SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nny WIPB
(Legionella
pneumophila) 		6 / 12 ILE A 265
PHE A 246
LYS A 245
ILE A 278
LEU A 281
ILE A 214
 None
 1.44A 1rx7A-5nnyA:
undetectable		 1rx7A-5nnyA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 GLY A 235
HIS A 238
ASN A 237
ILE A 239
 None
 0.67A 1xf1B-5nnyA:
undetectable		 1xf1B-5nnyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5nny WIPB
(Legionella
pneumophila) 		4 / 5 ILE A 327
ILE A 214
ILE A 116
LEU A 258
 None
 0.93A 1zgyA-5nnyA:
undetectable		 1zgyA-5nnyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 PHE A 322
ILE A 226
VAL A 228
PHE A 326
 None
 0.79A 2cizA-5nnyA:
undetectable		 2cizA-5nnyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 4 SER A 149
GLY A 152
HIS A 179
ASP A  72
 None
 1.39A 2oxtC-5nnyA:
undetectable		 2oxtC-5nnyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5nny WIPB
(Legionella
pneumophila) 		5 / 12 ALA A 264
ARG A 244
PHE A 246
LEU A 281
THR A 261
 None
 1.13A 2w3bA-5nnyA:
undetectable		 2w3bA-5nnyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5nny WIPB
(Legionella
pneumophila) 		5 / 12 ILE A 104
ILE A  50
ILE A 106
ILE A 130
VAL A 207
 None
 1.09A 2ygoA-5nnyA:
undetectable		 2ygoA-5nnyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 ILE A 278
PHE A 246
HIS A 231
VAL A 228
 None
 1.10A 4a97I-5nnyA:
undetectable		 4a97I-5nnyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5nny WIPB
(Legionella
pneumophila) 		4 / 8 ASN A 181
ALA A 185
SER A 182
TYR A  64
 None
 0.75A 4ijiF-5nnyA:
undetectable		 4ijiF-5nnyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 8 ASN A 181
ARG A 123
ASP A 127
ILE A 130
 None
 1.06A 4k0bA-5nnyA:
undetectable		 4k0bA-5nnyA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.31A 4mi4A-5nnyA:
undetectable		 4mi4A-5nnyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 7 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.27A 4mi4A-5nnyA:
undetectable
4mi4C-5nnyA:
undetectable		 4mi4A-5nnyA:
20.55
4mi4C-5nnyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 7 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.32A 4mj8C-5nnyA:
undetectable		 4mj8C-5nnyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 ARG A 173
GLU A 154
TYR A 288
 None
 0.92A 4r29D-5nnyA:
undetectable		 4r29D-5nnyA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 7 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.10A 4r87I-5nnyA:
undetectable		 4r87I-5nnyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5nny WIPB
(Legionella
pneumophila) 		4 / 8 ILE A 146
LEU A  44
ILE A  49
LEU A 120
 None
 0.75A 5ieoA-5nnyA:
undetectable		 5ieoA-5nnyA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 VAL A 307
SER A 149
TRP A 308
 None
 0.97A 5jwaA-5nnyA:
undetectable		 5jwaA-5nnyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5nny WIPB
(Legionella
pneumophila) 		5 / 12 PHE A  81
SER A 182
PHE A 183
TYR A 128
ILE A 195
 None
 1.12A 5ljeA-5nnyA:
undetectable		 5ljeA-5nnyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 ASP A 118
ASP A 122
HIS A 151
HIS A  34
 None
 0.77A 5ncdA-5nnyA:
undetectable
5ncdD-5nnyA:
undetectable		 5ncdA-5nnyA:
24.22
5ncdD-5nnyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 ASP A 118
ASP A 122
HIS A 151
HIS A  34
 None
 0.79A 5ncdB-5nnyA:
undetectable
5ncdC-5nnyA:
undetectable		 5ncdB-5nnyA:
24.22
5ncdC-5nnyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 8 ASP A 118
ASP A 122
HIS A 151
HIS A  34
 None
 0.90A 5nekB-5nnyA:
undetectable		 5nekB-5nnyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 8 ASP A 118
ASP A 122
HIS A 151
HIS A  34
 None
 0.74A 5nekD-5nnyA:
undetectable		 5nekD-5nnyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 ASP A 118
ASP A 122
HIS A 151
HIS A  34
 None
 0.85A 5nelA-5nnyA:
undetectable
5nelD-5nnyA:
undetectable		 5nelA-5nnyA:
24.22
5nelD-5nnyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 HIS A  34
ASP A 122
HIS A 151
 None
 0.64A 5oexA-5nnyA:
undetectable		 5oexA-5nnyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 HIS A  34
ASP A 122
HIS A 151
 None
 0.58A 5oexB-5nnyA:
undetectable		 5oexB-5nnyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 HIS A  34
ASP A 122
HIS A 151
 None
 0.63A 5oexC-5nnyA:
undetectable		 5oexC-5nnyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 5nny WIPB
(Legionella
pneumophila) 		3 / 3 HIS A  34
ASP A 122
HIS A 151
 None
 0.63A 5oexD-5nnyA:
undetectable		 5oexD-5nnyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5nny WIPB
(Legionella
pneumophila) 		4 / 6 GLU A 119
LEU A 120
TYR A 208
SER A 149
 None
 0.99A 5phhA-5nnyA:
undetectable		 5phhA-5nnyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5nny WIPB
(Legionella
pneumophila) 		5 / 10 GLU A 119
GLY A 152
ILE A 146
HIS A 231
GLY A 117
 None
 0.97A 6e5zA-5nnyA:
undetectable		 6e5zA-5nnyA:
21.41