SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ILE A 256
GLY A 255
CYH A 340
LEU A 378
TYR A 351
 None
 1.45A 1dgmA-5nsqA:
undetectable		 1dgmA-5nsqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU A 272
PHE A 238
GLY A 231
LEU A 208
LEU A 324
 None
 0.95A 1nr6A-5nsqA:
undetectable		 1nr6A-5nsqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 CYH A 321
SER A 205
PHE A 320
LEU A 341
 None
 1.04A 1qcaA-5nsqA:
undetectable		 1qcaA-5nsqA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ALA A 345
ASN A 344
ILE A 291
ASP A 294
 None
None
None
MN  A 602 (-2.3A)
 1.09A 1yc2D-5nsqA:
undetectable		 1yc2D-5nsqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 315
GLY A 288
LEU A 339
VAL A 213
PRO A 511
 None
 1.01A 1zq9B-5nsqA:
undetectable		 1zq9B-5nsqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 LEU A 269
VAL A 270
THR A 271
VAL A 319
 None
 0.95A 2qblA-5nsqA:
undetectable		 2qblA-5nsqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 LEU A 324
ALA A 235
GLY A 231
PHE A 320
 None
 0.93A 2wq5A-5nsqA:
undetectable		 2wq5A-5nsqA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 405
GLY A 416
GLY A 476
HIS A 493
LEU A 417
 BB2  A 603 (-4.2A)
None
None
None
None
 0.99A 2x1lB-5nsqA:
2.3		 2x1lB-5nsqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  64
ASP A 142
VAL A 141
SER A 182
TYR A  34
 None
 1.45A 2y00A-5nsqA:
undetectable		 2y00A-5nsqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  64
ASP A 142
VAL A 141
SER A 182
TYR A  34
 None
 1.43A 2y00B-5nsqA:
undetectable		 2y00B-5nsqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  64
ASP A 142
VAL A 141
SER A 182
TYR A  34
 None
 1.43A 2y01B-5nsqA:
undetectable		 2y01B-5nsqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 256
GLY A 255
TYR A 253
GLY A 379
LEU A 378
 None
 1.20A 2y7kD-5nsqA:
undetectable		 2y7kD-5nsqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 VAL A 122
LEU A 126
ILE A 153
SER A 147
THR A  52
 None
 1.13A 3bjwB-5nsqA:
undetectable		 3bjwB-5nsqA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 154
ALA A 118
GLY A 432
GLU A 516
THR A 206
 None
 1.12A 3c6gB-5nsqA:
undetectable		 3c6gB-5nsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 VAL A 270
LEU A 212
ILE A 228
ALA A 229
ALA A 317
 None
 0.99A 3mdvA-5nsqA:
undetectable		 3mdvA-5nsqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 PHE A  28
PHE A 188
ALA A 155
THR A 206
 None
 1.13A 3t3sB-5nsqA:
undetectable		 3t3sB-5nsqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 THR A 507
GLU A 437
VAL A 123
THR A 124
PHE A  28
 None
 1.35A 3tbgC-5nsqA:
undetectable		 3tbgC-5nsqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 TYR A 351
GLY A 260
ILE A 256
GLY A 255
ILE A 376
 None
 1.05A 4eatB-5nsqA:
3.6		 4eatB-5nsqA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 LEU A 521
ALA A 427
ALA A 426
VAL A 419
VAL A 494
 None
 1.20A 4h1nA-5nsqA:
undetectable		 4h1nA-5nsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 514
VAL A 494
GLY A 411
PHE A 509
THR A 410
 None
 0.96A 4mubA-5nsqA:
undetectable		 4mubA-5nsqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 LEU A 339
LEU A 212
MET A 399
VAL A 500
 None
 1.12A 4okbA-5nsqA:
undetectable		 4okbA-5nsqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 PHE A 518
PRO A 332
VAL A 333
ALA A 326
 None
 1.21A 4w5oA-5nsqA:
2.6		 4w5oA-5nsqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 PHE A 518
PRO A 332
VAL A 333
ALA A 326
 None
 1.21A 4z4cA-5nsqA:
3.7		 4z4cA-5nsqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 PHE A 518
PRO A 332
VAL A 333
ALA A 326
 None
 1.24A 4z4dA-5nsqA:
undetectable		 4z4dA-5nsqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A 378
LEU A 496
GLY A 315
ALA A 316
 None
 0.56A 5f1aA-5nsqA:
undetectable		 5f1aA-5nsqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 378
LEU A 496
GLY A 315
ALA A 316
LEU A 339
 None
 1.22A 5iktB-5nsqA:
undetectable		 5iktB-5nsqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 VAL A 270
LEU A 378
LEU A 496
GLY A 315
ALA A 316
 None
 1.29A 5iktB-5nsqA:
undetectable		 5iktB-5nsqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 GLY A 314
ALA A 497
MET A 309
THR A 403
 None
 1.50A 5n0sB-5nsqA:
undetectable		 5n0sB-5nsqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A 453
VAL A 442
HIS A 493
ILE A 479
 None
 0.71A 5vkqB-5nsqA:
undetectable
5vkqC-5nsqA:
undetectable		 5vkqB-5nsqA:
15.17
5vkqC-5nsqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 VAL A 187
LEU A  64
VAL A  71
LEU A  56
 None
 0.89A 6bqgA-5nsqA:
1.2		 6bqgA-5nsqA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  64
ARG A  57
VAL A  61
PHE A  66
GLY A 105
 None
 1.34A 6brdA-5nsqA:
undetectable		 6brdA-5nsqA:
10.26