SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.96A 1drbB-5nr4A:
undetectable		 1drbB-5nr4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A  43
LEU A  82
TYR A  89
GLY A  50
GLY A  47
 None
 1.30A 1httB-5nr4A:
undetectable		 1httB-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A 191
THR A 155
LEU A 176
ALA A 134
LEU A 173
 None
 1.37A 1jipA-5nr4A:
undetectable		 1jipA-5nr4A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.97A 1ra2A-5nr4A:
undetectable		 1ra2A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		6 / 12 ILE A 189
ALA A 187
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.46A 1ra8A-5nr4A:
undetectable		 1ra8A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		6 / 12 ILE A 189
ALA A 187
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.47A 1rb2A-5nr4A:
undetectable		 1rb2A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.96A 1rd7A-5nr4A:
undetectable		 1rd7A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.02A 1rx2A-5nr4A:
undetectable		 1rx2A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.98A 4ej1A-5nr4A:
undetectable		 4ej1A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.04A 4kjjA-5nr4A:
undetectable		 4kjjA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.02A 4kjkA-5nr4A:
undetectable		 4kjkA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.00A 4kjlA-5nr4A:
undetectable		 4kjlA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.02A 4p3qA-5nr4A:
undetectable		 4p3qA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 1.03A 4p3rA-5nr4A:
undetectable		 4p3rA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU A  97
MET A 120
TYR A  89
 None
 0.88A 4p6xG-5nr4A:
undetectable		 4p6xG-5nr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU A 115
MET A 120
TYR A  89
 None
 0.85A 4p6xG-5nr4A:
undetectable		 4p6xG-5nr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		4 / 4 LEU A 190
VAL A 193
GLU A 194
ARG A 197
 None
 1.07A 4ww7A-5nr4A:
undetectable		 4ww7A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.89A 4x5iA-5nr4A:
undetectable		 4x5iA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  71
ASP A  80
VAL A  79
ALA A 112
LEU A 115
 None
 0.95A 5kocA-5nr4A:
undetectable		 5kocA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		4 / 6 LYS A 107
ARG A 100
GLU A 111
ALA A 112
 None
 1.23A 6an0A-5nr4A:
undetectable		 6an0A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5nr4 CLIP-ASSOCIATING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 189
PHE A 177
ILE A 170
LEU A 207
ILE A 192
 None
 0.99A 7dfrA-5nr4A:
undetectable		 7dfrA-5nr4A:
undetectable