SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		4 / 6 PHE A  95
SER B  16
THR A  35
PHE A 122
 None
 1.11A 1icuA-5nrmA:
undetectable
1icuB-5nrmA:
undetectable		 1icuA-5nrmA:
18.05
1icuB-5nrmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		4 / 5 PHE A  95
SER B  16
THR A  35
PHE A 122
 None
 1.22A 1icuC-5nrmA:
undetectable
1icuD-5nrmA:
undetectable		 1icuC-5nrmA:
18.05
1icuD-5nrmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		4 / 5 PHE A  95
SER B  16
THR A  35
PHE A 122
 None
 1.08A 1icvA-5nrmA:
undetectable
1icvB-5nrmA:
undetectable		 1icvA-5nrmA:
18.05
1icvB-5nrmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nrm ENDOGLUCANASE
DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
(Acetivibrio
cellulolyticus;
Acetivibrio
cellulolyticus) 		4 / 6 SER B  16
THR A  35
PHE A 122
PHE A  95
 None
 1.15A 1kqbA-5nrmB:
undetectable
1kqbB-5nrmB:
undetectable		 1kqbA-5nrmB:
undetectable
1kqbB-5nrmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		4 / 5 PHE B  55
LEU B  27
PHE B  19
SER A  34
 None
 1.37A 1wrkB-5nrmB:
undetectable		 1wrkB-5nrmB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5nrm ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		5 / 12 PHE A  38
LYS A  74
LEU A  98
ILE A   8
GLY A  55
 None
 1.03A 2lbdA-5nrmA:
undetectable		 2lbdA-5nrmA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5nrm ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		4 / 5 PHE A  38
PHE A 122
PHE A   4
VAL A  23
 None
 1.21A 2lh6A-5nrmA:
undetectable		 2lh6A-5nrmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		5 / 10 PHE A  38
ASP A  37
ASN B  15
VAL A  77
PHE A  95
 None
None
CA  B 101 ( 4.4A)
None
None
 1.41A 3ay0A-5nrmA:
2.1		 3ay0A-5nrmA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5nrm ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		3 / 3 SER A  85
ASP A  81
ASN A  64
 None
 0.98A 3lslA-5nrmA:
undetectable
3lslD-5nrmA:
undetectable		 3lslA-5nrmA:
undetectable
3lslD-5nrmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
(Acetivibrio
cellulolyticus) 		5 / 12 GLY B  10
ILE B  14
ASP B  37
ALA B  41
LEU B  44
 None
 0.81A 3uj7B-5nrmB:
undetectable		 3uj7B-5nrmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
ENDOGLUCANASE
(Acetivibrio
cellulolyticus) 		5 / 9 ALA A 132
PHE A   4
ILE A  57
VAL A  58
SER B  16
 None
 0.89A 4r20B-5nrmA:
undetectable		 4r20B-5nrmA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT
(Acetivibrio
cellulolyticus) 		3 / 3 LYS B   4
ASP B  37
ILE B  57
 None
 0.63A 5kc4E-5nrmB:
undetectable		 5kc4E-5nrmB:
18.12