SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5npi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		6 / 12 GLN A 229
LEU A 236
PHE A 238
VAL A  37
ALA A  97
TRP A 110
 None
 0.64A 1h8sA-5npiA:
22.4		 1h8sA-5npiA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 8 VAL A 116
LEU A  18
LEU A  86
ILE A  81
 None
 0.84A 3u5kC-5npiA:
undetectable		 3u5kC-5npiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL A 116
LEU A  18
LEU A  86
ILE A  81
 None
 0.85A 4a9jA-5npiA:
undetectable		 4a9jA-5npiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL A 116
LEU A  18
LEU A  86
ILE A  81
 None
 0.85A 4a9jB-5npiA:
undetectable		 4a9jB-5npiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		4 / 5 VAL A 116
LEU A  18
LEU A  86
ILE A  81
 None
 0.90A 4a9jC-5npiA:
undetectable		 4a9jC-5npiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5
(Mus
musculus) 		3 / 3 LYS A  52
PRO A  53
SER A  54
 None
 0.34A 4k50I-5npiA:
undetectable		 4k50I-5npiA:
19.18