SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 12 ALA B 339
HIS B 359
LEU B 317
THR B 362
ALA B 327
 None
 1.10A 1bzfA-5nnzB:
undetectable		 1bzfA-5nnzB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 8 HIS B 241
THR B 242
ILE B 256
SER B 219
 None
 0.80A 1c9sU-5nnzB:
undetectable
1c9sV-5nnzB:
undetectable		 1c9sU-5nnzB:
11.55
1c9sV-5nnzB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 10 ASN B 143
SER B 103
GLY B 104
PHE B 142
ASN B 144
 None
 1.41A 1ho5B-5nnzB:
undetectable		 1ho5B-5nnzB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 11 SER B 352
PHE B 395
LEU B 383
VAL B 402
THR B 404
 None
 1.21A 1q23F-5nnzB:
undetectable		 1q23F-5nnzB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 7 ARG B 412
ILE B 413
LEU B 100
GLY B 104
 None
 0.72A 1rtsB-5nnzB:
undetectable		 1rtsB-5nnzB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 8 HIS B 260
ALA B 297
LEU B 277
THR B 278
 None
 0.84A 2it4A-5nnzB:
undetectable		 2it4A-5nnzB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 6 ALA B 201
ILE B 222
HIS B 218
VAL B 244
 None
 1.19A 3nneG-5nnzB:
undetectable		 3nneG-5nnzB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 12 THR B 320
SER B 309
PHE B 311
VAL B 296
CYH B 295
 None
 1.39A 3u9fJ-5nnzB:
undetectable
3u9fK-5nnzB:
undetectable		 3u9fJ-5nnzB:
18.94
3u9fK-5nnzB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 8 SER B 392
HIS B 386
ILE B 413
TRP B 414
 None
 1.33A 4ms4A-5nnzB:
undetectable		 4ms4A-5nnzB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 12 GLY B 363
ALA B 369
ASN B 354
SER B 352
ILE B 351
 None
 1.25A 4pb1A-5nnzB:
undetectable		 4pb1A-5nnzB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		5 / 12 THR B 320
ALA B 319
LEU B 317
LEU B 360
LEU B 361
 None
 1.24A 4xi3D-5nnzB:
undetectable		 4xi3D-5nnzB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 6 THR B 410
ARG B 412
ILE B 390
GLU B 389
 None
 1.23A 5uigA-5nnzB:
undetectable		 5uigA-5nnzB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 6 GLY B 237
SER B 265
THR B 278
VAL B 243
 None
 0.94A 5ysiA-5nnzB:
undetectable		 5ysiA-5nnzB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		4 / 6 GLY B 237
SER B 280
THR B 278
VAL B 243
 None
 1.05A 5ysiA-5nnzB:
undetectable		 5ysiA-5nnzB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens) 		6 / 12 ILE B 351
LEU B 360
ALA B 374
ILE B 306
CYH B 285
LEU B 277
 None
 1.46A 6a5yD-5nnzB:
undetectable		 6a5yD-5nnzB:
13.08