5nnoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 PHE A 291
GLY A 288
PRO A 349
GLY A 338
 None
 0.89A 2y6rB-5nnoA:
2.0		 2y6rB-5nnoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 PHE A 291
LEU A 292
GLU A 339
ARG A 283
ALA A 255
 None
 1.19A 3apvA-5nnoA:
undetectable		 3apvA-5nnoA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 PHE A 291
LEU A 292
GLU A 339
ARG A 283
ALA A 255
 None
 1.35A 3apvB-5nnoA:
undetectable		 3apvB-5nnoA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 PHE A 291
LEU A 292
GLU A 339
ARG A 283
ALA A 255
 None
 1.46A 3apwB-5nnoA:
undetectable		 3apwB-5nnoA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 TYR A 444
GLN A 136
ILE A  77
LEU A  80
 None
 1.08A 3ls4L-5nnoA:
undetectable		 3ls4L-5nnoA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 GLY A 435
GLY A 437
ALA A 416
LEU A 222
LEU A 393
 None
None
None
None
NAD  A 601 (-4.3A)
 1.15A 3mteA-5nnoA:
4.4		 3mteA-5nnoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ALA A 416
ILE A 260
ASN A 128
GLY A 225
TYR A 199
 None
92N  A 602 ( 4.7A)
NAD  A 601 ( 3.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.9A)
 1.16A 3nrrA-5nnoA:
undetectable		 3nrrA-5nnoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 ILE A  61
ASP A  70
GLU A  76
VAL A  50
 None
 1.16A 4nkxC-5nnoA:
undetectable		 4nkxC-5nnoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 ILE A  61
ASP A  70
GLU A  76
VAL A  50
 None
 1.13A 4nkxD-5nnoA:
undetectable		 4nkxD-5nnoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 ALA A 426
ASP A 263
GLY A 415
SER A 259
GLY A 226
 92N  A 602 (-3.6A)
None
None
NAD  A 601 ( 3.1A)
None
 1.29A 4xp4A-5nnoA:
undetectable		 4xp4A-5nnoA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 ALA A 426
ASP A 263
GLY A 435
SER A 259
GLY A 226
 92N  A 602 (-3.6A)
None
None
NAD  A 601 ( 3.1A)
None
 1.04A 4xp4A-5nnoA:
undetectable		 4xp4A-5nnoA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5nno ALDEHYDE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 9 LEU A 393
VAL A 423
ILE A 253
GLY A 256
ILE A 260
 NAD  A 601 (-4.3A)
None
None
None
92N  A 602 ( 4.7A)
 1.09A 5kqxB-5nnoA:
undetectable		 5kqxB-5nnoA:
11.09