SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ns3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDV_B_AICB376_1 (BETA-PEPTIDYL AMINOPEPTIDASE)	5ns3	50S RIBOSOMAL PROTEIN L5 (Thermus thermophilus)	5 / 11	LEU A 111 LEU A 107 GLY A 177 LEU A 120 LEU A 173	None	1.33A	3ndvA-5ns3A: undetectable 3ndvB-5ns3A: undetectable	3ndvA-5ns3A: 13.15 3ndvB-5ns3A: 13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQF_B_QPSB951_1 (ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC)	5ns3	50S RIBOSOMAL PROTEIN L5 (Thermus thermophilus)	4 / 8	ARG A 21 GLU A 18 GLU A 14 LYS A 10	None	1.17A	4bqfB-5ns3A: undetectable	4bqfB-5ns3A: 7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE0_A_VORA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5ns3	50S RIBOSOMAL PROTEIN L5 (Thermus thermophilus)	5 / 9	PHE A 125 GLY A 129 THR A 161 LEU A 172 LEU A 19	None	1.43A	4ze0A-5ns3A: undetectable	4ze0A-5ns3A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXD_A_ZITA501_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E MPHH)	5ns3	50S RIBOSOMAL PROTEIN L5 (Thermus thermophilus)	4 / 7	PHE A 23 ALA A 163 GLY A 129 TYR A 131	None	0.94A	5uxdA-5ns3A: undetectable	5uxdA-5ns3A: 13.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3NDV_B_AICB376_1","BETA-PEPTIDYL AMINOPEPTIDASE;BETA-PEPTIDYL AMINOPEPTIDASE","5ns3","50S RIBOSOMAL PROTEIN L5","Thermus thermophilus",5,"LEU A 111;LEU A 107;GLY A 177;LEU A 120;LEU A 173","None","1.33A","3ndvA-5ns3A:undetectable;3ndvB-5ns3A:undetectable","3ndvA-5ns3A:13.15;3ndvB-5ns3A:13.15"],["4BQF_B_QPSB951_1","ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC","5ns3","50S RIBOSOMAL PROTEIN L5","Thermus thermophilus",4,"ARG A  21;GLU A  18;GLU A  14;LYS A  10","None","1.17A","4bqfB-5ns3A:undetectable","4bqfB-5ns3A:7.21"],["4ZE0_A_VORA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5ns3","50S RIBOSOMAL PROTEIN L5","Thermus thermophilus",5,"PHE A 125;GLY A 129;THR A 161;LEU A 172;LEU A  19","None","1.43A","4ze0A-5ns3A:undetectable","4ze0A-5ns3A:10.79"],["5UXD_A_ZITA501_1","MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH","5ns3","50S RIBOSOMAL PROTEIN L5","Thermus thermophilus",4,"PHE A  23;ALA A 163;GLY A 129;TYR A 131","None","0.94A","5uxdA-5ns3A:undetectable","5uxdA-5ns3A:13.96"]]