SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 11 ILE A 127
ALA A 346
GLY A 394
GLU A 120
ASN A 398
 ILE  A 127 ( 0.7A)
ALA  A 346 ( 0.0A)
GLY  A 394 ( 0.0A)
GLU  A 120 ( 0.5A)
ASN  A 398 ( 0.6A)
 1.15A 1n6cA-5nqfA:
undetectable		 1n6cA-5nqfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		3 / 3 SER A 125
GLY A 126
ARG A 143
 SER  A 125 ( 0.0A)
GLY  A 126 ( 0.0A)
ARG  A 143 ( 0.6A)
 0.67A 1t9wA-5nqfA:
undetectable		 1t9wA-5nqfA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
RHOPTRY NECK PROTEIN
2
(Plasmodium
falciparum;
Plasmodium
vivax) 		4 / 4 MET B2045
ALA A 253
TYR A 251
ILE A 252
 MET  B2045 ( 0.0A)
ALA  A 253 ( 0.0A)
TYR  A 251 ( 1.3A)
ILE  A 252 ( 0.7A)
 1.27A 1upfD-5nqfB:
undetectable		 1upfD-5nqfB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		3 / 3 LEU A 216
ASN A 210
ARG A 199
 LEU  A 216 ( 0.6A)
ASN  A 210 ( 0.6A)
ARG  A 199 ( 0.6A)
 0.87A 2qhfA-5nqfA:
undetectable		 2qhfA-5nqfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.49A 2zvjA-5nqfA:
undetectable		 2zvjA-5nqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 3mekA-5nqfA:
undetectable		 3mekA-5nqfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.48A 3s68A-5nqfA:
undetectable		 3s68A-5nqfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		4 / 5 TYR A 117
PHE A 312
PRO A 416
LEU A 419
 TYR  A 117 ( 1.3A)
PHE  A 312 ( 1.3A)
PRO  A 416 ( 1.1A)
LEU  A 419 ( 0.5A)
 1.48A 3tgvC-5nqfA:
undetectable		 3tgvC-5nqfA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		4 / 6 TYR A 117
PHE A 312
PRO A 416
LEU A 419
 TYR  A 117 ( 1.3A)
PHE  A 312 ( 1.3A)
PRO  A 416 ( 1.1A)
LEU  A 419 ( 0.5A)
 1.34A 3tgvD-5nqfA:
undetectable		 3tgvD-5nqfA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 180
GLY A 179
ILE A 158
VAL A 239
ILE A 252
 GLY  A 180 ( 0.0A)
GLY  A 179 ( 0.0A)
ILE  A 158 ( 0.7A)
VAL  A 239 ( 0.6A)
ILE  A 252 ( 0.7A)
 1.18A 4fglA-5nqfA:
undetectable
4fglB-5nqfA:
undetectable		 4fglA-5nqfA:
19.47
4fglB-5nqfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 11 ILE A 127
ALA A 346
GLY A 394
GLU A 120
ASN A 398
 ILE  A 127 ( 0.7A)
ALA  A 346 ( 0.0A)
GLY  A 394 ( 0.0A)
GLU  A 120 ( 0.5A)
ASN  A 398 ( 0.6A)
 1.13A 4jdsC-5nqfA:
undetectable		 4jdsC-5nqfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nqf APICAL MEMBRANE
ANTIGEN 1
RHOPTRY NECK PROTEIN
2
(Plasmodium
falciparum;
Plasmodium
vivax) 		4 / 6 GLY B2044
PHE A 276
ILE A 252
PHE A 274
 GLY  B2044 ( 0.0A)
PHE  A 276 ( 1.3A)
ILE  A 252 ( 0.7A)
PHE  A 274 ( 1.3A)
 1.05A 4qogA-5nqfB:
undetectable
4qogB-5nqfB:
undetectable		 4qogA-5nqfB:
10.67
4qogB-5nqfB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.19A 4zdyA-5nqfA:
undetectable		 4zdyA-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.16A 4ze2A-5nqfA:
undetectable		 4ze2A-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.31A 5ccmA-5nqfA:
undetectable		 5ccmA-5nqfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.20A 5eslA-5nqfA:
undetectable		 5eslA-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.48A 5fhrA-5nqfA:
undetectable		 5fhrA-5nqfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 5xxdA-5nqfA:
undetectable		 5xxdA-5nqfA:
20.51