SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5npt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWJ_B_BAXB1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	5npt	TELOMERASE REVERSE TRANSCRIPTASE (Ogataea polymorpha)	3 / 3	ILE A 115 ASP A 4 PHE A 3	None	0.61A	1uwjB-5nptA: undetectable	1uwjB-5nptA: 15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA303_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	5npt	TELOMERASE REVERSE TRANSCRIPTASE (Ogataea polymorpha)	3 / 3	GLU A 73 TYR A 72 ARG A 43	None	0.66A	5uunA-5nptA: undetectable	5uunA-5nptA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB305_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	5npt	TELOMERASE REVERSE TRANSCRIPTASE (Ogataea polymorpha)	3 / 3	GLU A 73 TYR A 72 ARG A 43	None	0.64A	5uunB-5nptA: undetectable	5uunB-5nptA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_A_FFOA403_0 (THYMIDYLATE SYNTHASE)	5npt	TELOMERASE REVERSE TRANSCRIPTASE (Ogataea polymorpha)	5 / 12	PHE A 109 ASN A 127 LEU A 63 PHE A 121 TYR A 66	None	1.02A	6r2eA-5nptA: undetectable	6r2eA-5nptA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UWJ_B_BAXB1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","5npt","TELOMERASE REVERSE TRANSCRIPTASE","Ogataea polymorpha",3,"ILE A 115;ASP A   4;PHE A   3","None","0.61A","1uwjB-5nptA:undetectable","1uwjB-5nptA:15.19"],["5UUN_A_ACTA303_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","5npt","TELOMERASE REVERSE TRANSCRIPTASE","Ogataea polymorpha",3,"GLU A  73;TYR A  72;ARG A  43","None","0.66A","5uunA-5nptA:undetectable","5uunA-5nptA:undetectable"],["5UUN_B_ACTB305_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","5npt","TELOMERASE REVERSE TRANSCRIPTASE","Ogataea polymorpha",3,"GLU A  73;TYR A  72;ARG A  43","None","0.64A","5uunB-5nptA:undetectable","5uunB-5nptA:undetectable"],["6R2E_A_FFOA403_0","THYMIDYLATE SYNTHASE","5npt","TELOMERASE REVERSE TRANSCRIPTASE","Ogataea polymorpha",5,"PHE A 109;ASN A 127;LEU A  63;PHE A 121;TYR A  66","None","1.02A","6r2eA-5nptA:undetectable","6r2eA-5nptA:undetectable"]]