SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5np9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 12 ILE A  17
THR A  21
ALA A  25
GLY A  47
GLY A  51
 None
 1.05A 1rjdA-5np9A:
undetectable		 1rjdA-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 12 ILE A  17
THR A  21
ALA A  25
GLY A  47
GLY A  51
 None
 1.07A 1rjdB-5np9A:
undetectable		 1rjdB-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 12 ILE A  17
THR A  21
ALA A  25
GLY A  47
GLY A  51
 None
 1.06A 1rjdC-5np9A:
undetectable		 1rjdC-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 4 LEU A  33
ILE A 134
ILE A  17
ALA A  18
 None
 0.89A 2i30A-5np9A:
undetectable		 2i30A-5np9A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 10 ILE A 134
LEU A 150
LEU A 120
ILE A 122
PHE A  44
 None
 1.12A 2w9sD-5np9A:
2.8		 2w9sD-5np9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 10 ILE A 134
LEU A 150
LEU A 120
ILE A 122
PHE A  44
 None
 1.12A 2w9sF-5np9A:
2.8		 2w9sF-5np9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		5 / 9 GLY A  53
PHE A 136
PHE A  48
GLY A  47
PHE A  44
 None
 1.43A 3ko0A-5np9A:
undetectable
3ko0C-5np9A:
undetectable		 3ko0A-5np9A:
19.79
3ko0C-5np9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 6 PHE A  44
LEU A 120
ALA A  22
LEU A 104
 None
 0.83A 3t3zA-5np9A:
undetectable		 3t3zA-5np9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 6 PHE A  44
LEU A 120
ALA A  22
LEU A 104
 None
 0.86A 3t3zB-5np9A:
undetectable		 3t3zB-5np9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 6 PHE A  44
LEU A 120
ALA A  22
LEU A 104
 None
 0.84A 3t3zD-5np9A:
undetectable		 3t3zD-5np9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 5 THR A  64
ILE A  66
LYS A  67
GLU A  68
 None
 1.18A 4ac9C-5np9A:
undetectable		 4ac9C-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 5 THR A  64
ILE A  66
LYS A  67
GLU A  68
 None
 1.19A 4acaC-5np9A:
undetectable		 4acaC-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 5 THR A  64
ILE A  66
LYS A  67
GLU A  68
 None
 1.16A 4acbC-5np9A:
2.6		 4acbC-5np9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 6 GLU A 106
PHE A  44
PHE A  48
HIS A  78
 MG  A 202 ( 2.5A)
None
None
None
 1.25A 4uciA-5np9A:
undetectable		 4uciA-5np9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 7 GLU A 106
PHE A  44
PHE A  48
HIS A  78
 MG  A 202 ( 2.5A)
None
None
None
 1.20A 4uciB-5np9A:
undetectable		 4uciB-5np9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE
(Bacillus
subtilis) 		4 / 5 ILE A  17
LEU A  52
GLY A  51
PHE A  48
 None
 0.85A 5kmdC-5np9A:
undetectable
5kmdD-5np9A:
undetectable		 5kmdC-5np9A:
14.29
5kmdD-5np9A:
14.29