SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5noi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		3 / 3 VAL A 431
ASP A 432
GLU A 507
 None
 0.62A 2qeuA-5noiA:
undetectable		 2qeuA-5noiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		3 / 3 VAL A 431
ASP A 432
GLU A 507
 None
 0.64A 2qeuC-5noiA:
undetectable		 2qeuC-5noiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		3 / 3 ASN A 354
ASP A 385
GLN A 382
 None
 0.43A 3eeyC-5noiA:
undetectable		 3eeyC-5noiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		3 / 3 ASN A 354
ASP A 385
GLN A 382
 None
 0.44A 3eeyD-5noiA:
undetectable		 3eeyD-5noiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		3 / 3 ASN A 354
ASP A 385
GLN A 382
 None
 0.43A 3eeyE-5noiA:
undetectable		 3eeyE-5noiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 7 PHE A 316
GLU A 336
VAL A 345
TRP A 347
 None
 1.39A 3nloA-5noiA:
undetectable
3nloB-5noiA:
undetectable		 3nloA-5noiA:
19.34
3nloB-5noiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 6 VAL A 345
TRP A 347
PHE A 316
GLU A 336
 None
 1.30A 4v3wA-5noiA:
undetectable
4v3wB-5noiA:
undetectable		 4v3wA-5noiA:
19.34
4v3wB-5noiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 7 PHE A 316
GLU A 336
VAL A 345
TRP A 347
 None
 1.30A 4v3wA-5noiA:
undetectable
4v3wB-5noiA:
undetectable		 4v3wA-5noiA:
19.34
4v3wB-5noiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		5 / 12 TYR A 486
LEU A 437
LEU A 436
ILE A 480
ILE A 475
 None
 1.13A 5h8tA-5noiA:
undetectable		 5h8tA-5noiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 7 VAL A 345
TRP A 347
PHE A 316
GLU A 336
 None
 1.32A 5vujA-5noiA:
undetectable
5vujB-5noiA:
undetectable		 5vujA-5noiA:
19.34
5vujB-5noiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 7 PHE A 316
GLU A 336
VAL A 345
TRP A 347
 None
 1.31A 5vujA-5noiA:
undetectable
5vujB-5noiA:
undetectable		 5vujA-5noiA:
19.34
5vujB-5noiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5noi ROUNDABOUT HOMOLOG 2
(Homo
sapiens) 		4 / 7 PHE A 316
GLU A 336
VAL A 345
TRP A 347
 None
 1.34A 5vv5A-5noiA:
undetectable
5vv5B-5noiA:
undetectable		 5vv5A-5noiA:
19.75
5vv5B-5noiA:
19.75