SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5no5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 10 THR A 238
ALA A 239
ALA A 215
LEU A 177
VAL A 180
 None
 1.23A 1claA-5no5A:
undetectable		 1claA-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5no5 ABYA5
(Verrucosispora) 		3 / 4 VAL A 104
TRP A 110
TRP A 132
 None
 0.95A 1gmkA-5no5A:
undetectable
1gmkB-5no5A:
undetectable		 1gmkA-5no5A:
undetectable
1gmkB-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 ASP A 200
LEU A 199
GLY A 196
PHE A 195
ALA A 203
 None
 1.28A 1hvyB-5no5A:
undetectable		 1hvyB-5no5A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 ALA A 223
GLY A 149
THR A 148
LEU A 284
LEU A 224
 None
 1.39A 1jipA-5no5A:
undetectable		 1jipA-5no5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 TYR A 187
ALA A 192
SER A 191
GLY A 149
SER A 219
 None
 1.02A 1kiaA-5no5A:
2.3		 1kiaA-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5no5 ABYA5
(Verrucosispora) 		4 / 8 GLY A 150
SER A 217
TYR A  30
HIS A 331
 None
 1.02A 1maaD-5no5A:
12.8		 1maaD-5no5A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 TYR A 187
ALA A 192
SER A 191
GLY A 149
SER A 219
 None
 1.09A 1nbiA-5no5A:
undetectable		 1nbiA-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 TYR A 187
ALA A 192
SER A 191
GLY A 149
SER A 219
 None
 1.10A 1nbiB-5no5A:
undetectable		 1nbiB-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 TYR A 187
ALA A 192
SER A 191
GLY A 149
SER A 219
 None
 1.11A 1nbiC-5no5A:
undetectable		 1nbiC-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 TYR A 187
ALA A 192
SER A 191
GLY A 149
SER A 219
 None
 1.09A 1nbiD-5no5A:
undetectable		 1nbiD-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5no5 ABYA5
(Verrucosispora) 		4 / 7 GLY A 332
HIS A 327
ASP A 329
PRO A 338
 None
 1.18A 1th6A-5no5A:
undetectable		 1th6A-5no5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5no5 ABYA5
(Verrucosispora) 		4 / 4 GLY A 150
SER A 217
ILE A 306
HIS A 331
 None
 1.02A 1yajJ-5no5A:
10.6		 1yajJ-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5no5 ABYA5
(Verrucosispora) 		4 / 4 LEU A 264
THR A 263
ILE A 307
HIS A 331
 None
 1.31A 2jfaB-5no5A:
undetectable		 2jfaB-5no5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5no5 ABYA5
(Verrucosispora) 		4 / 7 VAL A  31
ALA A  42
PRO A  89
TRP A  63
 None
 0.95A 2q6oA-5no5A:
undetectable		 2q6oA-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.11A 3keeA-5no5A:
undetectable		 3keeA-5no5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.05A 3keeB-5no5A:
undetectable		 3keeB-5no5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.01A 3keeC-5no5A:
undetectable		 3keeC-5no5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.04A 3keeD-5no5A:
undetectable		 3keeD-5no5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.05A 3sueA-5no5A:
undetectable		 3sueA-5no5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.09A 3sueB-5no5A:
undetectable		 3sueB-5no5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.01A 3sueC-5no5A:
undetectable		 3sueC-5no5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5no5 ABYA5
(Verrucosispora) 		5 / 10 PHE A 246
VAL A 279
PHE A 247
ILE A 151
PHE A 218
 None
 1.35A 3t3qD-5no5A:
undetectable		 3t3qD-5no5A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5no5 ABYA5
(Verrucosispora) 		4 / 6 ILE A 236
ILE A 161
TRP A 158
MET A 147
 None
 1.44A 3weoA-5no5A:
undetectable		 3weoA-5no5A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 ASP A 200
LEU A 199
GLY A 196
PHE A 195
ALA A 203
 None
 1.31A 4eb4A-5no5A:
undetectable		 4eb4A-5no5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 ASP A 200
LEU A 199
GLY A 196
PHE A 195
ALA A 203
 None
 1.29A 4eb4B-5no5A:
undetectable		 4eb4B-5no5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 9 VAL A 259
GLY A 332
TYR A  30
VAL A 330
PRO A 334
 None
 1.17A 5zniA-5no5A:
undetectable		 5zniA-5no5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5no5 ABYA5
(Verrucosispora) 		5 / 12 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.01A 6c2mC-5no5A:
undetectable		 6c2mC-5no5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5no5 ABYA5
(Verrucosispora) 		5 / 10 LEU A 233
LEU A 145
ILE A 294
PRO A 295
SER A 352
 None
 1.50A 6dm2B-5no5A:
3.5
6dm2C-5no5A:
2.8		 6dm2B-5no5A:
17.44
6dm2C-5no5A:
17.44