SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5npu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5npu ANC27
(synthetic
construct) 		5 / 12 ALA A 387
ARG A  62
GLY A 218
GLU A 226
ARG A 406
 None
 1.38A 1agmA-5npuA:
undetectable		 1agmA-5npuA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5npu ANC27
(synthetic
construct) 		5 / 12 ALA A 387
ARG A  62
GLY A 218
GLU A 226
ARG A 406
 None
 1.38A 1agmA-5npuA:
undetectable		 1agmA-5npuA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5npu ANC27
(synthetic
construct) 		4 / 6 TYR A 261
ASP A 275
VAL A 270
GLY A 263
 None
 1.12A 1ekjC-5npuA:
2.1
1ekjD-5npuA:
undetectable		 1ekjC-5npuA:
undetectable
1ekjD-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5npu ANC27
(synthetic
construct) 		4 / 6 ASP A 275
VAL A 270
GLY A 263
TYR A 261
 None
 1.17A 1ekjC-5npuA:
2.1
1ekjD-5npuA:
undetectable		 1ekjC-5npuA:
undetectable
1ekjD-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5npu ANC27
(synthetic
construct) 		4 / 6 VAL A   5
GLY A   6
LEU A  32
GLU A 165
 None
 1.03A 1fduD-5npuA:
2.4		 1fduD-5npuA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5npu ANC27
(synthetic
construct) 		6 / 12 ARG A  12
LEU A  13
LEU A  18
VAL A  66
LEU A 156
ALA A 155
 None
 1.30A 1gseB-5npuA:
undetectable		 1gseB-5npuA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5npu ANC27
(synthetic
construct) 		4 / 6 ASN A 467
ASN A 468
ILE A 485
GLY A 470
 None
MG  A 601 ( 1.7A)
None
None
 0.87A 1oniA-5npuA:
undetectable
1oniB-5npuA:
undetectable		 1oniA-5npuA:
undetectable
1oniB-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 5npu ANC27
(synthetic
construct) 		5 / 12 ALA A 387
ARG A  62
GLY A 218
GLU A 226
ARG A 406
 None
 1.35A 2f6dA-5npuA:
undetectable		 2f6dA-5npuA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5npu ANC27
(synthetic
construct) 		5 / 11 ILE A 386
GLU A  58
GLY A 417
THR A 447
GLU A 388
 None
 1.35A 2fn1A-5npuA:
undetectable		 2fn1A-5npuA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5npu ANC27
(synthetic
construct) 		5 / 10 HIS A  21
VAL A  70
ILE A  97
LEU A   9
GLY A   6
 None
 1.14A 2xf3A-5npuA:
undetectable		 2xf3A-5npuA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5npu ANC27
(synthetic
construct) 		3 / 3 VAL A 535
ASN A 487
TRP A 488
 None
 1.05A 2y00B-5npuA:
undetectable		 2y00B-5npuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5npu ANC27
(synthetic
construct) 		5 / 11 LEU A   9
ALA A  10
LEU A  42
ALA A  68
VAL A  70
 None
 1.17A 3e22B-5npuA:
undetectable		 3e22B-5npuA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5npu ANC27
(synthetic
construct) 		5 / 11 LEU A   9
ALA A  10
LEU A  42
ALA A  68
VAL A  70
 None
 1.16A 3e22D-5npuA:
undetectable		 3e22D-5npuA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5npu ANC27
(synthetic
construct) 		5 / 12 TYR A  28
TYR A 123
ASP A 120
GLY A 107
SER A 108
 None
 1.43A 3hiiA-5npuA:
undetectable		 3hiiA-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5npu ANC27
(synthetic
construct) 		5 / 12 TYR A  28
TYR A 123
ASP A 120
GLY A 107
SER A 108
 None
 1.41A 3hiiB-5npuA:
undetectable		 3hiiB-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5npu ANC27
(synthetic
construct) 		5 / 12 GLY A  54
PRO A 421
ASN A  49
ALA A 422
PHE A  81
 None
 1.07A 3p2kC-5npuA:
3.6		 3p2kC-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5npu ANC27
(synthetic
construct) 		5 / 12 LEU A   9
LEU A  96
GLN A 124
ILE A 164
TYR A 163
 None
 1.45A 4a79A-5npuA:
undetectable		 4a79A-5npuA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5npu ANC27
(synthetic
construct) 		5 / 12 ASN A  29
GLN A 124
ALA A  77
SER A  74
TYR A 123
 None
 1.41A 4ejwA-5npuA:
undetectable		 4ejwA-5npuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5npu ANC27
(synthetic
construct) 		4 / 5 ALA A 422
HIS A 415
ALA A  83
GLU A 410
 None
TPP  A 602 (-3.0A)
None
None
 1.47A 5a06C-5npuA:
3.1
5a06D-5npuA:
2.2		 5a06C-5npuA:
undetectable
5a06D-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5npu ANC27
(synthetic
construct) 		5 / 12 ALA A 246
GLY A 284
GLY A 218
ALA A 223
LEU A 283
 None
 1.11A 5c0oE-5npuA:
5.3		 5c0oE-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5npu ANC27
(synthetic
construct) 		4 / 5 HIS A 150
ILE A 148
ILE A 152
TYR A   8
 None
 1.13A 5dnvA-5npuA:
2.2		 5dnvA-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5npu ANC27
(synthetic
construct) 		5 / 12 ASP A 391
THR A 472
GLY A 440
SER A 443
THR A 389
 None
TPP  A 602 (-3.4A)
TPP  A 602 (-3.3A)
TPP  A 602 (-2.7A)
TPP  A 602 ( 4.5A)
 1.32A 5hfjB-5npuA:
undetectable		 5hfjB-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5npu ANC27
(synthetic
construct) 		4 / 5 SER A  98
VAL A  71
GLY A  76
ALA A  77
 None
 0.95A 5k50A-5npuA:
undetectable		 5k50A-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5npu ANC27
(synthetic
construct) 		5 / 12 GLY A 390
SER A 392
ASN A 467
LEU A 531
LEU A 437
 TPP  A 602 ( 3.7A)
TPP  A 602 ( 4.5A)
None
None
None
 1.24A 5nwwA-5npuA:
undetectable		 5nwwA-5npuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5npu ANC27
(synthetic
construct) 		5 / 12 VAL A 451
GLY A 506
VAL A 455
ALA A 491
ASP A 489
 None
 1.10A 5x7fA-5npuA:
undetectable		 5x7fA-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5npu ANC27
(synthetic
construct) 		5 / 12 LEU A 215
GLU A 271
VAL A 274
THR A 260
THR A 542
 None
 1.24A 5xipC-5npuA:
3.7		 5xipC-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5npu ANC27
(synthetic
construct) 		5 / 12 LEU A 215
GLU A 271
VAL A 274
THR A 260
THR A 542
 None
 1.24A 5xipD-5npuA:
2.1		 5xipD-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5npu ANC27
(synthetic
construct) 		5 / 12 ILE A 152
ALA A 155
ILE A  97
ALA A 134
LEU A  18
 None
 1.18A 6a5zD-5npuA:
undetectable		 6a5zD-5npuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5npu ANC27
(synthetic
construct) 		3 / 3 PHE A 205
ASP A 204
LYS A 208
 None
 0.62A 6awtD-5npuA:
undetectable		 6awtD-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5npu ANC27
(synthetic
construct) 		5 / 10 PHE A 205
ILE A 281
LEU A 220
ASP A 308
LEU A 306
 None
 1.44A 6r2eB-5npuA:
undetectable		 6r2eB-5npuA:
undetectable