SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 ARG A 126
ASP A 128
ASP A 136
ILE A 182
 EDO  A 408 (-3.7A)
None
None
None
 0.91A 2fxdB-5nriA:
undetectable		 2fxdB-5nriA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 PRO A 271
PRO A 117
GLU A 241
ARG A 248
 None
 1.09A 2v41E-5nriA:
undetectable
2v41F-5nriA:
undetectable		 2v41E-5nriA:
undetectable
2v41F-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A  73
GLN A  80
ILE A  79
SER A  20
 None
 1.07A 2xytH-5nriA:
undetectable		 2xytH-5nriA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A  73
GLN A  80
ILE A  79
SER A  20
 None
 1.08A 2xytI-5nriA:
undetectable		 2xytI-5nriA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A  97
GLY A 101
PHE A 250
ASP A 251
SER A  93
 None
 1.07A 3dlcA-5nriA:
2.5		 3dlcA-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 GLY A  92
PHE A 273
PHE A 250
GLY A 254
 None
 0.91A 3ko0M-5nriA:
undetectable
3ko0P-5nriA:
undetectable		 3ko0M-5nriA:
18.81
3ko0P-5nriA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A 250
GLY A 254
GLY A  92
PHE A 273
 None
 0.85A 3ko0M-5nriA:
undetectable
3ko0P-5nriA:
undetectable		 3ko0M-5nriA:
18.81
3ko0P-5nriA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 5 GLY A 269
PRO A 271
ASN A 270
TYR A 272
 None
 1.22A 3u8qA-5nriA:
undetectable		 3u8qA-5nriA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A 130
VAL A 181
ILE A 137
ALA A 134
 None
 0.94A 4lv9B-5nriA:
undetectable		 4lv9B-5nriA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 197
ALA A 195
ALA A 291
LEU A 203
PHE A 250
 None
 1.44A 4zo1X-5nriA:
undetectable		 4zo1X-5nriA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 6 TYR A 215
ARG A 260
GLY A 281
SER A 286
LEU A 287
 None
DAL  A 402 (-4.1A)
DAL  A 402 (-4.3A)
DAL  A 402 (-3.6A)
DAL  A 402 (-3.8A)
 0.72A 5bphA-5nriA:
39.8		 5bphA-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A 215
LYS A 220
TYR A 221
ARG A 260
 None
AMP  A 401 ( 4.2A)
None
DAL  A 402 (-4.1A)
 0.96A 5bphB-5nriA:
39.9		 5bphB-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 4 TYR A 215
GLY A 281
SER A 286
LEU A 287
 None
DAL  A 402 (-4.3A)
DAL  A 402 (-3.6A)
DAL  A 402 (-3.8A)
 0.76A 5bphC-5nriA:
39.9		 5bphC-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		4 / 6 ALA A  13
SER A  26
ASP A  48
PRO A  49
 None
 1.19A 5c6pA-5nriA:
undetectable		 5c6pA-5nriA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 199
SER A   2
ILE A   4
ARG A   8
ARG A  64
 None
 1.00A 5hi6B-5nriA:
undetectable		 5hi6B-5nriA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 9 GLY A  41
ARG A  38
ALA A  44
LEU A  37
GLY A  36
 None
 1.45A 5l8rA-5nriA:
undetectable		 5l8rA-5nriA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A 173
HIS A 177
ARG A 126
 None
None
EDO  A 408 (-3.7A)
 0.76A 5uunA-5nriA:
undetectable		 5uunA-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 10 LEU A  37
LEU A  57
LEU A  69
ALA A  68
LEU A  16
 None
 1.17A 5y7pD-5nriA:
undetectable		 5y7pD-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5nri D-ALANINE--D-ALANINE
LIGASE
(Burkholderia
pseudomallei) 		5 / 10 LEU A  37
LEU A  57
LEU A  69
ALA A  68
LEU A  16
 None
 1.17A 5y7pH-5nriA:
undetectable		 5y7pH-5nriA:
undetectable