SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 4 HIS A 222
LEU A 147
LEU A 143
LEU A 117
 None
 1.11A 1a4lD-5nr1A:
undetectable		 1a4lD-5nr1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 GLU A  81
THR A  80
HIS A  76
LEU A  56
 None
 1.36A 1d4fC-5nr1A:
undetectable		 1d4fC-5nr1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		3 / 3 ALA A 174
HIS A 175
VAL A 178
 None
 0.19A 1lqtB-5nr1A:
undetectable		 1lqtB-5nr1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		3 / 3 ALA A 174
HIS A 175
VAL A 178
 None
 0.23A 1lquB-5nr1A:
undetectable		 1lquB-5nr1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		3 / 3 PHE A  10
TRP A  38
GLU A  39
 None
 0.60A 1mogA-5nr1A:
undetectable		 1mogA-5nr1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 7 LEU A 217
PHE A 182
LEU A 125
SER A  16
 None
 0.86A 1wrlE-5nr1A:
undetectable
1wrlF-5nr1A:
undetectable		 1wrlE-5nr1A:
15.79
1wrlF-5nr1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 11 PHE A 104
PHE A 108
ILE A 150
GLY A 148
LEU A 143
 None
 1.08A 1z11B-5nr1A:
undetectable		 1z11B-5nr1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 9 LEU A 176
GLY A 139
PRO A 186
VAL A 185
ILE A 179
 None
 1.06A 2avoA-5nr1A:
undetectable		 2avoA-5nr1A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 GLY A 216
TRP A 214
ARG A 124
LEU A 217
 None
 1.42A 2j2pD-5nr1A:
undetectable
2j2pF-5nr1A:
undetectable		 2j2pD-5nr1A:
19.15
2j2pF-5nr1A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 LEU A 100
ASP A 169
ALA A 168
ILE A 150
 None
 0.96A 2qhfA-5nr1A:
undetectable		 2qhfA-5nr1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 9 LEU A 176
GLY A 139
PRO A 186
VAL A 185
ILE A 179
 None
 0.99A 3d1yB-5nr1A:
undetectable		 3d1yB-5nr1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 TYR A 149
ALA A 168
ALA A 193
TYR A 197
 None
 1.05A 3d91A-5nr1A:
undetectable		 3d91A-5nr1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 8 LEU A 125
PRO A  41
PRO A  53
MET A  52
 None
 1.11A 3hcrA-5nr1A:
undetectable		 3hcrA-5nr1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 6 LEU A  28
LEU A  23
LEU A 167
LEU A  74
 None
 1.11A 3q1eA-5nr1A:
undetectable
3q1eC-5nr1A:
undetectable		 3q1eA-5nr1A:
18.42
3q1eC-5nr1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 9 HIS A   9
LEU A   7
PRO A  54
LEU A  56
LEU A  74
 None
 1.14A 3q1eB-5nr1A:
undetectable
3q1eD-5nr1A:
undetectable		 3q1eB-5nr1A:
18.42
3q1eD-5nr1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 9 HIS A   9
LEU A   7
PRO A  54
LEU A  56
THR A  70
 None
 0.90A 3q1eB-5nr1A:
undetectable
3q1eD-5nr1A:
undetectable		 3q1eB-5nr1A:
18.42
3q1eD-5nr1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 11 PHE A 104
PHE A 108
ILE A 150
GLY A 148
LEU A 143
 None
 1.04A 3t3rA-5nr1A:
undetectable		 3t3rA-5nr1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 LEU A  28
PRO A  29
LEU A  23
ILE A  77
 None
 1.04A 4klrA-5nr1A:
undetectable		 4klrA-5nr1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 6 HIS A   8
LEU A   7
CYH A  68
HIS A   9
 None
 1.27A 5hrqD-5nr1A:
undetectable
5hrqG-5nr1A:
undetectable
5hrqH-5nr1A:
undetectable		 5hrqD-5nr1A:
11.45
5hrqG-5nr1A:
6.31
5hrqH-5nr1A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 9 LEU A 176
GLY A 139
PRO A 186
VAL A 185
ILE A 179
 None
 1.15A 5kr2D-5nr1A:
undetectable		 5kr2D-5nr1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		5 / 12 VAL A   3
LYS A  26
LEU A  28
LEU A  56
ILE A  67
 None
 1.13A 5xprA-5nr1A:
2.1		 5xprA-5nr1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 5 VAL A 178
PRO A  54
MET A  52
VAL A  35
 None
 1.19A 6ekzA-5nr1A:
undetectable		 6ekzA-5nr1A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5nr1 FTSZ-BINDING PROTEIN
FZLA
(Caulobacter
vibrioides) 		4 / 6 THR A   6
LEU A   7
THR A  59
LEU A  28
 None
 1.20A 6mvxA-5nr1A:
undetectable
6mvxB-5nr1A:
2.4
6mvxC-5nr1A:
2.5		 6mvxA-5nr1A:
18.33
6mvxB-5nr1A:
18.33
6mvxC-5nr1A:
18.33