SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5npy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 11 VAL A 197
VAL A 400
SER A 375
LEU A 448
LEU A 199
 None
 1.09A 1eqgB-5npyA:
undetectable		 1eqgB-5npyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 9 VAL A 144
GLY A 146
ILE A 147
ILE A 152
ILE A 179
 None
 0.94A 1hshB-5npyA:
undetectable		 1hshB-5npyA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 8 ILE A 352
LEU A 310
PHE A 224
GLY A 280
 None
 1.04A 1os6A-5npyA:
undetectable		 1os6A-5npyA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 310
ILE A 352
SER A 382
PHE A 212
LEU A 294
 None
 1.00A 1xdkB-5npyA:
undetectable		 1xdkB-5npyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A 327
LEU A 334
VAL A 350
ILE A 352
SER A 382
 None
 1.19A 1zq9A-5npyA:
undetectable		 1zq9A-5npyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 6 ILE A 195
MET A 435
THR A 436
LEU A 437
 None
 1.01A 2einN-5npyA:
undetectable
2einW-5npyA:
undetectable		 2einN-5npyA:
20.59
2einW-5npyA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 6 THR A 244
ARG A 246
ASN A 200
ASP A 203
 None
 1.20A 2okcA-5npyA:
undetectable		 2okcA-5npyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 9 LEU A 248
ILE A 229
ALA A 242
GLU A 270
GLY A 272
 None
 1.21A 2v0mB-5npyA:
undetectable		 2v0mB-5npyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 421
LEU A 466
TYR A 377
LEU A 199
GLY A 194
 None
 0.99A 3n8wA-5npyA:
undetectable		 3n8wA-5npyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 421
VAL A 197
LEU A 466
LEU A 199
GLY A 194
 None
 1.10A 3pghA-5npyA:
undetectable		 3pghA-5npyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 421
LEU A 466
TYR A 377
LEU A 199
GLY A 194
 None
 1.06A 3rr3C-5npyA:
undetectable		 3rr3C-5npyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 421
LEU A 466
TYR A 377
LEU A 199
GLY A 194
 None
 1.07A 3rr3D-5npyA:
undetectable		 3rr3D-5npyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		5 / 9 VAL A 144
GLY A 146
ILE A 147
ILE A 152
ILE A 179
 None
 0.98A 3s43A-5npyA:
undetectable		 3s43A-5npyA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 8 ILE A 352
LEU A 310
PHE A 224
GLY A 280
 None
 1.01A 3selX-5npyA:
undetectable		 3selX-5npyA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 6 ILE A 195
MET A 435
THR A 436
LEU A 437
 None
 1.02A 3wg7N-5npyA:
undetectable
3wg7W-5npyA:
undetectable		 3wg7N-5npyA:
20.59
3wg7W-5npyA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 8 ILE A 484
ILE A 490
VAL A 144
GLY A 146
 None
 0.81A 4acaC-5npyA:
undetectable		 4acaC-5npyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 7 ILE A 352
LEU A 310
PHE A 224
GLY A 280
 None
 1.01A 4hc3A-5npyA:
undetectable		 4hc3A-5npyA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		3 / 3 SER A 456
MET A 430
ASP A 203
 None
 0.74A 4mm4B-5npyA:
undetectable		 4mm4B-5npyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 5 TYR A 403
GLN A 374
SER A 358
ASP A 210
 None
 1.23A 4qtuB-5npyA:
undetectable		 4qtuB-5npyA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5npy FLAGELLAR BASAL BODY
PROTEIN
(Helicobacter
pylori) 		4 / 4 ASN A 226
ILE A 240
TYR A 266
PHE A 264
 144  A 701 (-4.3A)
None
None
None
 1.44A 5igvA-5npyA:
undetectable		 5igvA-5npyA:
20.87