SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_0 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	5nqs	PROTEIN TOPLESS (Arabidopsis thaliana)	4 / 4	THR A 165 LEU A 166 LEU A 174 GLN A 177	None	1.07A	1fbmA-5nqsA: undetectable	1fbmA-5nqsA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFG_B_LEUB289_0 (GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT)	5nqs	PROTEIN TOPLESS (Arabidopsis thaliana)	3 / 3	PHE A 34 SER A 3 SER A 5	None	0.88A	3ufgB-5nqsA: undetectable	3ufgB-5nqsA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1801_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5nqs	PROTEIN TOPLESS (Arabidopsis thaliana)	4 / 6	ILE A 72 ILE A 96 LEU A 101 PHE A 104	None	0.95A	5vkqA-5nqsA: 2.7 5vkqB-5nqsA: 2.7	5vkqA-5nqsA: 8.00 5vkqB-5nqsA: 8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1807_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5nqs	PROTEIN TOPLESS (Arabidopsis thaliana)	4 / 6	ILE A 72 ILE A 96 LEU A 101 PHE A 104	None	0.93A	5vkqA-5nqsA: 2.7 5vkqD-5nqsA: 2.7	5vkqA-5nqsA: 8.00 5vkqD-5nqsA: 8.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FBM_B_RTLB951_0","PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN)","5nqs","PROTEIN TOPLESS","Arabidopsis thaliana",4,"THR A 165;LEU A 166;LEU A 174;GLN A 177","None","1.07A","1fbmA-5nqsA:undetectable","1fbmA-5nqsA:14.29"],["3UFG_B_LEUB289_0","GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT","5nqs","PROTEIN TOPLESS","Arabidopsis thaliana",3,"PHE A  34;SER A   3;SER A   5","None","0.88A","3ufgB-5nqsA:undetectable","3ufgB-5nqsA:24.61"],["5VKQ_A_PCFA1801_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5nqs","PROTEIN TOPLESS","Arabidopsis thaliana",4,"ILE A  72;ILE A  96;LEU A 101;PHE A 104","None","0.95A","5vkqA-5nqsA:2.7;5vkqB-5nqsA:2.7","5vkqA-5nqsA:8.00;5vkqB-5nqsA:8.00"],["5VKQ_D_PCFD1807_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5nqs","PROTEIN TOPLESS","Arabidopsis thaliana",4,"ILE A  72;ILE A  96;LEU A 101;PHE A 104","None","0.93A","5vkqA-5nqsA:2.7;5vkqD-5nqsA:2.7","5vkqA-5nqsA:8.00;5vkqD-5nqsA:8.00"]]