SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ALA A 447
ALA A 460
LYS A 459
GLU A 456
 None
 0.98A 1e7cA-5nnpA:
undetectable		 1e7cA-5nnpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A  61
ALA A  66
SER A  47
 None
 0.57A 1errB-5nnpA:
undetectable		 1errB-5nnpA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 480
PHE A 660
ALA A 562
ALA A 558
HIS A 510
 None
 1.13A 1hbpA-5nnpA:
undetectable		 1hbpA-5nnpA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 480
PHE A 660
ALA A 562
ALA A 558
HIS A 510
 None
 1.05A 1kt5A-5nnpA:
undetectable		 1kt5A-5nnpA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 655
ASP A 656
TYR A 509
ALA A 505
GLN A 497
 None
 1.32A 1oltA-5nnpA:
undetectable		 1oltA-5nnpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU B 131
ALA B 127
VAL B 121
TYR B 132
ILE B  96
 None
None
None
None
GOL  B 201 (-4.8A)
 1.09A 1s9pA-5nnpB:
undetectable		 1s9pA-5nnpB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU B 131
ALA B 127
VAL B 121
TYR B 132
ILE B  96
 None
None
None
None
GOL  B 201 (-4.8A)
 1.13A 1s9pD-5nnpB:
undetectable		 1s9pD-5nnpB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 LEU C  96
LEU C  98
SER C  99
VAL C  84
 None
 0.97A 1tyrB-5nnpC:
undetectable		 1tyrB-5nnpC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP B 160
TYR B 116
GLU B 141
 None
 0.78A 1vm1A-5nnpB:
undetectable		 1vm1A-5nnpB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 231
SER A 232
TYR A 230
LEU A 207
 None
 1.19A 1xz1A-5nnpA:
2.8		 1xz1A-5nnpA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 231
SER A 232
TYR A 230
LEU A 207
 None
 1.19A 1xz3A-5nnpA:
2.8		 1xz3A-5nnpA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 240
ALA A 241
LEU A 261
ILE A 262
ALA A 228
 None
 0.95A 2aclG-5nnpA:
undetectable		 2aclG-5nnpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 201
ASP A 202
ALA A 198
TYR A 230
ARG A 205
 None
None
None
None
GOL  A 804 (-3.9A)
 1.36A 2avdB-5nnpA:
undetectable		 2avdB-5nnpA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 437
ASP A 408
ASN A 444
 None
 0.68A 2bm9D-5nnpA:
undetectable		 2bm9D-5nnpA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 305
ALA A 309
LEU A 341
ASP A 290
 None
None
None
GOL  B 201 (-4.3A)
 0.98A 2bxkA-5nnpA:
undetectable		 2bxkA-5nnpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 531
LEU B  36
ALA A 538
LEU A 157
THR A 149
 None
None
GOL  A 801 (-3.2A)
None
None
 1.35A 2oaxB-5nnpA:
undetectable		 2oaxB-5nnpA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY B  80
LEU B 119
LEU B 159
SER B  42
SER B 104
 None
 1.04A 3g2oB-5nnpB:
2.6		 3g2oB-5nnpB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ILE A 672
ALA A 698
TYR A 682
ILE A 734
ILE A 718
 None
 1.05A 3prsA-5nnpA:
undetectable		 3prsA-5nnpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ILE A 672
ALA A 698
TYR A 682
LEU A 665
ILE A 734
 None
 0.98A 3prsA-5nnpA:
undetectable		 3prsA-5nnpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 VAL B  46
ALA B  45
GLY B  63
TYR B  64
HIS A 254
 None
 1.19A 3qxyA-5nnpB:
undetectable		 3qxyA-5nnpB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 VAL B  46
ALA B  45
GLY B  63
TYR B  64
HIS A 254
 None
 1.19A 3rc0B-5nnpB:
undetectable		 3rc0B-5nnpB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR A 566
LEU A 647
ALA A 649
ASP A 641
 None
 1.16A 3rodD-5nnpA:
undetectable		 3rodD-5nnpA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLN A 132
GLN A 121
LEU A 138
ALA A 154
TYR A 155
 None
 1.22A 3sxjA-5nnpA:
undetectable		 3sxjA-5nnpA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLN A 132
GLN A 121
LEU A 138
ALA A 154
TYR A 155
 None
 1.22A 3sxjB-5nnpA:
undetectable		 3sxjB-5nnpA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 138
ILE A 536
TYR A 130
TYR A 171
 None
 1.00A 3vt7A-5nnpA:
undetectable		 3vt7A-5nnpA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 LYS A 242
ARG A 245
LEU A 248
ASP A 249
 None
 1.49A 4ig1A-5nnpA:
undetectable		 4ig1A-5nnpA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 GLU B 178
ARG A 227
VAL A 223
CYH A 217
LEU A 218
 None
 1.49A 4k36B-5nnpB:
undetectable		 4k36B-5nnpB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TYR A 555
GLN A 666
TRP A 545
 None
GOL  A 811 (-4.2A)
None
 1.06A 4kn2C-5nnpA:
undetectable		 4kn2C-5nnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ILE A 515
SER A 514
ASP A 522
ASP A 525
 None
 1.39A 4krhB-5nnpA:
undetectable		 4krhB-5nnpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ARG B  92
ASN B 125
ALA B 127
LEU B 131
TYR B 132
 None
 0.75A 4oadA-5nnpB:
15.6		 4oadA-5nnpB:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ARG B  92
ALA B  97
ASN B 125
ALA B 127
LEU B 131
 None
 0.87A 4oaeA-5nnpB:
15.5		 4oaeA-5nnpB:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY B  63
TYR B 132
LEU B 131
MET B 101
LEU B  22
 None
 1.34A 4xldA-5nnpB:
undetectable		 4xldA-5nnpB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TYR A 352
LYS A 366
LYS A 368
 None
 1.34A 5dbyA-5nnpA:
undetectable		 5dbyA-5nnpA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 8 LEU B 106
ALA A 246
VAL B 109
GLN B 167
 None
 1.00A 5nu7A-5nnpB:
undetectable		 5nu7A-5nnpB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 TYR B 132
VAL A 321
SER A 323
THR A 324
VAL B  87
 None
 1.37A 6a93B-5nnpB:
undetectable		 6a93B-5nnpB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 LEU A 221
GLU B 110
LEU B 106
HIS A 254
 None
 1.25A 6cbzA-5nnpA:
undetectable		 6cbzA-5nnpA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 527
ARG A 125
ILE A 122
 None
 0.70A 6fgdA-5nnpA:
undetectable		 6fgdA-5nnpA:
19.36