SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		5 / 12 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.43A 3nyaA-5nphH:
undetectable		 3nyaA-5nphH:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 8 VAL H 116
LEU H  18
LEU H  86
ILE H  81
 None
 0.87A 3u5kC-5nphH:
undetectable		 3u5kC-5nphH:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL H 116
LEU H  18
LEU H  86
ILE H  81
 None
 0.90A 4a9jA-5nphH:
undetectable		 4a9jA-5nphH:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL H 116
LEU H  18
LEU H  86
ILE H  81
 None
 0.91A 4a9jB-5nphH:
undetectable		 4a9jB-5nphH:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		3 / 3 LYS H  52
PRO H  53
SER H  54
 None
 0.36A 4k50I-5nphH:
undetectable		 4k50I-5nphH:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 109
 None
 0.42A 4m7kH-5nphH:
22.9		 4m7kH-5nphH:
53.26