SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5non'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
93H  A 501 (-3.4A)
93H  A 501 (-4.5A)
93H  A 501 (-4.3A)
 1.25A 2wekA-5nonA:
undetectable		 2wekA-5nonA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 6 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
93H  A 501 (-3.4A)
93H  A 501 (-4.5A)
93H  A 501 (-4.3A)
 1.24A 2wekB-5nonA:
undetectable		 2wekB-5nonA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		3 / 3 PRO A 105
GLU A 128
TYR A 108
 None
 0.73A 2zmbA-5nonA:
undetectable		 2zmbA-5nonA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.33A 3ag2J-5nonA:
undetectable		 3ag2J-5nonA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 6 LYS A 111
GLY A  90
GLY A  89
ASP A  88
 None
 0.65A 5a06D-5nonA:
undetectable		 5a06D-5nonA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		5 / 11 ASP A 185
ILE A 143
TYR A  63
ILE A  59
ILE A 187
 None
 1.14A 5hw8G-5nonA:
undetectable		 5hw8G-5nonA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.26A 5wauJ-5nonA:
undetectable		 5wauJ-5nonA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.28A 5x19J-5nonA:
undetectable		 5x19J-5nonA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.24A 5x1bJ-5nonA:
undetectable		 5x1bJ-5nonA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.25A 5x1bW-5nonA:
undetectable		 5x1bW-5nonA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5non S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
93H  A 501 (-4.2A)
None
None
 1.27A 5x1fW-5nonA:
undetectable		 5x1fW-5nonA:
18.18