SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 8 SER A 358
SER A 317
ALA A 315
ILE A 244
 None
EDO  A 625 ( 4.5A)
None
None
 0.95A 1gm7A-5nqaA:
undetectable
1gm7B-5nqaA:
undetectable		 1gm7A-5nqaA:
undetectable
1gm7B-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 5 CYH A 253
PRO A 303
THR A 137
THR A 224
 None
 1.23A 1ymxB-5nqaA:
undetectable		 1ymxB-5nqaA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 5 CYH A 253
PRO A 356
THR A 137
THR A 224
 None
 1.29A 1ymxB-5nqaA:
undetectable		 1ymxB-5nqaA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 ILE A 244
LEU A 226
ASP A 227
PRO A 254
ILE A 256
 None
None
None
None
EDO  A 601 ( 4.8A)
 1.20A 1zq9A-5nqaA:
undetectable		 1zq9A-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 6 ASP A 521
THR A 489
GLU A 439
GLU A 493
 None
 1.47A 2dttB-5nqaA:
undetectable
2dttC-5nqaA:
undetectable		 2dttB-5nqaA:
25.69
2dttC-5nqaA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 6 ASP A 521
THR A 489
GLU A 493
GLU A 439
 None
 1.43A 2dttB-5nqaA:
undetectable
2dttC-5nqaA:
undetectable		 2dttB-5nqaA:
25.69
2dttC-5nqaA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 10 HIS A 393
THR A 489
GLU A 493
GLU A 439
ASP A 521
 None
 1.48A 2dttD-5nqaA:
undetectable
2dttF-5nqaA:
undetectable		 2dttD-5nqaA:
25.69
2dttF-5nqaA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 LEU A 152
SER A 149
ILE A 102
ARG A 179
TYR A 181
 None
None
None
None
EDO  A 606 (-4.6A)
 1.45A 2htuA-5nqaA:
undetectable		 2htuA-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 6 LEU A 474
LEU A 458
ILE A 453
ARG A 449
 None
 1.03A 2rlfA-5nqaA:
undetectable
2rlfB-5nqaA:
undetectable		 2rlfA-5nqaA:
22.08
2rlfB-5nqaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 6 LEU A 474
LEU A 458
ILE A 453
ARG A 449
 None
 0.99A 2rlfC-5nqaA:
undetectable
2rlfD-5nqaA:
undetectable		 2rlfC-5nqaA:
22.08
2rlfD-5nqaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 SER A 462
ALA A 470
VAL A 513
GLY A 514
MET A 515
 None
 0.80A 3f8wA-5nqaA:
undetectable		 3f8wA-5nqaA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 SER A 462
ALA A 470
VAL A 513
GLY A 514
MET A 515
 None
 0.81A 3f8wC-5nqaA:
undetectable		 3f8wC-5nqaA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 4 LEU A 237
ALA A 315
VAL A 252
PRO A 254
 None
 1.02A 3gv1B-5nqaA:
undetectable		 3gv1B-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 GLU A 231
ILE A 259
LEU A 106
GLY A  78
PHE A 266
 EDO  A 604 (-3.4A)
None
None
None
None
 1.11A 3k2hA-5nqaA:
undetectable		 3k2hA-5nqaA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 GLU A 231
ILE A 259
LEU A 106
GLY A  78
PHE A 266
 EDO  A 604 (-3.4A)
None
None
None
None
 1.08A 3k2hB-5nqaA:
2.0		 3k2hB-5nqaA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 7 PHE A 486
GLY A 446
PHE A 576
PHE A 533
 None
 1.00A 3ko0D-5nqaA:
undetectable
3ko0E-5nqaA:
undetectable		 3ko0D-5nqaA:
22.88
3ko0E-5nqaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 8 PHE A 533
PHE A 486
GLY A 446
PHE A 576
 None
 0.81A 3ko0O-5nqaA:
undetectable
3ko0Q-5nqaA:
undetectable		 3ko0O-5nqaA:
22.88
3ko0Q-5nqaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 6 SER A 162
LEU A 159
HIS A 156
THR A 161
 None
None
None
EDO  A 604 (-3.9A)
 1.41A 3thrB-5nqaA:
undetectable		 3thrB-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 11 PHE A 278
ALA A 382
ALA A 383
LEU A 428
GLN A 347
 None
 1.12A 4j6cA-5nqaA:
undetectable		 4j6cA-5nqaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 PHE A 278
ALA A 382
ALA A 383
LEU A 428
GLN A 347
 None
 1.05A 4j6dA-5nqaA:
undetectable		 4j6dA-5nqaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 PHE A 278
ALA A 382
ALA A 383
LEU A 428
GLN A 347
 None
 1.08A 4j6dB-5nqaA:
undetectable		 4j6dB-5nqaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		3 / 3 ASP A 260
TYR A 267
TRP A 261
 EDO  A 615 (-2.9A)
None
EDO  A 615 ( 4.1A)
 1.02A 4p7nA-5nqaA:
undetectable		 4p7nA-5nqaA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		3 / 3 SER A 473
LEU A 502
MET A 515
 None
 0.86A 5ikrB-5nqaA:
undetectable		 5ikrB-5nqaA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		3 / 3 GLY A 335
ASN A 378
ARG A 209
 EDO  A 628 (-3.5A)
None
None
 0.80A 5w7bD-5nqaA:
undetectable		 5w7bD-5nqaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		5 / 12 HIS A 287
GLY A 350
VAL A 345
GLY A 276
GLY A 277
 None
None
None
None
EDO  A 603 (-4.7A)
 0.89A 6brdB-5nqaA:
undetectable		 6brdB-5nqaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 7 ASN A 378
GLY A 311
VAL A 345
LEU A 341
 None
EDO  A 601 ( 3.8A)
None
None
 0.69A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens) 		4 / 7 ASN A 378
GLY A 312
VAL A 345
LEU A 341
 None
EDO  A 612 ( 3.2A)
None
None
 0.73A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88