SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.13A 1ddrB-5nofA:
undetectable		 1ddrB-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.11A 1ddsA-5nofA:
undetectable		 1ddsA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.01A 1ddsB-5nofA:
undetectable		 1ddsB-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.06A 1dhiB-5nofA:
undetectable		 1dhiB-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 175
PHE A  22
ILE A 155
PRO A 154
LEU A  37
 None
 1.16A 1dlsA-5nofA:
undetectable		 1dlsA-5nofA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.08A 1draB-5nofA:
undetectable		 1draB-5nofA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.11A 1dyiA-5nofA:
undetectable		 1dyiA-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.03A 1dyiB-5nofA:
undetectable		 1dyiB-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.17A 1jolA-5nofA:
undetectable		 1jolA-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.11A 1jolB-5nofA:
undetectable		 1jolB-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.09A 1rx3A-5nofA:
undetectable		 1rx3A-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.12A 1tdrA-5nofA:
undetectable		 1tdrA-5nofA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 124
ARG A 130
LEU A 122
ASN A 123
 None
 1.15A 1y0xX-5nofA:
undetectable		 1y0xX-5nofA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 5 LEU A  66
GLY A 103
PRO A 177
ALA A 178
 None
 0.90A 2aohA-5nofA:
undetectable		 2aohA-5nofA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.08A 2drcB-5nofA:
undetectable		 2drcB-5nofA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.23A 2zzaA-5nofA:
undetectable		 2zzaA-5nofA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.23A 2zzaB-5nofA:
undetectable		 2zzaB-5nofA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.12A 3dauA-5nofA:
undetectable		 3dauA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 8 PHE A 168
VAL A 105
VAL A 167
GLY A 172
 None
 0.93A 3hjoA-5nofA:
undetectable		 3hjoA-5nofA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.32A 3ia4B-5nofA:
undetectable		 3ia4B-5nofA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 7 PHE A 168
VAL A 105
VAL A 167
GLY A 172
 None
 0.94A 3kmoB-5nofA:
undetectable		 3kmoB-5nofA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.12A 3ql0A-5nofA:
undetectable		 3ql0A-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN A 310
GLY A 270
GLY A 272
ALA A 266
GLY A 269
 None
 1.10A 3tegA-5nofA:
undetectable		 3tegA-5nofA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.09A 4dfrB-5nofA:
undetectable		 4dfrB-5nofA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.06A 4gh8A-5nofA:
undetectable		 4gh8A-5nofA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A  61
LEU A 152
ASN A 176
ALA A 199
ALA A  54
 None
 1.17A 4pclA-5nofA:
2.5		 4pclA-5nofA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.14A 4qleA-5nofA:
undetectable		 4qleA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.14A 4qleB-5nofA:
undetectable		 4qleB-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.09A 4qlfA-5nofA:
undetectable		 4qlfA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.13A 4qlgA-5nofA:
undetectable		 4qlgA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.11A 4qlgB-5nofA:
undetectable		 4qlgB-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.07A 4rgcA-5nofA:
undetectable		 4rgcA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  74
GLY A  76
ASN A 188
ASP A  71
ALA A  88
 None
ZN  A 502 ( 4.8A)
None
None
None
 1.13A 4uckB-5nofA:
undetectable		 4uckB-5nofA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.10A 4x5fA-5nofA:
undetectable		 4x5fA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.09A 4x5fB-5nofA:
undetectable		 4x5fB-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.09A 4x5gA-5nofA:
undetectable		 4x5gA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.11A 4x5hA-5nofA:
undetectable		 4x5hA-5nofA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 9 SER A  86
ALA A 145
TYR A 148
PHE A 142
THR A 141
 None
 1.27A 4z7fE-5nofA:
0.0		 4z7fE-5nofA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.15A 5e8qB-5nofA:
undetectable		 5e8qB-5nofA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.12A 5hi6A-5nofA:
undetectable		 5hi6A-5nofA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 171
ALA A  56
LEU A  21
ILE A  33
LEU A  37
 None
 1.17A 5hi6B-5nofA:
undetectable		 5hi6B-5nofA:
22.70